Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Swamp

Drivnod, Carnage Dominus

If a creature dying causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
{B/P}{B/P}, Exile three creature cards from your graveyard: Put an indestructible counter on Drivnod, Carnage Dominus. ({B/P} can be paid with either {B} or 2 life.)

Eiganjo, Seat of the Empire

{T}: Add {W}.
Channel — {2}{W}, Discard Eiganjo, Seat of the Empire: It deals 4 damage to target attacking or blocking creature. This ability costs {1} less to activate for each legendary creature you control.

Despark

Exile target permanent with mana value 4 or greater.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Orzhov Signet

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Evolving Wilds

{T}, Sacrifice Evolving Wilds: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Blood Artist

Whenever Blood Artist or another creature dies, target player loses 1 life and you gain 1 life.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Ancient Tomb

{T}: Add {C}{C}. Ancient Tomb deals 2 damage to you.

Cruel Celebrant

Whenever Cruel Celebrant or another creature or planeswalker you control dies, each opponent loses 1 life and you gain 1 life.

Gollum, Obsessed Stalker

Skulk (This creature can't be blocked by creatures with greater power.)
At the beginning of your end step, each opponent dealt combat damage this game by a creature named Gollum, Obsessed Stalker loses life equal to the amount of life you gained this turn.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Orzhov Cluestone

{T}: Add {W} or {B}.
{W}{B}, {T}, Sacrifice Orzhov Cluestone: Draw a card.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Nykthos Paragon

Whenever you gain life, you may put that many +1/+1 counters on each creature you control. Do this only once each turn.

Starscream, Seeker Leader

Living metal (As long as it's your turn, this Vehicle is also a creature.)
Flying, menace, haste
Whenever Starscream deals combat damage to a player, if there is no monarch, that player becomes the monarch.
Whenever you become the monarch, convert Starscream.

Starscream, Power Hungry

More Than Meets the Eye {2}{B} (You may cast this card converted for {2}{B}.)
Flying
Whenever you draw a card, if you're the monarch, target opponent loses 2 life.
Whenever one or more creatures deal combat damage to you, convert Starscream.

Starscream, Power Hungry // Starscream, Seeker Leader

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Soul Warden

Whenever another creature enters the battlefield, you gain 1 life.

Suture Priest

Whenever another creature enters the battlefield under your control, you may gain 1 life.
Whenever a creature enters the battlefield under an opponent's control, you may have that player lose 1 life.

Pact of the Serpent

Choose a creature type. Target player draws X cards and loses X life, where X is the number of creatures they control of the chosen type.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Obzedat, Ghost Council

When Obzedat, Ghost Council enters the battlefield, target opponent loses 2 life and you gain 2 life.
At the beginning of your end step, you may exile Obzedat. If you do, return it to the battlefield under its owner's control at the beginning of your next upkeep. It gains haste.

Kinzu of the Bleak Coven

Flying
Whenever another nontoken creature you control dies, you may pay 2 life and exile it. If you do, create a token that's a copy of that creature, except it's 1/1 and has toxic 1. (Players dealt combat damage by it also get a poison counter.)

Cryptic Spires

As you create your deck, circle two of the colors below.
Cryptic Spires enters the battlefield tapped.
{T}: Add one mana of either of the circled colors.

Forsaken Sanctuary

Forsaken Sanctuary enters the battlefield tapped.
{T}: Add {W} or {B}.

Ephemerate

Exile target creature you control, then return it to the battlefield under its owner's control.
Rebound (If you cast this spell from your hand, exile it as it resolves. At the beginning of your next upkeep, you may cast this card from exile without paying its mana cost.)

Scrubland

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Kaya the Inexorable

+1: Put a ghostform counter on up to one target nontoken creature. It gains "When this creature dies or is put into exile, return it to its owner's hand and create a 1/1 white Spirit creature token with flying."
−3: Exile target nonland permanent.
−7: You get an emblem with "At the beginning of your upkeep, you may cast a legendary spell from your hand, from your graveyard, or from among cards you own in exile without paying its mana cost."

Greed

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Corpse Knight

Whenever another creature enters the battlefield under your control, each opponent loses 1 life.

Akroma's Will

Choose one. If you control a commander as you cast this spell, you may choose both instead.
• Creatures you control gain flying, vigilance, and double strike until end of turn.
• Creatures you control gain lifelink, indestructible, and protection from all colors until end of turn.

Thran Foundry

{1}, {T}, Exile Thran Foundry: Target player shuffles their graveyard into their library.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Kaya, Intangible Slayer

Hexproof
+2: Each opponent loses 3 life and you gain 3 life.
0: You draw two cards. Then each opponent may scry 1.
−3: Exile target creature or enchantment. If it wasn't an Aura, create a token that's a copy of it, except it's a 1/1 white Spirit creature with flying in addition to its other types.

Archivist of Oghma

Flash
Whenever an opponent searches their library, you gain 1 life and draw a card.

Finish

Aftermath (Cast this spell only from your graveyard. Then exile it.)
As an additional cost to cast Finish, sacrifice a creature.
Destroy target creature.

Start

Create two 1/1 white Warrior creature tokens with vigilance.

Start // Finish

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Fiend Hunter

When Fiend Hunter enters the battlefield, you may exile another target creature.
When Fiend Hunter leaves the battlefield, return the exiled card to the battlefield under its owner's control.

Soul's Attendant

Whenever another creature enters the battlefield, you may gain 1 life.

Profane Tutor

Suspend 2—{1}{B} (Rather than cast this card from your hand, pay {1}{B} and exile it with two time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)
Search your library for a card, put that card into your hand, then shuffle.

Norn's Annex

({W/P} can be paid with either {W} or 2 life.)
Creatures can't attack you or planeswalkers you control unless their controller pays {W/P} for each of those creatures.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Court of Ambition

When Court of Ambition enters the battlefield, you become the monarch.
At the beginning of your upkeep, each opponent loses 3 life unless they discard a card. If you're the monarch, instead each opponent loses 6 life unless they discard two cards.

Lux Cannon

{T}: Put a charge counter on Lux Cannon.
{T}, Remove three charge counters from Lux Cannon: Destroy target permanent.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Dawn Charm

Choose one —
• Prevent all combat damage that would be dealt this turn.
• Regenerate target creature.
• Counter target spell that targets you.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Crush Contraband

Choose one or both —
• Exile target artifact.
• Exile target enchantment.

Rhox Faithmender

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
If you would gain life, you gain twice that much life instead.

Perilous Vault

{5}, {T}, Exile Perilous Vault: Exile all nonland permanents.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Marsh Flats

{T}, Pay 1 life, Sacrifice Marsh Flats: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Mana Confluence

{T}, Pay 1 life: Add one mana of any color.

Astarion, the Decadent

Deathtouch, lifelink
At the beginning of your end step, choose one —
• Feed — Target opponent loses life equal to the amount of life they lost this turn.
• Friends — You gain life equal to the amount of life you gained this turn.

Orzhov Locket

{T}: Add {W} or {B}.
{W/B}{W/B}{W/B}{W/B}, {T}, Sacrifice Orzhov Locket: Draw two cards.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Aetherflux Reservoir

Whenever you cast a spell, you gain 1 life for each spell you've cast this turn.
Pay 50 life: Aetherflux Reservoir deals 50 damage to any target.

Plains

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature enters the battlefield under your control, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Angelic Accord

At the beginning of each end step, if you gained 4 or more life this turn, create a 4/4 white Angel creature token with flying.

Day of Judgment

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Tivash, Gloom Summoner

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay X life, where X is the amount of life you gained this turn. If you do, create an X/X black Demon creature token with flying.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters the battlefield, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Plague Reaver

At the beginning of your end step, sacrifice each other creature you control.
Discard two cards, Sacrifice Plague Reaver: Choose target opponent. Return Plague Reaver to the battlefield under that player's control at the beginning of their next upkeep.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Drana's Emissary

Flying
At the beginning of your upkeep, each opponent loses 1 life and you gain 1 life.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Windborn Muse

Flying
Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.