Licia, Sanguine Tribune

This spell costs {1} less to cast for each 1 life you gained this turn.
First strike, lifelink
Pay 5 life: Put three +1/+1 counters on Licia, Sanguine Tribune. Activate only during your turn and only once each turn.

Nomad Outpost

Nomad Outpost enters the battlefield tapped.
{T}: Add {R}, {W}, or {B}.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Tithe Drinker

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Tibalt, Rakish Instigator

Your opponents can't gain life.
−2: Create a 1/1 red Devil creature token with "When this creature dies, it deals 1 damage to any target."

Underworld Coinsmith

Constellation — Whenever Underworld Coinsmith or another enchantment enters the battlefield under your control, you gain 1 life.
{W}{B}, Pay 1 life: Each opponent loses 1 life.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Boros Garrison

Boros Garrison enters the battlefield tapped.
When Boros Garrison enters the battlefield, return a land you control to its owner's hand.
{T}: Add {R}{W}.

Plea for Guidance

Search your library for up to two enchantment cards, reveal them, put them into your hand, then shuffle.

Boseiju, Who Shelters All

Boseiju, Who Shelters All enters the battlefield tapped.
{T}, Pay 2 life: Add {C}. If that mana is spent on an instant or sorcery spell, that spell can't be countered.

Renegade Map

Renegade Map enters the battlefield tapped.
{T}, Sacrifice Renegade Map: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Greed

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Immolating Souleater

{R/P}: Immolating Souleater gets +1/+0 until end of turn. ({R/P} can be paid with either {R} or 2 life.)

Invincible Hymn

Count the number of cards in your library. Your life total becomes that number.

Darksteel Ingot

Indestructible (Effects that say "destroy" don't destroy this artifact.)
{T}: Add one mana of any color.

Mischievous Poltergeist

Flying
Pay 1 life: Regenerate Mischievous Poltergeist.

Kuro, Pitlord

At the beginning of your upkeep, sacrifice Kuro, Pitlord unless you pay {B}{B}{B}{B}.
Pay 1 life: Target creature gets -1/-1 until end of turn.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

Orzhov Basilica

Orzhov Basilica enters the battlefield tapped.
When Orzhov Basilica enters the battlefield, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Vandalblast

Destroy target artifact you don't control.
Overload {4}{R} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Exquisite Archangel

Flying
If you would lose the game, instead exile Exquisite Archangel and your life total becomes equal to your starting life total.

Moltensteel Dragon

({R/P} can be paid with either {R} or 2 life.)
Flying
{R/P}: Moltensteel Dragon gets +1/+0 until end of turn.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Sigarda's Splendor

As Sigarda's Splendor enters the battlefield, note your life total.
At the beginning of your upkeep, draw a card if your life total is greater than or equal to the last noted life total for Sigarda's Splendor. Then note your life total.
Whenever you cast a white spell, you gain 1 life.

Celestial Mantle

Enchant creature
Enchanted creature gets +3/+3.
Whenever enchanted creature deals combat damage to a player, double its controller's life total.

Ayli, Eternal Pilgrim

Deathtouch
{1}, Sacrifice another creature: You gain life equal to the sacrificed creature's toughness.
{1}{W}{B}, Sacrifice another creature: Exile target nonland permanent. Activate only if you have at least 10 life more than your starting life total.

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Rakdos Carnarium

Rakdos Carnarium enters the battlefield tapped.
When Rakdos Carnarium enters the battlefield, return a land you control to its owner's hand.
{T}: Add {B}{R}.

Scoured Barrens

Scoured Barrens enters the battlefield tapped.
When Scoured Barrens enters the battlefield, you gain 1 life.
{T}: Add {W} or {B}.

Bloodfell Caves

Bloodfell Caves enters the battlefield tapped.
When Bloodfell Caves enters the battlefield, you gain 1 life.
{T}: Add {B} or {R}.

Hex Parasite

{X}{B/P}: Remove up to X counters from target permanent. For each counter removed this way, Hex Parasite gets +1/+0 until end of turn. ({B/P} can be paid with either {B} or 2 life.)

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Tainted Sigil

{T}, Sacrifice Tainted Sigil: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Ethereal Champion

Pay 1 life: Prevent the next 1 damage that would be dealt to Ethereal Champion this turn.

Eternity Vessel

Eternity Vessel enters the battlefield with X charge counters on it, where X is your life total.
Landfall — Whenever a land enters the battlefield under your control, you may have your life total become the number of charge counters on Eternity Vessel.

Soul of New Phyrexia

Trample
{5}: Permanents you control gain indestructible until end of turn.
{5}, Exile Soul of New Phyrexia from your graveyard: Permanents you control gain indestructible until end of turn.

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Phyrexian Lens

{T}, Pay 1 life: Add one mana of any color.

Blinding Souleater

{W/P}, {T}: Tap target creature. ({W/P} can be paid with either {W} or 2 life.)

Swamp

Rakdos Signet

Orzhov Signet

Earthquake

Earthquake deals X damage to each creature without flying and each player.

Merciless Eviction

Choose one —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all planeswalkers.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Evolving Wilds

{T}, Sacrifice Evolving Wilds: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Utter End

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Plains

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Liesa, Forgotten Archangel

Flying, lifelink
Whenever another nontoken creature you control dies, return that card to its owner's hand at the beginning of the next end step.
If a creature an opponent controls would die, exile it instead.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Order of the Sacred Torch

{T}, Pay 1 life: Counter target black spell.

Wind-Scarred Crag

Wind-Scarred Crag enters the battlefield tapped.
When Wind-Scarred Crag enters the battlefield, you gain 1 life.
{T}: Add {R} or {W}.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Sacred Foundry

({T}: Add {R} or {W}.)
As Sacred Foundry enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Boros Signet

Resolute Archangel

Flying
When Resolute Archangel enters the battlefield, if your life total is less than your starting life total, it becomes equal to your starting life total.

Approach of the Second Sun

If this spell was cast from your hand and you've cast another spell named Approach of the Second Sun this game, you win the game. Otherwise, put Approach of the Second Sun into its owner's library seventh from the top and you gain 7 life.

Chalice of Death

Chalice of Life

{T}: You gain 1 life. Then if you have at least 10 life more than your starting life total, transform Chalice of Life.

Chalice of Life // Chalice of Death

Mountain

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter the battlefield tapped.

Arbiter of Knollridge

Vigilance
When Arbiter of Knollridge enters the battlefield, each player's life total becomes the highest life total among all players.