Wheels make players discard or otherwise replace much of their hands and draw a new batch of cards. Wheel decks exploit those mass hand changes through discard payoffs, draw triggers, graveyard strategies, or simply refilling an empty hand.
Nekusar, the Mindrazer damages opponents for drawing cards, while Waste Not rewards the cards they discard. Narset, Parter of Veils can make symmetrical wheel effects decidedly less symmetrical.