Yawgmoth, Thran Physician

Protection from Humans
Pay 1 life, Sacrifice another creature: Put a -1/-1 counter on up to one target creature and draw a card.
{B}{B}, Discard a card: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Bloodthirsty Conqueror

Flying, deathtouch
Whenever an opponent loses life, you gain that much life. (Damage causes loss of life.)

Collector's Vault

{2}, {T}: Draw a card, then discard a card. Create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Vona's Hunger

Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
Each opponent sacrifices a creature of their choice. If you have the city's blessing, instead each opponent sacrifices half the creatures they control of their choice, rounded up.

Fumulus, the Infestation

Flying, deathtouch
Whenever a player sacrifices a nontoken creature, create a 1/1 black Insect creature token with flying.
Whenever an Insect, Leech, Slug, or Worm you control attacks, defending player loses 1 life and you gain 1 life.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Call to the Grave

At the beginning of each player's upkeep, that player sacrifices a non-Zombie creature of their choice.
At the beginning of the end step, if no creatures are on the battlefield, sacrifice this enchantment.

Gix's Command

Choose two —
• Put two +1/+1 counters on up to one creature. It gains lifelink until end of turn.
• Destroy each creature with power 2 or less.
• Return up to two creature cards from your graveyard to your hand.
• Each opponent sacrifices a creature with the greatest power among creatures they control.

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Season of Loss

Choose up to five {P} worth of modes. You may choose the same mode more than once.
{P} — Each player sacrifices a creature of their choice.
{P}{P} — Draw a card for each creature that died under your control this turn.
{P}{P}{P} — Each opponent loses X life, where X is the number of creature cards in your graveyard.

Magus of the Coffers

{2}, {T}: Add {B} for each Swamp you control.

Caged Sun

As this artifact enters, choose a color.
Creatures you control of the chosen color get +1/+1.
Whenever a land's ability causes you to add one or more mana of the chosen color, add an additional one mana of that color.

Grave Pact

Whenever a creature you control dies, each other player sacrifices a creature of their choice.

Greed

Battlefly Swarm

Flying
{B}: This creature gains deathtouch until end of turn.

Taste of Death

Each player sacrifices three creatures of their choice. You create three Food tokens. (They're artifacts with "{2}, {T}, Sacrifice this token: You gain 3 life.")

Sign in Blood

Target player draws two cards and loses 2 life.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to that card's mana value.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Liliana of the Dark Realms

+1: Search your library for a Swamp card, reveal it, put it into your hand, then shuffle.
−3: Target creature gets +X/+X or -X/-X until end of turn, where X is the number of Swamps you control.
−6: You get an emblem with "Swamps you control have '{T}: Add {B}{B}{B}{B}.'"

Sol Ring

Blasphemous Edict

You may pay {B} rather than pay this spell's mana cost if there are thirteen or more creatures on the battlefield.
Each player sacrifices thirteen creatures of their choice.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Vraska's Fall

Each opponent sacrifices a creature or planeswalker of their choice and gets a poison counter.

Hellish Rebuke

Until end of turn, permanents your opponents control gain "When this permanent deals damage to the player who cast Hellish Rebuke, sacrifice this permanent. You lose 2 life."

Dark Ritual

Meathook Massacre II

When Meathook Massacre II enters, each player sacrifices X creatures of their choice.
Whenever a creature you control dies, you may pay 3 life. If you do, return that card under your control with a finality counter on it.
Whenever a creature an opponent controls dies, they may pay 3 life. If they don't, return that card under your control with a finality counter on it.

Choice of Damnations

Target opponent chooses a number. You may have that player lose that much life. If you don't, that player sacrifices all but that many permanents of their choice.

Phyrexian Obliterator

Trample
Whenever a source deals damage to this creature, that source's controller sacrifices that many permanents of their choice.

Bubbling Muck

Until end of turn, whenever a player taps a Swamp for mana, that player adds an additional {B}.

It That Betrays

Annihilator 2 (Whenever this creature attacks, defending player sacrifices two permanents of their choice.)
Whenever an opponent sacrifices a nontoken permanent, put that card onto the battlefield under your control.

Liliana, Dreadhorde General

Whenever a creature you control dies, draw a card.
+1: Create a 2/2 black Zombie creature token.
−4: Each player sacrifices two creatures of their choice.
−9: Each opponent chooses a permanent they control of each permanent type and sacrifices the rest.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Accursed Marauder

When this creature enters, each player sacrifices a nontoken creature of their choice.

Lich-Knights' Conquest

Sacrifice any number of artifacts, enchantments, and/or tokens. Return that many creature cards from your graveyard to the battlefield.

Rottenmouth Viper

As an additional cost to cast this spell, you may sacrifice any number of nonland permanents. This spell costs {1} less to cast for each permanent sacrificed this way.
Whenever this creature enters or attacks, put a blight counter on it. Then for each blight counter on it, each opponent loses 4 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Geth's Verdict

Target player sacrifices a creature of their choice and loses 1 life.

Plaguecrafter

When this creature enters, each player sacrifices a creature or planeswalker of their choice. Each player who can't discards a card.

Village Rites

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Innocent Blood

Each player sacrifices a creature of their choice.

Roaming Throne

Ward {2}
As this creature enters, choose a creature type.
This creature is the chosen type in addition to its other types.
If a triggered ability of another creature you control of the chosen type triggers, it triggers an additional time.

Halo Scarab

{2}, Exile this card from your graveyard: Create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Tortured Existence

{B}, Discard a creature card: Return target creature card from your graveyard to your hand.

Ulamog, the Defiler

When you cast this spell, target opponent exiles the top half of their library, rounded up.
Ward—Sacrifice two permanents.
Ulamog enters with a number of +1/+1 counters on it equal to the greatest mana value among cards in exile.
Ulamog has annihilator X, where X is the number of +1/+1 counters on it.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Blood Artist

Whenever this creature or another creature dies, target player loses 1 life and you gain 1 life.

Mortician Beetle

Whenever a player sacrifices a creature, you may put a +1/+1 counter on this creature.

Cabal Coffers

Phyrexian Altar

Sacrifice a creature: Add one mana of any color.

Swamp

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Canoptek Scarab Swarm

Flying
Feeder Mandibles — When this creature enters, exile target player's graveyard. For each artifact or land card exiled this way, create a 1/1 colorless Insect artifact creature token with flying.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature of their choice.
• Each opponent sacrifices a creature token of their choice.
• Each opponent sacrifices a planeswalker of their choice.

Ashnod's Altar

Dark Confidant

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Diabolic Edict

Target player sacrifices a creature of their choice.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Tribute to Hunger

Target opponent sacrifices a creature of their choice. You gain life equal to that creature's toughness.

Rankle's Prank

Choose one or more —
• Each player discards two cards.
• Each player loses 4 life.
• Each player sacrifices two creatures of their choice.

Zulaport Cutthroat

Whenever this creature or another creature you control dies, each opponent loses 1 life and you gain 1 life.

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Takenuma, Abandoned Mire

{T}: Add {B}.
Channel — {3}{B}, Discard this card: Mill three cards, then return a creature or planeswalker card from your graveyard to your hand. This ability costs {1} less to activate for each legendary creature you control.

Fleshbag Marauder

When this creature enters, each player sacrifices a creature of their choice.

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Anowon, the Ruin Sage

At the beginning of your upkeep, each player sacrifices a non-Vampire creature of their choice.

Sephiroth, One-Winged Angel

Flying
Super Nova — As this creature transforms into Sephiroth, One-Winged Angel, you get an emblem with "Whenever a creature dies, target opponent loses 1 life and you gain 1 life."
Whenever Sephiroth attacks, you may sacrifice any number of other creatures. If you do, draw that many cards.

Sephiroth, Fabled SOLDIER

Whenever Sephiroth enters or attacks, you may sacrifice another creature. If you do, draw a card.
Whenever another creature dies, target opponent loses 1 life and you gain 1 life. If this is the fourth time this ability has resolved this turn, transform Sephiroth.

Sephiroth, Fabled SOLDIER // Sephiroth, One-Winged Angel

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Invoke Despair

Target opponent sacrifices a creature of their choice. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Circuit Mender

When this creature enters, you gain 2 life.
When this creature leaves the battlefield, draw a card.

Soul Shatter

Each opponent sacrifices a creature or planeswalker with the greatest mana value among creatures and planeswalkers they control.