Aunt May

Whenever another creature you control enters, you gain 1 life. If it's a Spider, put a +1/+1 counter on it.

Doc Ock's Henchmen

Flash
Whenever this creature attacks, it connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on this creature.)

Silver Sable, Mercenary Leader

When Silver Sable enters, put a +1/+1 counter on another target creature.
Whenever Silver Sable attacks, target modified creature you control gains lifelink until end of turn. (Equipment, Auras you control, and counters are modifications.)

Costume Closet

This artifact enters with two +1/+1 counters on it.
{T}: Move a +1/+1 counter from this artifact onto target creature you control. Activate only as a sorcery.
Whenever a modified creature you control leaves the battlefield, put a +1/+1 counter on this artifact. (Equipment, Auras you control, and counters are modifications.)

Beetle, Legacy Criminal

Flying
{1}{U}, Exile this card from your graveyard: Put a +1/+1 counter on target creature. It gains flying until end of turn. Activate only as a sorcery.

Spider-Bot

Reach
When this creature enters, you may search your library for a basic land card, reveal it, then shuffle and put that card on top.

Thwip!

Target creature gets +2/+2 and gains flying until end of turn. If it's a Spider, you gain 2 life.

Mary Jane Watson

Whenever a Spider you control enters, draw a card. This ability triggers only once each turn.

Daily Bugle Reporters

When this creature enters, choose one —
• Puff Piece — Put a +1/+1 counter on each of up to two target creatures.
• Investigative Journalism — Return target creature card with mana value 2 or less from your graveyard to your hand.

Skyward Spider

Ward {2} (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player pays {2}.)
This creature has flying as long as it's modified. (Equipment, Auras you control, and counters are modifications.)

Vibrant Cityscape

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Web Up

When this enchantment enters, exile target nonland permanent an opponent controls until this enchantment leaves the battlefield.

Spectacular Tactics

Choose one —
• Put a +1/+1 counter on target creature you control. It gains hexproof until end of turn.
• Destroy target creature with power 4 or greater.

The Clone Saga

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Surveil 3.
II — When you next cast a creature spell this turn, copy it, except the copy isn't legendary.
III — Choose a card name. Whenever a creature with the chosen name deals combat damage to a player this turn, draw a card.

Spider-Byte, Web Warden

When Spider-Byte enters, return up to one target nonland permanent to its owner's hand.

Daily Bugle Building

{T}: Add {C}.
{1}, {T}: Add one mana of any color.
Smear Campaign — {1}, {T}: Target legendary creature gains menace until end of turn. Activate only as a sorcery.

Bagel and Schmear

Share — {W}, {T}, Sacrifice this artifact: Put a +1/+1 counter on up to one target creature. Draw a card. Activate only as a sorcery.
Nosh — {2}, {T}, Sacrifice this artifact: You gain 3 life and draw a card.

Wild Pack Squad

At the beginning of combat on your turn, up to one target creature gains first strike and vigilance until end of turn.

Spider-Man, Web-Slinger

Web-slinging {W} (You may cast this spell for {W} if you also return a tapped creature you control to its owner's hand.)

Doc Ock, Sinister Scientist

As long as there are eight or more cards in your graveyard, Doc Ock has base power and toughness 8/8.
As long as you control another Villain, Doc Ock has hexproof. (He can't be the target of spells or abilities your opponents control.)

Secret Identity

Choose one —
• Conceal — Until end of turn, target creature you control becomes a Citizen with base power and toughness 1/1 and gains hexproof.
• Reveal — Until end of turn, target creature you control becomes a Hero with base power and toughness 3/4 and gains flying and vigilance.

Spider-Man No More

Enchant creature
Enchanted creature is a Citizen with base power and toughness 1/1. It has defender and loses all other abilities. (It also loses all other creature types.)