Urborg Syphon-Mage

{2}{B}, {T}, Discard a card: Each other player loses 2 life. You gain life equal to the life lost this way.

Orzhov Signet

Warlock Class

(Gain the next level as a sorcery to add its ability.)
At the beginning of your end step, if a creature died this turn, each opponent loses 1 life.
{1}{B}: Level 2
When this Class becomes level 2, look at the top three cards of your library. Put one of them into your hand and the rest into your graveyard.
{6}{B}: Level 3
At the beginning of your end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Cleansing

For each land, destroy that land unless any player pays 1 life.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Ankh of Mishra

Whenever a land enters, this artifact deals 2 damage to that land's controller.

Night's Whisper

Windborn Muse

Flying
Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Underworld Dreams

Whenever an opponent draws a card, this enchantment deals 1 damage to that player.

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Orzhov Locket

{T}: Add {W} or {B}.
{W/B}{W/B}{W/B}{W/B}, {T}, Sacrifice this artifact: Draw two cards.

Plains

Cliffhaven Vampire

Flying
Whenever you gain life, each opponent loses 1 life.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on this creature and you gain 1 life.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Divinity of Pride

Flying, lifelink
This creature gets +4/+4 as long as you have 25 or more life.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Court of Ambition

When this enchantment enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Fate Unraveler

Whenever an opponent draws a card, this creature deals 1 damage to that player.

Ghostly Prison

Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Temple of Silence

This land enters tapped.
When this land enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{T}: Add {W} or {B}.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Essence Pulse

You gain 2 life. Each creature gets -X/-X until end of turn, where X is the amount of life you gained this turn.

Koskun Falls

At the beginning of your upkeep, sacrifice this enchantment unless you tap an untapped creature you control.
Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Unmake

Shattered Angel

Flying
Whenever a land an opponent controls enters, you may gain 3 life.

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Utter End

Blood Clock

At the beginning of each player's upkeep, that player returns a permanent they control to its owner's hand unless they pay 2 life.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Leechridden Swamp

({T}: Add {B}.)
This land enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Pontiff of Blight

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Other creatures you control have extort. (If a creature has multiple instances of extort, each triggers separately.)

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Greed

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Fracture

Destroy target artifact, enchantment, or planeswalker.

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

High Priest of Penance

Whenever this creature is dealt damage, you may destroy target nonland permanent.

Agent of Masks

Palace Siege

As this enchantment enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Scholar of Athreos

{2}{B}: Each opponent loses 1 life. You gain life equal to the life lost this way.

Orzhov Guildmage

{2}{W}: Target player gains 1 life.
{2}{B}: Each player loses 1 life.

Marauding Blight-Priest

Righteous Cause

Whenever a creature attacks, you gain 1 life.

Swamp

Temporal Extortion

When you cast this spell, any player may pay half their life, rounded up. If a player does, counter Temporal Extortion.
Take an extra turn after this one.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. This artifact deals 1 damage to you.

Chancellor of the Annex

You may reveal this card from your opening hand. If you do, when each opponent casts their first spell of the game, counter that spell unless that player pays {1}.
Flying
Whenever an opponent casts a spell, counter it unless that player pays {1}.

Orzhov Basilica

This land enters tapped.
When this land enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Containment Priest

Flash
If a nontoken creature would enter and it wasn't cast, exile it instead.

Hissing Miasma

Whenever a creature attacks you, its controller loses 1 life.

Souls of the Faultless

Defender (This creature can't attack.)
Whenever this creature is dealt combat damage, you gain that much life and attacking player loses that much life.

Dingus Staff

Whenever a creature dies, this artifact deals 2 damage to that creature's controller.

Killing Wave

For each creature, its controller sacrifices it unless they pay X life.

Vindicate

Infernal Grasp

Destroy target creature. You lose 2 life.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Tithe Drinker

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.