Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Mindslicer

When Mindslicer dies, each player discards their hand.

Virus Beetle

When Virus Beetle enters, each opponent discards a card.

The Raven Man

At the beginning of each end step, if a player discarded a card this turn, create a 1/1 black Bird creature token with flying and "This creature can't block."
{3}{B}, {T}: Each opponent discards a card. Activate only as a sorcery.

Oppression

Whenever a player casts a spell, that player discards a card.

Takenuma, Abandoned Mire

{T}: Add {B}.
Channel — {3}{B}, Discard Takenuma, Abandoned Mire: Mill three cards, then return a creature or planeswalker card from your graveyard to your hand. This ability costs {1} less to activate for each legendary creature you control.

Tourach, Dread Cantor

Kicker {B}{B} (You may pay an additional {B}{B} as you cast this spell.)
Protection from white
Whenever an opponent discards a card, put a +1/+1 counter on Tourach, Dread Cantor.
When Tourach enters, if it was kicked, target opponent discards two cards at random.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Waste Not

Whenever an opponent discards a creature card, create a 2/2 black Zombie creature token.
Whenever an opponent discards a land card, add {B}{B}.
Whenever an opponent discards a noncreature, nonland card, draw a card.

Rankle's Prank

Choose one or more —
• Each player discards two cards.
• Each player loses 4 life.
• Each player sacrifices two creatures of their choice.

Sol Ring

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Geier Reach Sanitarium

{T}: Add {C}.
{2}, {T}: Each player draws a card, then discards a card.

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Shrieking Affliction

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, they lose 3 life.

Hopeless Nightmare

When Hopeless Nightmare enters, each opponent discards a card and loses 2 life.
When Hopeless Nightmare is put into a graveyard from the battlefield, scry 2.
{2}{B}: Sacrifice Hopeless Nightmare.

Nezumi Informant

When Nezumi Informant enters, each opponent discards a card.

Davriel, Rogue Shadowmage

At the beginning of each opponent's upkeep, if that player has one or fewer cards in hand, Davriel, Rogue Shadowmage deals 2 damage to them.
−1: Target player discards a card.

Court of Ambition

When Court of Ambition enters, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Necrogoyf

Necrogoyf's power is equal to the number of creature cards in all graveyards.
At the beginning of each player's upkeep, that player discards a card.
Madness {1}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Wheel of Torture

At the beginning of each opponent's upkeep, Wheel of Torture deals X damage to that player, where X is 3 minus the number of cards in their hand.

Elderfang Disciple

When Elderfang Disciple enters, each opponent discards a card.

Raiders' Wake

Whenever an opponent discards a card, that player loses 2 life.
Raid — At the beginning of your end step, if you attacked this turn, target opponent discards a card.

Smokestack

At the beginning of your upkeep, you may put a soot counter on Smokestack.
At the beginning of each player's upkeep, that player sacrifices a permanent of their choice for each soot counter on Smokestack.

Tinybones, Trinket Thief

At the beginning of each end step, if an opponent discarded a card this turn, you draw a card and you lose 1 life.
{4}{B}{B}: Each opponent with no cards in hand loses 10 life.

Faith of the Devoted

Whenever you cycle or discard a card, you may pay {1}. If you do, each opponent loses 2 life and you gain 2 life.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Liliana of the Veil

+1: Each player discards a card.
−2: Target player sacrifices a creature.
−6: Separate all permanents target player controls into two piles. That player sacrifices all permanents in the pile of their choice.

Cunning Lethemancer

At the beginning of your upkeep, each player discards a card.

Archfiend of Ifnir

Flying
Whenever you cycle or discard another card, put a -1/-1 counter on each creature your opponents control.
Cycling {2} ({2}, Discard this card: Draw a card.)

Bone Miser

Whenever you discard a creature card, create a 2/2 black Zombie creature token.
Whenever you discard a land card, add {B}{B}.
Whenever you discard a noncreature, nonland card, draw a card.

Liliana's Caress

Whenever an opponent discards a card, that player loses 2 life.

Words of Waste

{1}: The next time you would draw a card this turn, each opponent discards a card instead.

Delirium Skeins

Asylum Visitor

At the beginning of each player's upkeep, if that player has no cards in hand, you draw a card and you lose 1 life.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Rotting Rats

When Rotting Rats enters, each player discards a card.
Unearth {1}{B} ({1}{B}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Plaguecrafter

When Plaguecrafter enters, each player sacrifices a creature or planeswalker of their choice. Each player who can't discards a card.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Nykthos, Shrine to Nyx

{T}: Add {C}.
{2}, {T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Chain of Smog

Target player discards two cards. That player may copy this spell and may choose a new target for that copy.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Dreamstealer

Menace
Whenever Dreamstealer deals combat damage to a player, that player discards that many cards.
Eternalize {4}{B}{B} ({4}{B}{B}, Exile this card from your graveyard: Create a token that's a copy of it, except it's a 4/4 black Zombie Human Wizard with no mana cost. Eternalize only as a sorcery.)

Nyx Lotus

Nyx Lotus enters tapped.
{T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Skullclamp

Equipped creature gets +1/-1.
Whenever equipped creature dies, draw two cards.
Equip {1}

Tergrid's Lantern

{T}: Target player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.
{3}{B}: Untap Tergrid's Lantern.

Tergrid, God of Fright

Menace
Whenever an opponent sacrifices a nontoken permanent or discards a permanent card, you may put that card from a graveyard onto the battlefield under your control.

Tergrid, God of Fright // Tergrid's Lantern

Elvish Doomsayer

When Elvish Doomsayer dies, each opponent discards a card.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Library of Leng

You have no maximum hand size.
If an effect causes you to discard a card, discard it, but you may put it on top of your library instead of into your graveyard.

Vicious Rumors

Vicious Rumors deals 1 damage to each opponent. Each opponent discards a card, then mills a card. You gain 1 life.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Quest for the Nihil Stone

Whenever an opponent discards a card, you may put a quest counter on Quest for the Nihil Stone.
At the beginning of each opponent's upkeep, if that player has no cards in hand and Quest for the Nihil Stone has two or more quest counters on it, you may have that player lose 5 life.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Liliana's Specter

Flying
When Liliana's Specter enters, each opponent discards a card.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Necrogen Mists

At the beginning of each player's upkeep, that player discards a card.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Miasmic Mummy

When Miasmic Mummy enters, each player discards a card.

Burglar Rat

When this creature enters, each opponent discards a card.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Stronghold Rats

Shadow (This creature can block or be blocked by only creatures with shadow.)
Whenever Stronghold Rats deals combat damage to a player, each player discards a card.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Mind Twist

Target player discards X cards at random.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Containment Construct

Whenever you discard a card, you may exile that card from your graveyard. If you do, you may play that card this turn.

Arterial Flow

Each opponent discards two cards. If you control a Vampire, each opponent loses 2 life and you gain 2 life.

Tinybones Joins Up

When Tinybones Joins Up enters, any number of target players each discard a card.
Whenever a legendary creature you control enters, any number of target players each mill a card and lose 1 life.