Relic Bane

Enchant artifact
Enchanted artifact has "At the beginning of your upkeep, you lose 2 life."

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Bloodsoaked Reveler

At the beginning of your end step, if you gained life this turn, create a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this token: Draw a card.")
{4}{B}: Each opponent loses 2 life and you gain 2 life.

Restless Bloodseeker

At the beginning of your end step, if you gained life this turn, create a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this token: Draw a card.")
Sacrifice two Blood tokens: Transform this creature. Activate only as a sorcery.

Restless Bloodseeker // Bloodsoaked Reveler

Bond of Agony

As an additional cost to cast this spell, pay X life.
Each other player loses X life.

Artifact Possession

Enchant artifact
Whenever enchanted artifact becomes tapped or a player activates an ability of enchanted artifact without {T} in its activation cost, this Aura deals 2 damage to that artifact's controller.

Noxious Field

Enchant land
Enchanted land has "{T}: This land deals 1 damage to each creature and each player."

Steam Vines

Enchant land
When enchanted land becomes tapped, destroy it and this Aura deals 1 damage to that land's controller. That player attaches this Aura to a land of their choice.

Pestilence

At the beginning of the end step, if no creatures are on the battlefield, sacrifice this enchantment.
{B}: This enchantment deals 1 damage to each creature and each player.

Contaminated Ground

Enchant land
Enchanted land is a Swamp.
Whenever enchanted land becomes tapped, its controller loses 2 life.

Vindictive Vampire

Whenever another creature you control dies, this creature deals 1 damage to each opponent and you gain 1 life.

Priest of Forgotten Gods

{T}, Sacrifice two other creatures: Any number of target players each lose 2 life and sacrifice a creature of their choice. You add {B}{B} and draw a card.

Relic Putrescence

Enchant artifact
Whenever enchanted artifact becomes tapped, its controller gets a poison counter.

Gray Merchant of Asphodel

When this creature enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Malakir Blood-Priest

When this creature enters, each opponent loses X life and you gain X life, where X is the number of creatures in your party. (Your party consists of up to one each of Cleric, Rogue, Warrior, and Wizard.)

Arrogant Outlaw

When this creature enters, if an opponent lost life this turn, each opponent loses 2 life and you gain 2 life.

Gremlin Infestation

Enchant artifact
At the beginning of your end step, this Aura deals 2 damage to enchanted artifact's controller.
When enchanted artifact is put into a graveyard, create a 2/2 red Gremlin creature token.

Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Glass-Cast Heart

Whenever one or more Vampires you control attack, create a Blood token. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this token: Draw a card.")
{B}, {T}, Pay 1 life: Create a 1/1 white and black Vampire creature token with lifelink.
{B}{B}, {T}, Sacrifice this artifact and thirteen Blood tokens: Each opponent loses 13 life and you gain 13 life.

Curse Artifact

Enchant artifact
At the beginning of the upkeep of enchanted artifact's controller, this Aura deals 2 damage to that player unless they sacrifice that artifact.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Anje, Maid of Dishonor

Whenever Anje and/or one or more other Vampires you control enter, create a Blood token. This ability triggers only once each turn. (It's an artifact with "{1}, {T}, Discard a card, Sacrifice this token: Draw a card.")
{2}, Sacrifice another creature or a Blood token: Each opponent loses 2 life and you gain 2 life.

Vermin Gorger

{T}, Sacrifice another creature: Each opponent loses 2 life and you gain 2 life.

Creeping Bloodsucker

At the beginning of your upkeep, this creature deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Baneful Omen

At the beginning of your end step, you may reveal the top card of your library. If you do, each opponent loses life equal to that card's mana value.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control of their choice, then sacrifices a third of the lands they control of their choice. Round up each time.

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Basilica Screecher

Flying
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Cursed Land

Enchant land
At the beginning of the upkeep of enchanted land's controller, this Aura deals 1 damage to that player.

Pestilence Demon

Flying
{B}: This creature deals 1 damage to each creature and each player.

Florian, Voldaren Scion

First strike
At the beginning of each of your postcombat main phases, look at the top X cards of your library, where X is the total amount of life your opponents lost this turn. Exile one of those cards and put the rest on the bottom of your library in a random order. You may play the exiled card this turn.

Blood Seeker

Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Orcish Mine

Enchant land
This Aura enters with three ore counters on it.
At the beginning of your upkeep and whenever enchanted land becomes tapped, remove an ore counter from this Aura.
When the last ore counter is removed from this Aura, destroy enchanted land and this Aura deals 2 damage to that land's controller.

Ill-Gotten Inheritance

At the beginning of your upkeep, this enchantment deals 1 damage to each opponent and you gain 1 life.
{5}{B}, Sacrifice this enchantment: It deals 4 damage to target opponent and you gain 4 life.

Blight

Enchant land
When enchanted land becomes tapped, destroy it.

Palace Siege

As this enchantment enters, choose Khans or Dragons.
• Khans — At the beginning of your upkeep, return target creature card from your graveyard to your hand.
• Dragons — At the beginning of your upkeep, each opponent loses 2 life and you gain 2 life.

Malakir Bloodwitch

Flying, protection from white
When this creature enters, each opponent loses life equal to the number of Vampires you control. You gain life equal to the life lost this way.

Evil Presence

Vampire Neonate

{2}, {T}: Each opponent loses 1 life and you gain 1 life.

Bellowing Mauler

At the beginning of your end step, each player loses 4 life unless they sacrifice a nontoken creature of their choice.

Pooling Venom

Enchant land
Whenever enchanted land becomes tapped, its controller loses 2 life.
{3}{B}: Destroy enchanted land.

Blood Tribute

Kicker—Tap an untapped Vampire you control. (You may tap a Vampire you control in addition to any other costs as you cast this spell.)
Target opponent loses half their life, rounded up. If this spell was kicked, you gain life equal to the life lost this way.

Clawing Torment

Enchant artifact or creature
As long as enchanted permanent is a creature, it gets -1/-1 and can't block.
Enchanted permanent has "At the beginning of your upkeep, you lose 1 life."