Go for the Throat

Phyrexian Obliterator

Trample
Whenever a source deals damage to this creature, that source's controller sacrifices that many permanents of their choice.

Dead of Winter

All nonsnow creatures get -X/-X until end of turn, where X is the number of snow permanents you control.

Swift End

Destroy target creature or planeswalker. You lose 2 life. (Then exile this card. You may cast the creature later from exile.)

Murderous Rider

Lifelink
When this creature dies, put it on the bottom of its owner's library.

Murderous Rider // Swift End

Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice this enchantment: Each opponent loses 3 life. You gain life equal to the life lost this way.

Castle Locthwain

This land enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Cast Down

Liliana's Triumph

Each opponent sacrifices a creature of their choice. If you control a Liliana planeswalker, each opponent also discards a card.

Pitiless Horde

At the beginning of your upkeep, you lose 2 life.
Dash {2}{B}{B} (You may cast this spell for its dash cost. If you do, it gains haste, and it's returned from the battlefield to its owner's hand at the beginning of the next end step.)

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Snow-Covered Swamp

Endling

{B}: This creature gains menace until end of turn.
{B}: This creature gains deathtouch until end of turn.
{B}: This creature gains undying until end of turn. (When this creature dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)
{1}: This creature gets +1/-1 or -1/+1 until end of turn.

Geth's Verdict

Target player sacrifices a creature of their choice and loses 1 life.

Spawn of Mayhem

Spectacle {1}{B}{B} (You may cast this spell for its spectacle cost rather than its mana cost if an opponent lost life this turn.)
Flying, trample
At the beginning of your upkeep, this creature deals 1 damage to each player. Then if you have 10 or less life, put a +1/+1 counter on this creature.

Glint-Sleeve Siphoner

Menace
Whenever this creature enters or attacks, you get {E} (an energy counter).
At the beginning of your upkeep, you may pay {E}{E}. If you do, you draw a card and you lose 1 life.