Ritual of Soot

Destroy all creatures with mana value 3 or less.

Damnation

Destroy all creatures. They can't be regenerated.

Vishgraz, the Doomhive

Menace, toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
When Vishgraz, the Doomhive enters, create three 1/1 colorless Phyrexian Mite artifact creature tokens with toxic 1 and "This creature can't block."
Vishgraz gets +1/+1 for each poison counter your opponents have.

No Witnesses

Each player who controls the most creatures investigates. Then destroy all creatures. (To investigate, create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Wrath of God

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.

Day of Judgment

Depopulate

Each player who controls a multicolored creature draws a card. Then destroy all creatures.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Damn

Destroy target creature. A creature destroyed this way can't be regenerated.
Overload {2}{W}{W} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Doomskar

Destroy all creatures.
Foretell {1}{W}{W} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Vraska's Fall

Each opponent sacrifices a creature or planeswalker of their choice and gets a poison counter.

Ichor Rats

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
When Ichor Rats enters, each player gets a poison counter.

Far Traveler

Commander creatures you own have "At the beginning of your end step, exile up to one target tapped creature you control, then return it to the battlefield under its owner's control."

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