Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Dragonskull Summit

Dragonskull Summit enters the battlefield tapped unless you control a Swamp or a Mountain.
{T}: Add {B} or {R}.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Bedevil

Destroy target artifact, creature, or planeswalker.

Shard of the Nightbringer

Flying
Drain Life — When Shard of the Nightbringer enters the battlefield, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Badlands

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Deflecting Swat

If you control a commander, you may cast this spell without paying its mana cost.
You may choose new targets for target spell or ability.

Blood Crypt

({T}: Add {B} or {R}.)
As Blood Crypt enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Soul Channeling

Enchant creature
Pay 2 life: Regenerate enchanted creature.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Harnfel, Horn of Bounty

Discard a card: Exile the top two cards of your library. You may play those cards this turn.

Birgi, God of Storytelling

Whenever you cast a spell, add {R}. Until end of turn, you don't lose this mana as steps and phases end.
Creatures you control can boast twice during each of your turns rather than once.

Birgi, God of Storytelling // Harnfel, Horn of Bounty

Treasonous Ogre

Dethrone (Whenever this creature attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)
Pay 3 life: Add {R}.

War Room

{T}: Add {C}.
{3}, {T}, Pay life equal to the number of colors in your commanders' color identity: Draw a card.

Fire Covenant

As an additional cost to cast this spell, pay X life.
Fire Covenant deals X damage divided as you choose among any number of target creatures.

Bitter Triumph

As an additional cost to cast this spell, discard a card or pay 3 life.
Destroy target creature or planeswalker.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Ancient Tomb

{T}: Add {C}{C}. Ancient Tomb deals 2 damage to you.

Crackle with Power

Crackle with Power deals five times X damage to each of up to X targets.

City of Brass

Whenever City of Brass becomes tapped, it deals 1 damage to you.
{T}: Add one mana of any color.

Ramunap Ruins

{T}: Add {C}.
{T}, Pay 1 life: Add {R}.
{2}{R}{R}, {T}, Sacrifice a Desert: Ramunap Ruins deals 2 damage to each opponent.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Cursed Mirror

{T}: Add {R}.
As Cursed Mirror enters the battlefield, you may have it become a copy of any creature on the battlefield until end of turn, except it has haste.

Mizzix's Mastery

Exile target card that's an instant or sorcery from your graveyard. For each card exiled this way, copy it, and you may cast the copy without paying its mana cost. Exile Mizzix's Mastery.
Overload {5}{R}{R}{R} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Mithril Coat

Flash
Indestructible
When Mithril Coat enters the battlefield, attach it to target legendary creature you control.
Equipped creature has indestructible.
Equip {3}

Chaos Warp

The owner of target permanent shuffles it into their library, then reveals the top card of their library. If it's a permanent card, they put it onto the battlefield.

Rowan, Scion of War

Menace
{T}: Spells you cast this turn that are black and/or red cost {X} less to cast, where X is the amount of life you lost this turn. Activate only as a sorcery.

Ribbons

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Each opponent loses X life.

Cut // Ribbons

Night's Whisper

Storm-Kiln Artist

Storm-Kiln Artist gets +1/+0 for each artifact you control.
Magecraft — Whenever you cast or copy an instant or sorcery spell, create a Treasure token.

Talisman of Indulgence

{T}: Add {C}.
{T}: Add {B} or {R}. Talisman of Indulgence deals 1 damage to you.

Bloodstained Mire

{T}, Pay 1 life, Sacrifice Bloodstained Mire: Search your library for a Swamp or Mountain card, put it onto the battlefield, then shuffle.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Storm King's Thunder

When you next cast an instant or sorcery spell this turn, copy that spell X times. You may choose new targets for the copies.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Electrodominance

Electrodominance deals X damage to any target. You may cast a spell with mana value X or less from your hand without paying its mana cost.

Rakdos Signet

Thousand-Year Elixir

You may activate abilities of creatures you control as though those creatures had haste.
{1}, {T}: Untap target creature.

Call Forth the Tempest

Cascade, cascade (When you cast this spell, exile cards from the top of your library until you exile a nonland card that costs less. You may cast it without paying its mana cost. Put the exiled cards on the bottom of your library in a random order. Then do it again.)
Call Forth the Tempest deals damage to each creature your opponents control equal to the total mana value of other spells you've cast this turn.

City on Fire

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
If a source you control would deal damage to a permanent or player, it deals triple that damage instead.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Solphim, Mayhem Dominus

If a source you control would deal noncombat damage to an opponent or a permanent an opponent controls, it deals double that damage to that player or permanent instead.
{1}{R/P}{R/P}, Discard two cards: Put an indestructible counter on Solphim, Mayhem Dominus. ({R/P} can be paid with either {R} or 2 life.)

Sulfurous Springs

{T}: Add {C}.
{T}: Add {B} or {R}. Sulfurous Springs deals 1 damage to you.

Black Market Connections

At the beginning of your precombat main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Read the Bones

Scry 2, then draw two cards. You lose 2 life.

Sol Ring

Sign in Blood

Target player draws two cards and loses 2 life.

Immolating Souleater

{R/P}: Immolating Souleater gets +1/+0 until end of turn. ({R/P} can be paid with either {R} or 2 life.)

Moltensteel Dragon

({R/P} can be paid with either {R} or 2 life.)
Flying
{R/P}: Moltensteel Dragon gets +1/+0 until end of turn.

The Black Gate

As The Black Gate enters the battlefield, you may pay 3 life. If you don't, it enters the battlefield tapped.
{T}: Add {B}.
{1}{B}, {T}: Choose a player with the most life or tied for most life. Target creature can't be blocked by creatures that player controls this turn.

Command Tower

Foreboding Ruins

As Foreboding Ruins enters the battlefield, you may reveal a Swamp or Mountain card from your hand. If you don't, Foreboding Ruins enters the battlefield tapped.
{T}: Add {B} or {R}.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Shivan Devastator

Flying, haste
Shivan Devastator enters the battlefield with X +1/+1 counters on it.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Blood Pact

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Defiler of Instinct

First strike
As an additional cost to cast red permanent spells, you may pay 2 life. Those spells cost {R} less to cast if you paid life this way. This effect reduces only the amount of red mana you pay.
Whenever you cast a red permanent spell, Defiler of Instinct deals 1 damage to any target.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Mount Doom

{T}, Pay 1 life: Add {B} or {R}.
{1}{B}{R}, {T}: Mount Doom deals 1 damage to each opponent.
{5}{B}{R}, {T}, Sacrifice Mount Doom and a legendary artifact: Choose up to two creatures, then destroy the rest. Activate only as a sorcery.

Delete

Delete deals X damage to each nonartifact creature and each player.

Terminate

Destroy target creature. It can't be regenerated.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Patriar's Seal

{T}: Add one mana of any color.
{1}, {T}: Untap target legendary creature you control.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Staff of Compleation

{T}, Pay 1 life: Destroy target permanent you own.
{T}, Pay 2 life: Add one mana of any color.
{T}, Pay 3 life: Proliferate.
{T}, Pay 4 life: Draw a card.
{5}: Untap Staff of Compleation.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters the battlefield, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Jaya's Immolating Inferno

(You may cast a legendary sorcery only if you control a legendary creature or planeswalker.)
Jaya's Immolating Inferno deals X damage to each of up to three targets.

Mountain

Ifnir Deadlands

{T}: Add {C}.
{T}, Pay 1 life: Add {B}.
{2}{B}{B}, {T}, Sacrifice a Desert: Put two -1/-1 counters on target creature an opponent controls. Activate only as a sorcery.

Mana Confluence

{T}, Pay 1 life: Add one mana of any color.

Swamp

Comet Storm

Multikicker {1} (You may pay an additional {1} any number of times as you cast this spell.)
Choose any target, then choose another target for each time this spell was kicked. Comet Storm deals X damage to each of them.

Hall of the Bandit Lord

Hall of the Bandit Lord enters the battlefield tapped.
{T}, Pay 3 life: Add {C}. If that mana is spent on a creature spell, it gains haste.

Greed

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Battle at the Bridge

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Target creature gets -X/-X until end of turn. You gain X life.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Manabarbs

Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player.

Dockside Extortionist

When Dockside Extortionist enters the battlefield, create X Treasure tokens, where X is the number of artifacts and enchantments your opponents control. (Treasure tokens are artifacts with "{T}, Sacrifice this artifact: Add one mana of any color.")