Read the Bones

Scry 2, then draw two cards. You lose 2 life.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Emergence Zone

{T}: Add {C}.
{1}, {T}, Sacrifice Emergence Zone: You may cast spells this turn as though they had flash.

Sejiri Glacier

Sejiri Glacier enters the battlefield tapped.
{T}: Add {W}.

Sejiri Shelter

Target creature you control gains protection from the color of your choice until end of turn.

Sejiri Shelter // Sejiri Glacier

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Dauthi Voidwalker

Shadow (This creature can block or be blocked by only creatures with shadow.)
If a card would be put into an opponent's graveyard from anywhere, instead exile it with a void counter on it.
{T}, Sacrifice Dauthi Voidwalker: Choose an exiled card an opponent owns with a void counter on it. You may play it this turn without paying its mana cost.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Vile Entomber

Deathtouch
When Vile Entomber enters the battlefield, search your library for a card, put that card into your graveyard, then shuffle.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Swamp

Skeletal Scrying

As an additional cost to cast this spell, exile X cards from your graveyard.
You draw X cards and you lose X life.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Children of Korlis

Sacrifice Children of Korlis: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Shattered Sanctum

Shattered Sanctum enters the battlefield tapped unless you control two or more other lands.
{T}: Add {W} or {B}.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Ambition's Cost

You draw three cards and you lose 3 life.

Verdant Catacombs

{T}, Pay 1 life, Sacrifice Verdant Catacombs: Search your library for a Swamp or Forest card, put it onto the battlefield, then shuffle.

Secret Rendezvous

You and target opponent each draw three cards.

Glacial Chasm

Cumulative upkeep—Pay 2 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
When Glacial Chasm enters the battlefield, sacrifice a land.
Creatures you control can't attack.
Prevent all damage that would be dealt to you.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Mangara, the Diplomat

Lifelink
Whenever an opponent attacks with creatures, if two or more of those creatures are attacking you and/or planeswalkers you control, draw a card.
Whenever an opponent casts their second spell each turn, draw a card.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Faith's Shield

Target permanent you control gains protection from the color of your choice until end of turn.
Fateful hour — If you have 5 or less life, instead you and each permanent you control gain protection from the color of your choice until end of turn.

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters the battlefield tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Reprieve

Return target spell to its owner's hand.
Draw a card.

Grand Abolisher

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice Silent Clearing: Draw a card.

Despark

Exile target permanent with mana value 4 or greater.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Increasing Ambition

Search your library for a card and put that card into your hand. If this spell was cast from a graveyard, instead search your library for two cards and put those cards into your hand. Then shuffle.
Flashback {7}{B} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Isolated Chapel

Isolated Chapel enters the battlefield tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Jet Medallion

Black spells you cast cost {1} less to cast.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Thought Vessel

Vault of Champions

Vault of Champions enters the battlefield tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Evolving Wilds

{T}, Sacrifice Evolving Wilds: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Plunge into Darkness

Choose one —
• Sacrifice any number of creatures. You gain 3 life for each sacrificed creature.
• Pay X life, then look at the top X cards of your library. Put one of those cards into your hand and exile the rest.
Entwine {B} (Choose both if you pay the entwine cost.)

Orzhov Signet

Duress

Target opponent reveals their hand. You choose a noncreature, nonland card from it. That player discards that card.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia, Dark Angel to its owner's hand.

Mutavault

{T}: Add {C}.
{1}: Mutavault becomes a 2/2 creature with all creature types until end of turn. It's still a land.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Bojuka Bog

Bojuka Bog enters the battlefield tapped.
When Bojuka Bog enters the battlefield, exile target player's graveyard.
{T}: Add {B}.

Immolating Glare

Black Market Connections

At the beginning of your precombat main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Sign in Blood

Target player draws two cards and loses 2 life.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Pearl Medallion

White spells you cast cost {1} less to cast.

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Marsh Flats

{T}, Pay 1 life, Sacrifice Marsh Flats: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Sol Ring

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Thran Dynamo

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Scheming Symmetry

Choose two target players. Each of them searches their library for a card, then shuffles and puts that card on top.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Fetid Heath

{T}: Add {C}.
{W/B}, {T}: Add {W}{W}, {W}{B}, or {B}{B}.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.