Kraum, Ludevic's Opus

Flying, haste
Whenever an opponent casts their second spell each turn, draw a card.
Partner (You can have two commanders if both have partner.)

Eris, Roar of the Storm

This spell costs {2} less to cast for each different mana value among instant and sorcery cards in your graveyard.
Flying, prowess
Whenever you cast your second spell each turn, create a 4/4 red Dragon Elemental creature token with flying and prowess.

Shadow of the Second Sun

Enchant player
At the beginning of each of enchanted player's postcombat main phases, there is an additional beginning phase after this phase. (The end step happens after the added untap, upkeep, and draw steps.)

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Second Guess

Counter target spell that's the second spell cast this turn.

Kraum, Violent Cacophony

Flying
Whenever you cast your second spell each turn, put a +1/+1 counter on Kraum and draw a card.

Faerie Vandal

Flash (You may cast this spell any time you could cast an instant.)
Flying
Whenever you draw your second card each turn, put a +1/+1 counter on this creature.

Sphinx of the Second Sun

Flying
At the beginning of each of your postcombat main phases, there is an additional beginning phase after this phase. (The beginning phase includes the untap, upkeep, and draw steps.)

Raging Battle Mouse

The second spell you cast each turn costs {1} less to cast.
Celebration — At the beginning of combat on your turn, if two or more nonland permanents entered the battlefield under your control this turn, target creature you control gets +1/+1 until end of turn.

Irencrag Pyromancer

Whenever you draw your second card each turn, this creature deals 3 damage to any target.

Time Stretch

Target player takes two extra turns after this one.

Ledger Shredder

Flying
Whenever a player casts their second spell each turn, this creature connives. (Draw a card, then discard a card. If you discarded a nonland card, put a +1/+1 counter on this creature.)

Homunculus Horde

Whenever you draw your second card each turn, create a token that's a copy of this creature.

V.A.T.S.

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Choose any number of target creatures with equal toughness. Destroy the chosen creatures.

Dogged Detective

When this creature enters, surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)
Whenever an opponent draws their second card each turn, you may return this card from your graveyard to your hand.

Untimely Malfunction

Choose one —
• Destroy target artifact.
• Change the target of target spell or ability with a single target.
• One or two target creatures can't block this turn.

Jori En, Ruin Diver

Whenever you cast your second spell each turn, draw a card.

Faerie Mastermind

Flash
Flying
Whenever an opponent draws their second card each turn, you draw a card.
{3}{U}: Each player draws a card.

Emrakul's Messenger

Devoid (This card has no color.)
Flying
Whenever you draw your second card each turn, create a 0/1 colorless Eldrazi Spawn creature token with "Sacrifice this token: Add {C}."

Alandra, Sky Dreamer

Whenever you draw your second card each turn, create a 2/2 blue Drake creature token with flying.
Whenever you draw your fifth card each turn, Alandra and Drakes you control each get +X/+X until end of turn, where X is the number of cards in your hand.

Ashling, Flame Dancer

You don't lose unspent red mana as steps and phases end.
Magecraft — Whenever you cast or copy an instant or sorcery spell, discard a card, then draw a card. If this is the second time this ability has resolved this turn, Ashling deals 2 damage to each opponent and each creature they control. If it's the third time, add {R}{R}{R}{R}.

Brimstone Roundup

Whenever you cast your second spell each turn, create a 1/1 red Mercenary creature token with "{T}: Target creature you control gets +1/+0 until end of turn. Activate only as a sorcery."
Plot {2}{R} (You may pay {2}{R} and exile this card from your hand. Cast it as a sorcery on a later turn without paying its mana cost. Plot only as a sorcery.)

Obeka, Splitter of Seconds

Menace
Whenever Obeka deals combat damage to a player, you get that many additional upkeep steps after this phase.

Bloodsky Berserker

Whenever you cast your second spell each turn, put two +1/+1 counters on this creature. It gains menace until end of turn. (It can't be blocked except by two or more creatures.)

Stella Lee, Wild Card

Whenever you cast your second spell each turn, exile the top card of your library. Until the end of your next turn, you may play that card.
{T}: Copy target instant or sorcery spell you control. You may choose new targets for the copy. Activate only if you've cast three or more spells this turn.

Malcolm, the Eyes

Flying, haste
Whenever you cast your second spell each turn, investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this token: Draw a card.")

Time Stop

End the turn. (Exile all spells and abilities, including this spell. The player whose turn it is discards down to their maximum hand size. Damage heals and "this turn" and "until end of turn" effects end.)

Telling Time

Look at the top three cards of your library. Put one of those cards into your hand, one on top of your library, and one on the bottom of your library.

Second Wind

Enchant creature
{T}: Tap enchanted creature.
{T}: Untap enchanted creature.

Stitch in Time

Flip a coin. If you win the flip, take an extra turn after this one.

Minn, Wily Illusionist

Whenever you draw your second card each turn, create a 1/1 blue Illusion creature token with "This token gets +1/+0 for each other Illusion you control."
Whenever an Illusion you control dies, you may put a permanent card with mana value less than or equal to that creature's power from your hand onto the battlefield.

Shackle Slinger

Whenever you cast your second spell each turn, choose target creature an opponent controls. If it's tapped, put a stun counter on it. Otherwise, tap it. (If a permanent with a stun counter would become untapped, remove one from it instead.)

Storm of Saruman

Ward {3}
Whenever you cast your second spell each turn, copy it, except the copy isn't legendary. You may choose new targets for the copy. (A copy of a permanent spell becomes a token.)

Improbable Alliance

Whenever you draw your second card each turn, create a 1/1 blue Faerie creature token with flying.
{4}{U}{R}: Draw a card, then discard a card.

Timely Interference

Kicker {1}{R} (You may pay an additional {1}{R} as you cast this spell.)
Target creature gets -1/-0 until end of turn. If this spell was kicked, that creature blocks this turn if able.
Draw a card.

Ill-Timed Explosion

Draw two cards. Then you may discard two cards. When you do, Ill-Timed Explosion deals X damage to each creature, where X is the greatest mana value among cards discarded this way.

Deem Inferior

This spell costs {1} less to cast for each card you've drawn this turn.
The owner of target nonland permanent puts it into their library second from the top or on the bottom.