Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Court of Ambition

When Court of Ambition enters the battlefield, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Honden of Seeing Winds

At the beginning of your upkeep, draw a card for each Shrine you control.

Progenitor Mimic

You may have Progenitor Mimic enter the battlefield as a copy of any creature on the battlefield, except it has "At the beginning of your upkeep, if this creature isn't a token, create a token that's a copy of this creature."

Talisman of Resilience

{T}: Add {C}.
{T}: Add {B} or {G}. Talisman of Resilience deals 1 damage to you.

Opulent Palace

Opulent Palace enters the battlefield tapped.
{T}: Add {B}, {G}, or {U}.

Hooded Blightfang

Deathtouch
Whenever a creature you control with deathtouch attacks, each opponent loses 1 life and you gain 1 life.
Whenever a creature you control with deathtouch deals damage to a planeswalker, destroy that planeswalker.

Bastion of Remembrance

When Bastion of Remembrance enters the battlefield, create a 1/1 white Human Soldier creature token.
Whenever a creature you control dies, each opponent loses 1 life and you gain 1 life.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Simic Signet

Dogged Pursuit

At the beginning of your end step, each opponent loses 1 life and you gain 1 life.

Vraska's Contempt

Exile target creature or planeswalker. You gain 2 life.

Palace Siege

As Palace Siege enters the battlefield, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Nyx Lotus

Nyx Lotus enters the battlefield tapped.
{T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Jungle Hollow

Jungle Hollow enters the battlefield tapped.
When Jungle Hollow enters the battlefield, you gain 1 life.
{T}: Add {B} or {G}.

Rune of Mortality

Enchant permanent
When Rune of Mortality enters the battlefield, draw a card.
As long as enchanted permanent is a creature, it has deathtouch.
As long as enchanted permanent is an Equipment, it has "Equipped creature has deathtouch."

Golgari Guildgate

Golgari Guildgate enters the battlefield tapped.
{T}: Add {B} or {G}.

Nezumi Road Captain

Menace
Vehicles you control have menace. (They can't be blocked except by two or more creatures.)

Okiba Reckoner Raid

(As this Saga enters and after your draw step, add a lore counter.)
I, II — Each opponent loses 1 life and you gain 1 life.
III — Exile this Saga, then return it to the battlefield transformed under your control.

Okiba Reckoner Raid // Nezumi Road Captain

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Island

Bloodbond Vampire

Whenever you gain life, put a +1/+1 counter on Bloodbond Vampire.

Sanctum Seeker

Whenever a Vampire you control attacks, each opponent loses 1 life and you gain 1 life.

Swamp

Loyal Subordinate

Menace
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Gloomshrieker

Menace (This creature can't be blocked except by two or more creatures.)
When Gloomshrieker enters the battlefield, return target permanent card from your graveyard to your hand.
If Gloomshrieker would die, exile it instead.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Sol Ring

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Blood Researcher

Menace (This creature can't be blocked except by two or more creatures.)
Whenever you gain life, put a +1/+1 counter on Blood Researcher.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

The Eldest Reborn

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Each opponent sacrifices a creature or planeswalker.
II — Each opponent discards a card.
III — Put target creature or planeswalker card from a graveyard onto the battlefield under your control.

Manalith

Leeching Lurker

Lifelink
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Curse of Leeches

Enchant player
As this permanent transforms into Curse of Leeches, attach it to a player.
At the beginning of enchanted player's upkeep, they lose 1 life and you gain 1 life.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Curse of Leeches // Leeching Lurker

Dismal Backwater

Dismal Backwater enters the battlefield tapped.
When Dismal Backwater enters the battlefield, you gain 1 life.
{T}: Add {U} or {B}.

Falkenrath Noble

Flying
Whenever Falkenrath Noble or another creature dies, target player loses 1 life and you gain 1 life.

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Ophidian Eye

Flash (You may cast this spell any time you could cast an instant.)
Enchant creature
Whenever enchanted creature deals damage to an opponent, you may draw a card.

Spawn of Mayhem

Spectacle {1}{B}{B} (You may cast this spell for its spectacle cost rather than its mana cost if an opponent lost life this turn.)
Flying, trample
At the beginning of your upkeep, Spawn of Mayhem deals 1 damage to each player. Then if you have 10 or less life, put a +1/+1 counter on Spawn of Mayhem.

Double Major

Copy target creature spell you control, except it isn't legendary if the spell is legendary. (A copy of a creature spell becomes a token.)

Marauding Blight-Priest

Agent of Erebos

Constellation — Whenever Agent of Erebos or another enchantment enters the battlefield under your control, exile target player's graveyard.

Black Market

Whenever a creature dies, put a charge counter on Black Market.
At the beginning of your precombat main phase, add {B} for each charge counter on Black Market.

Golgari Signet

Spark Double

You may have Spark Double enter the battlefield as a copy of a creature or planeswalker you control, except it enters with an additional +1/+1 counter on it if it's a creature, it enters with an additional loyalty counter on it if it's a planeswalker, and it isn't legendary.

Sanctum of Calm Waters

At the beginning of your precombat main phase, you may draw X cards, where X is the number of Shrines you control. If you do, discard a card.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Mirror Image

You may have Mirror Image enter the battlefield as a copy of a creature you control.

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Zulaport Cutthroat

Whenever Zulaport Cutthroat or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Tatsunari, Toad Rider

Whenever you cast an enchantment spell, if you don't control a creature named Keimi, create Keimi, a legendary 3/3 black and green Frog creature token with "Whenever you cast an enchantment spell, each opponent loses 1 life and you gain 1 life."
{1}{G/U}: Tatsunari, Toad Rider and target Frog you control can't be blocked this turn except by creatures with flying or reach.

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Murder

Krydle of Baldur's Gate

Whenever Krydle of Baldur's Gate deals combat damage to a player, that player loses 1 life and mills a card, then you gain 1 life and scry 1.
Whenever you attack, you may pay {2}. If you do, target creature can't be blocked this turn.

Sanctum of Stone Fangs

At the beginning of your precombat main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Helm of the Host

At the beginning of combat on your turn, create a token that's a copy of equipped creature, except the token isn't legendary. That token gains haste.
Equip {5}

Grim Guardian

Constellation — Whenever Grim Guardian or another enchantment enters the battlefield under your control, each opponent loses 1 life.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Dimir Guildgate

Dimir Guildgate enters the battlefield tapped.
{T}: Add {U} or {B}.

Ill-Gotten Inheritance

At the beginning of your upkeep, Ill-Gotten Inheritance deals 1 damage to each opponent and you gain 1 life.
{5}{B}, Sacrifice Ill-Gotten Inheritance: It deals 4 damage to target opponent and you gain 4 life.

Protean Thaumaturge

Constellation — Whenever an enchantment enters the battlefield under your control, you may have Protean Thaumaturge become a copy of another target creature, except it has this ability.

Chromatic Lantern

Lands you control have "{T}: Add one mana of any color."
{T}: Add one mana of any color.

Blightcaster

Whenever you cast an enchantment spell, you may have target creature get -2/-2 until end of turn.

Mastermind's Acquisition

Choose one —
• Search your library for a card, put it into your hand, then shuffle.
• Put a card you own from outside the game into your hand.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters the battlefield, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Forsaken Wastes

Players can't gain life.
At the beginning of each player's upkeep, that player loses 1 life.
Whenever Forsaken Wastes becomes the target of a spell, that spell's controller loses 5 life.

Curiosity

Enchant creature
Whenever enchanted creature deals damage to an opponent, you may draw a card.

Ravenous Chupacabra

When Ravenous Chupacabra enters the battlefield, destroy target creature an opponent controls.

Yawgmoth's Edict

Whenever an opponent casts a white spell, that player loses 1 life and you gain 1 life.

Retreat to Hagra

Landfall — Whenever a land enters the battlefield under your control, choose one —
• Target creature gets +1/+0 and gains deathtouch until end of turn.
• Each opponent loses 1 life and you gain 1 life.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Frogify

Enchant creature
Enchanted creature loses all abilities and is a blue Frog creature with base power and toughness 1/1. (It loses all other card types and creature types.)

Ancestral Mask

Enchant creature
Enchanted creature gets +2/+2 for each other enchantment on the battlefield.