Have

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Forbidden Crypt

If you would draw a card, return a card from your graveyard to your hand instead. If you can't, you lose the game.
If a card would be put into your graveyard from anywhere, exile that card instead.

Phyrexian Tyranny

Whenever a player draws a card, that player loses 2 life unless they pay {2}.

Phyrexian Rager

When Phyrexian Rager enters, you draw a card and you lose 1 life.

Demonic Pact

At the beginning of your upkeep, choose one that hasn't been chosen —
• This enchantment deals 4 damage to any target and you gain 4 life.
• Target opponent discards two cards.
• Draw two cards.
• You lose the game.

Greed

Zhentarim Bandit

Whenever Zhentarim Bandit attacks, you may pay 1 life. If you do, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Wretched Anurid

Whenever another creature enters, you lose 1 life.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Painful Truths

Converge — You draw X cards and you lose X life, where X is the number of colors of mana spent to cast this spell.

Plunge into Darkness

Choose one —
• Sacrifice any number of creatures. You gain 3 life for each creature sacrificed this way.
• Pay any amount of life, then look at that many cards from the top of your library. Put one of those cards into your hand and exile the rest.
Entwine {B} (Choose both if you pay the entwine cost.)

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Morinfen

Flying
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Demonic Lore

When Demonic Lore enters, draw three cards.
At the beginning of your end step, you lose 2 life for each card in your hand.

Nothic

Weird Insight — When Nothic dies, roll a d20.
1—9 | You draw a card and you lose 1 life.
10—19 | You draw two cards and you lose 2 life.
20 | You draw seven cards and you lose 7 life.

Shivan Reef

{T}: Add {C}.
{T}: Add {U} or {R}. Shivan Reef deals 1 damage to you.

Crypt Lurker

When Crypt Lurker enters, you may sacrifice a creature or discard a creature card. If you do, draw a card.

Jon Irenicus, Shattered One

At the beginning of your end step, target opponent gains control of up to one target creature you control. Put two +1/+1 counters on it and tap it. It's goaded for the rest of the game and it gains "This creature can't be sacrificed." (It attacks each combat if able and attacks a player other than you if able.)
Whenever a creature you own but don't control attacks, you draw a card.

Counterspell

Strands of Undeath

Enchant creature
When Strands of Undeath enters, target player discards two cards.
{B}: Regenerate enchanted creature.

Night's Whisper

Feed the Infection

You draw three cards and you lose 3 life.
Corrupted — Each opponent who has three or more poison counters loses 3 life.

Deep Analysis

Target player draws two cards.
Flashback—{1}{U}, Pay 3 life. (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Field Research

Kicker {2}{U} (You may pay an additional {2}{U} as you cast this spell.)
Draw two cards. If this spell was kicked, draw three cards instead.

Hoard Robber

Whenever Hoard Robber deals combat damage to a player, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Alchemist's Gambit

Cleave {4}{U}{U}{R} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Take an extra turn after this one. During that turn, damage can't be prevented. [At the beginning of that turn's end step, you lose the game.]
Exile Alchemist's Gambit.

Sulfurous Springs

{T}: Add {C}.
{T}: Add {B} or {R}. Sulfurous Springs deals 1 damage to you.

Demonic Consultation

Choose a card name. Exile the top six cards of your library, then reveal cards from the top of your library until you reveal a card with the chosen name. Put that card into your hand and exile all other cards revealed this way.

Talisman of Creativity

{T}: Add {C}.
{T}: Add {U} or {R}. Talisman of Creativity deals 1 damage to you.

Doomed Dissenter

When Doomed Dissenter dies, create a 2/2 black Zombie creature token.

Underground River

{T}: Add {C}.
{T}: Add {U} or {B}. Underground River deals 1 damage to you.

Bitter Reunion

When Bitter Reunion enters, you may discard a card. If you do, draw two cards.
{1}, Sacrifice Bitter Reunion: Creatures you control gain haste until end of turn.

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Infernal Sovereign

Flying, trample
Skip your draw step.
Whenever you play a land or cast a spell, you draw a card and you lose 1 life.

Phyrexian Gargantua

When Phyrexian Gargantua enters, you draw two cards and you lose 2 life.

Phyrexian Vivisector

Whenever a creature you control dies, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Nefarious Lich

If damage would be dealt to you, exile that many cards from your graveyard instead. If you can't, you lose the game.
If you would gain life, draw that many cards instead.
When Nefarious Lich leaves the battlefield, you lose the game.

Shadow Prophecy

Domain — Look at the top X cards of your library, where X is the number of basic land types among lands you control. Put up to two of them into your hand and the rest into your graveyard. You lose 2 life.

Immortal Coil

{T}, Exile two cards from your graveyard: Draw a card.
If damage would be dealt to you, prevent that damage. Exile a card from your graveyard for each 1 damage prevented this way.
When there are no cards in your graveyard, you lose the game.

Obeka, Brute Chronologist

{T}: The player whose turn it is may end the turn. (Exile all spells and abilities from the stack. The player whose turn it is discards down to their maximum hand size. Damage wears off, and "this turn" and "until end of turn" effects end.)

Slaughter Pact

Destroy target nonblack creature.
At the beginning of your next upkeep, pay {2}{B}. If you don't, you lose the game.

Ambition's Cost

You draw three cards and you lose 3 life.

Spoils of the Vault

Choose a card name. Reveal cards from the top of your library until you reveal a card with that name, then put that card into your hand. Exile all other cards revealed this way, and you lose 1 life for each of the exiled cards.

Island

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Mental Journey

Draw three cards.
Basic landcycling {1}{U} ({1}{U}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Bone Shards

As an additional cost to cast this spell, sacrifice a creature or discard a card.
Destroy target creature or planeswalker.

Talisman of Indulgence

{T}: Add {C}.
{T}: Add {B} or {R}. Talisman of Indulgence deals 1 damage to you.

Nightscape Familiar

Blue spells and red spells you cast cost {1} less to cast.
{1}{B}: Regenerate Nightscape Familiar.

Goldnight Castigator

Flying, haste
If a source would deal damage to you, it deals double that damage to you instead.
If a source would deal damage to Goldnight Castigator, it deals double that damage to Goldnight Castigator instead.

Lithoform Blight

Enchant land
When Lithoform Blight enters, draw a card.
Enchanted land loses all land types and abilities and has "{T}: Add {C}" and "{T}, Pay 1 life: Add one mana of any color."

Swamp

Hired Hexblade

When Hired Hexblade enters, if mana from a Treasure was spent to cast it, you draw a card and you lose 1 life.

Grim Bounty

Destroy target creature or planeswalker. Create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Painful Lesson

Target player draws two cards and loses 2 life.

Talisman of Dominance

{T}: Add {C}.
{T}: Add {U} or {B}. Talisman of Dominance deals 1 damage to you.

Divining Witch

{1}{B}, {T}, Discard a card: Choose a card name. Exile the top six cards of your library, then reveal cards from the top of your library until you reveal a card with the chosen name. Put that card into your hand and exile all other cards revealed this way.

Flesh Reaver

Whenever Flesh Reaver deals damage to a creature or opponent, Flesh Reaver deals that much damage to you.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Withercrown

Enchant creature
Enchanted creature has base power 0 and has "At the beginning of your upkeep, you lose 1 life unless you sacrifice this creature."

Infernal Grasp

Destroy target creature. You lose 2 life.

Toxic Abomination

When Toxic Abomination enters, you lose 2 life.

Dark Ritual

Mountain

Midnight Oil

Midnight Oil enters with seven hour counters on it.
At the beginning of your draw step, draw an additional card and remove two hour counters from Midnight Oil.
Your maximum hand size is equal to the number of hour counters on Midnight Oil.
Whenever you discard a card, you lose 1 life.

Treacherous Blessing

When Treacherous Blessing enters, draw three cards.
Whenever you cast a spell, you lose 1 life.
When Treacherous Blessing becomes the target of a spell or ability, sacrifice it.

Infectious Inquiry

You draw two cards and you lose 2 life. Each opponent gets a poison counter.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Malakir Mire

Malakir Mire enters tapped.
{T}: Add {B}.

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Sudden Insight

Draw a card for each different mana value among nonland cards in your graveyard.

Rust Elemental

Flying
At the beginning of your upkeep, sacrifice an artifact other than Rust Elemental. If you can't, tap Rust Elemental and you lose 4 life.

Abyssal Persecutor

Flying, trample
You can't win the game and your opponents can't lose the game.

Blood Price

Look at the top four cards of your library. Put two of them into your hand and the rest on the bottom of your library in any order. You lose 2 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Skullport Merchant

When Skullport Merchant enters, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")
{1}{B}, Sacrifice another creature or a Treasure: Draw a card.