Sign in Blood

Target player draws two cards and loses 2 life.

Stronghold Assassin

{T}, Sacrifice a creature: Destroy target nonblack creature.

Skullclamp

Equipped creature gets +1/-1.
Whenever equipped creature dies, draw two cards.
Equip {1}

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Species Specialist

As Species Specialist enters, choose a creature type.
Whenever a creature of the chosen type dies, you may draw a card.

Shadowborn Demon

Flying
When Shadowborn Demon enters, destroy target non-Demon creature.
At the beginning of your upkeep, if there are fewer than six creature cards in your graveyard, sacrifice a creature.

Shirei, Shizo's Caretaker

Whenever a creature with power 1 or less is put into your graveyard from the battlefield, you may return that card to the battlefield at the beginning of the next end step if Shirei, Shizo's Caretaker is still on the battlefield.

Skeletal Scrying

As an additional cost to cast this spell, exile X cards from your graveyard.
You draw X cards and you lose X life.

Sower of Discord

Flying
As Sower of Discord enters, choose two players.
Whenever damage is dealt to one of the chosen players, the other chosen player also loses that much life.

Syr Konrad, the Grim

Whenever another creature dies, or a creature card is put into a graveyard from anywhere other than the battlefield, or a creature card leaves your graveyard, Syr Konrad, the Grim deals 1 damage to each opponent.
{1}{B}: Each player mills a card. (They each put the top card of their library into their graveyard.)

Scavenger Grounds

{T}: Add {C}.
{2}, {T}, Sacrifice a Desert: Exile all graveyards.

Scheming Symmetry

Choose two target players. Each of them searches their library for a card, then shuffles and puts that card on top.

Strands of Night

{B}{B}, Pay 2 life, Sacrifice a Swamp: Return target creature card from your graveyard to the battlefield.

Sword of Fire and Ice

Equipped creature gets +2/+2 and has protection from red and from blue.
Whenever equipped creature deals combat damage to a player, Sword of Fire and Ice deals 2 damage to any target and you draw a card.
Equip {2}

Swamp

Sidisi, Undead Vizier

Deathtouch
Exploit (When this creature enters, you may sacrifice a creature.)
When Sidisi, Undead Vizier exploits a creature, you may search your library for a card, put it into your hand, then shuffle.

Secret Salvage

Exile target nonland card from your graveyard. Search your library for any number of cards with the same name as that card, reveal them, put them into your hand, then shuffle.

Skirsdag Flayer

{3}{B}, {T}, Sacrifice a Human: Destroy target creature.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Slate of Ancestry

{4}, {T}, Discard your hand: Draw a card for each creature you control.

Sudden Spoiling

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Until end of turn, creatures target player controls lose all abilities and have base power and toughness 0/2.

Surgical Extraction

({B/P} can be paid with either {B} or 2 life.)
Choose target card in a graveyard other than a basic land card. Search its owner's graveyard, hand, and library for any number of cards with the same name as that card and exile them. Then that player shuffles.

Smuggler's Copter

Flying
Whenever Smuggler's Copter attacks or blocks, you may draw a card. If you do, discard a card.
Crew 1 (Tap any number of creatures you control with total power 1 or more: This Vehicle becomes an artifact creature until end of turn.)

Shadowborn Apostle

A deck can have any number of cards named Shadowborn Apostle.
{B}, Sacrifice six creatures named Shadowborn Apostle: Search your library for a Demon creature card, put it onto the battlefield, then shuffle.

Sol Ring

Sword of Light and Shadow

Equipped creature gets +2/+2 and has protection from white and from black.
Whenever equipped creature deals combat damage to a player, you gain 3 life and you may return up to one target creature card from your graveyard to your hand.
Equip {2}

Smothering Abomination

Devoid (This card has no color.)
Flying
At the beginning of your upkeep, sacrifice a creature.
Whenever you sacrifice a creature, draw a card.