Liege of the Pit

Flying, trample
At the beginning of your upkeep, sacrifice a creature other than this creature. If you can't, this creature deals 7 damage to you.
Morph {B}{B}{B}{B} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Funeral Rites

You draw two cards, lose 2 life, then mill two cards.

Platinum Emperion

Your life total can't change. (You can't gain or lose life. You can't pay any amount of life except 0.)

Visions of Brutality

Devoid (This card has no color.)
Enchant creature
Enchanted creature can't block.
Whenever enchanted creature deals damage, its controller loses that much life.

Midnight Reaper

Whenever a nontoken creature you control dies, this creature deals 1 damage to you and you draw a card.

Withercrown

Enchant creature
Enchanted creature has base power 0 and has "At the beginning of your upkeep, you lose 1 life unless you sacrifice this creature."

Eternity Vessel

This artifact enters with X charge counters on it, where X is your life total.
Landfall — Whenever a land you control enters, you may have your life total become the number of charge counters on this artifact.

Cruel Bargain

Draw four cards. You lose half your life, rounded up.

Priest of the Blood Rite

When this creature enters, create a 5/5 black Demon creature token with flying.
At the beginning of your upkeep, you lose 2 life.

Acererak the Archlich

When Acererak enters, if you haven't completed Tomb of Annihilation, return Acererak to its owner's hand and venture into the dungeon.
Whenever Acererak attacks, for each opponent, you create a 2/2 black Zombie creature token unless that player sacrifices a creature of their choice.

Isolated Watchtower

{T}: Add {C}.
{2}, {T}: Scry 1, then you may reveal the top card of your library. If a basic land card is revealed this way, put it onto the battlefield tapped. Activate only if an opponent controls at least two more lands than you.

Dusk Legion Zealot

When this creature enters, you draw a card and you lose 1 life.

Takenuma, Abandoned Mire

{T}: Add {B}.
Channel — {3}{B}, Discard this card: Mill three cards, then return a creature or planeswalker card from your graveyard to your hand. This ability costs {1} less to activate for each legendary creature you control.

Toshiro Umezawa

Bushido 1 (Whenever this creature blocks or becomes blocked, it gets +1/+1 until end of turn.)
Whenever a creature an opponent controls dies, you may cast target instant card from your graveyard. If that spell would be put into a graveyard, exile it instead.

Treacherous Blessing

When this enchantment enters, draw three cards.
Whenever you cast a spell, you lose 1 life.
When this enchantment becomes the target of a spell or ability, sacrifice it.

Fretwork Colony

This creature can't block.
At the beginning of your upkeep, put a +1/+1 counter on this creature and you lose 1 life.

Gallowbraid

Trample
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Graf Reaver

Exploit (When this creature enters, you may sacrifice a creature.)
When this creature exploits a creature, destroy target planeswalker.
At the beginning of your upkeep, this creature deals 1 damage to you.

Phyrexian Tower

{T}: Add {C}.
{T}, Sacrifice a creature: Add {B}{B}.

Lord of the Pit

Flying, trample
At the beginning of your upkeep, sacrifice a creature other than this creature. If you can't, this creature deals 7 damage to you.

Nim Abomination

At the beginning of your end step, if this creature is untapped, you lose 3 life.

Painful Lesson

Target player draws two cards and loses 2 life.

Lim-Dûl's Hex

At the beginning of your upkeep, for each player, this enchantment deals 1 damage to that player unless they pay {B} or {3}.

Hasran Ogress

Whenever this creature attacks, it deals 3 damage to you unless you pay {2}.

Thrashing Mudspawn

Whenever this creature is dealt damage, you lose that much life.
Morph {1}{B}{B} (You may cast this card face down as a 2/2 creature for {3}. Turn it face up any time for its morph cost.)

Reaver Drone

Devoid (This card has no color.)
At the beginning of your upkeep, you lose 1 life unless you control another colorless creature.

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Leechridden Swamp

({T}: Add {B}.)
This land enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Hideous End

Destroy target nonblack creature. Its controller loses 2 life.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

The Black Gate

As The Black Gate enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.
{1}{B}, {T}: Choose a player with the most life or tied for most life. Target creature can't be blocked by creatures that player controls this turn.

Foul Imp

Flying
When this creature enters, you lose 2 life.

Live Fast

You draw two cards, lose 2 life, and get {E}{E} (two energy counters).

Ambition's Cost

You draw three cards and you lose 3 life.

Shadows of the Past

Whenever a creature dies, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{4}{B}: Each opponent loses 2 life and you gain 2 life. Activate only if there are four or more creature cards in your graveyard.

Vampire Lacerator

At the beginning of your upkeep, you lose 1 life unless an opponent has 10 or less life.

Xathrid Demon

Flying, trample
At the beginning of your upkeep, sacrifice a creature other than this creature, then each opponent loses life equal to the sacrificed creature's power. If you can't sacrifice a creature, tap this creature and you lose 7 life.

Bellowing Mauler

At the beginning of your end step, each player loses 4 life unless they sacrifice a nontoken creature of their choice.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Dread Reaper

Flying
When this creature enters, you lose 5 life.

Kiku's Shadow

Target creature deals damage to itself equal to its power.

Rain of Daggers

Destroy all creatures target opponent controls. You lose 2 life for each creature destroyed this way.

Soul Bleed

Enchant creature
At the beginning of the upkeep of enchanted creature's controller, that player loses 1 life.

Kezzerdrix

First strike
At the beginning of your upkeep, if your opponents control no creatures, this creature deals 4 damage to you.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Old Flitterfang

Flying
At the beginning of each end step, if a creature died this turn, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this token: You gain 3 life.")
{2}{B}, Sacrifice another creature or artifact: Old Flitterfang gets +2/+2 until end of turn.

Nashi, Moon Sage's Scion

Ninjutsu {3}{B} ({3}{B}, Return an unblocked attacker you control to hand: Put this card onto the battlefield from your hand tapped and attacking.)
Whenever Nashi deals combat damage to a player, exile the top card of each player's library. Until end of turn, you may play one of those cards. If you cast a spell this way, pay life equal to its mana value rather than paying its mana cost.

Blade Juggler

Spectacle {2}{B} (You may cast this spell for its spectacle cost rather than its mana cost if an opponent lost life this turn.)
When this creature enters, it deals 1 damage to you and you draw a card.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Mindwrack Demon

Flying, trample
When this creature enters, mill four cards.
Delirium — At the beginning of your upkeep, you lose 4 life unless there are four or more card types among cards in your graveyard.

Bitter Revelation

Look at the top four cards of your library. Put two of them into your hand and the rest into your graveyard. You lose 2 life.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Reckless Spite

Destroy two target nonblack creatures. You lose 5 life.

Sarcomancy

When this enchantment enters, create a 2/2 black Zombie creature token.
At the beginning of your upkeep, if there are no Zombies on the battlefield, this enchantment deals 1 damage to you.

Night's Whisper

Bellowing Saddlebrute

Raid — When this creature enters, you lose 4 life unless you attacked this turn.

Pain Seer

Inspired — Whenever this creature becomes untapped, reveal the top card of your library and put that card into your hand. You lose life equal to that card's mana value.

Malakir Mire

Malakir Rebirth

Choose target creature. You lose 2 life. Until end of turn, that creature gains "When this creature dies, return it to the battlefield tapped under its owner's control."

Malakir Rebirth // Malakir Mire

Dark Bargain

Look at the top three cards of your library. Put two of them into your hand and the other into your graveyard. Dark Bargain deals 2 damage to you.

Phyrexian Gargantua

When this creature enters, you draw two cards and you lose 2 life.

Eat to Extinction

Exile target creature or planeswalker. Surveil 1. (Look at the top card of your library. You may put that card into your graveyard.)

Archdemon of Greed

Flying, trample
At the beginning of your upkeep, sacrifice a Human. If you can't, tap this creature and it deals 9 damage to you.

Ravenous Demon

Sacrifice a Human: Transform this creature. Activate only as a sorcery.

Ravenous Demon // Archdemon of Greed

The Book of Vile Darkness

At the beginning of your end step, if you lost 2 or more life this turn, create a 2/2 black Zombie creature token.
{T}, Exile The Book of Vile Darkness and artifacts you control named Eye of Vecna and Hand of Vecna: Create Vecna, a legendary 8/8 black Zombie God creature token with indestructible and all triggered abilities of the exiled cards.

Torment of Scarabs

Enchant player
At the beginning of enchanted player's upkeep, that player loses 3 life unless they sacrifice a nonland permanent of their choice or discard a card.

Blessing of Leeches

Flash
Enchant creature
At the beginning of your upkeep, you lose 1 life.
{0}: Regenerate enchanted creature.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Sygg, River Cutthroat

At the beginning of each end step, if an opponent lost 3 or more life this turn, you may draw a card. (Damage causes loss of life.)

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Chainer's Torment

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I, II — This Saga deals 2 damage to each opponent and you gain 2 life.
III — Create an X/X black Nightmare Horror creature token, where X is half your life total, rounded up. It deals X damage to you.

Magus of the Mirror

{T}, Sacrifice this creature: Exchange life totals with target opponent. Activate only during your upkeep.

Morinfen

Flying
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Polluted Mire

This land enters tapped.
{T}: Add {B}.
Cycling {2} ({2}, Discard this card: Draw a card.)

Serpent Warrior

When this creature enters, you lose 3 life.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Gravepurge

Put any number of target creature cards from your graveyard on top of your library.
Draw a card.

Piranha Marsh

This land enters tapped.
When this land enters, target player loses 1 life.
{T}: Add {B}.

Ancient Craving

Dakmor Salvage

This land enters tapped.
{T}: Add {B}.
Dredge 2 (If you would draw a card, you may mill two cards instead. If you do, return this card from your graveyard to your hand.)

Scourge of Numai

At the beginning of your upkeep, you lose 2 life if you don't control an Ogre.

Phyrexian Delver

When this creature enters, return target creature card from your graveyard to the battlefield. You lose life equal to that card's mana value.

Mutilate

All creatures get -1/-1 until end of turn for each Swamp you control.

Wretched Anurid

Whenever another creature enters, you lose 1 life.

Raving Oni-Slave

When this creature enters or leaves the battlefield, you lose 3 life if you don't control a Demon.

Stab Wound

Enchant creature
Enchanted creature gets -2/-2.
At the beginning of the upkeep of enchanted creature's controller, that player loses 2 life.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Flesh Reaver

Whenever this creature deals damage to a creature or opponent, this creature deals that much damage to you.

Spawn of Mayhem

Spectacle {1}{B}{B} (You may cast this spell for its spectacle cost rather than its mana cost if an opponent lost life this turn.)
Flying, trample
At the beginning of your upkeep, this creature deals 1 damage to each player. Then if you have 10 or less life, put a +1/+1 counter on this creature.

Sign in Blood

Barren Moor

This land enters tapped.
{T}: Add {B}.
Cycling {B} ({B}, Discard this card: Draw a card.)

Blood Price

Look at the top four cards of your library. Put two of them into your hand and the rest on the bottom of your library in any order. You lose 2 life.

Treacherous Werewolf

Threshold — As long as seven or more cards are in your graveyard, this creature gets +2/+2 and has "When this creature dies, you lose 4 life."

Erg Raiders

At the beginning of your end step, if this creature didn't attack this turn, it deals 2 damage to you unless it came under your control this turn.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")