Smokestack

At the beginning of your upkeep, you may put a soot counter on Smokestack.
At the beginning of each player's upkeep, that player sacrifices a permanent of their choice for each soot counter on Smokestack.

Mindslaver

{4}, {T}, Sacrifice Mindslaver: You control target player during that player's next turn. (You see all cards that player could see and make all decisions for the player.)

Desolation

At the beginning of each end step, each player who tapped a land for mana this turn sacrifices a land of their choice. Desolation deals 2 damage to each player who sacrificed a Plains this way.

Tainted Aether

Whenever a creature enters, its controller sacrifices a creature or land of their choice.

Storage Matrix

As long as Storage Matrix is untapped, each player chooses artifact, creature, or land during their untap step. That player can untap only permanents of the chosen type this step.

Defense Grid

Each spell costs {3} more to cast except during its controller's turn.

Energy Flux

All artifacts have "At the beginning of your upkeep, sacrifice this artifact unless you pay {2}."

Opposition Agent

Flash
You control your opponents while they're searching their libraries.
While an opponent is searching their library, they exile each card they find. You may play those cards for as long as they remain exiled, and you may spend mana as though it were mana of any color to cast them.

World Shaper

Whenever World Shaper attacks, you may mill three cards.
When World Shaper dies, return all land cards from your graveyard to the battlefield tapped.

Haywire Mite

When Haywire Mite dies, you gain 2 life.
{G}, Sacrifice Haywire Mite: Exile target noncreature artifact or noncreature enchantment.

Pernicious Deed

{X}, Sacrifice Pernicious Deed: Destroy each artifact, creature, and enchantment with mana value X or less.

Hostage Taker

When Hostage Taker enters, exile another target creature or artifact until Hostage Taker leaves the battlefield. You may cast that card for as long as it remains exiled, and mana of any type can be spent to cast that spell.

Foundation Breaker

When Foundation Breaker enters, you may destroy target artifact or enchantment.
Evoke {1}{G} (You may cast this spell for its evoke cost. If you do, it's sacrificed when it enters.)

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Narset, Parter of Veils

Each opponent can't draw more than one card each turn.
−2: Look at the top four cards of your library. You may reveal a noncreature, nonland card from among them and put it into your hand. Put the rest on the bottom of your library in a random order.

Ashiok, Dream Render

Spells and abilities your opponents control can't cause their controller to search their library.
−1: Target player mills four cards. Then exile each opponent's graveyard.

Liliana, Dreadhorde General

Whenever a creature you control dies, draw a card.
+1: Create a 2/2 black Zombie creature token.
−4: Each player sacrifices two creatures of their choice.
−9: Each opponent chooses a permanent they control of each permanent type and sacrifices the rest.

Caustic Caterpillar

{1}{G}, Sacrifice Caustic Caterpillar: Destroy target artifact or enchantment.

Mystic Remora

Cumulative upkeep {1} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
Whenever an opponent casts a noncreature spell, you may draw a card unless that player pays {4}.

Jarad, Golgari Lich Lord

Jarad, Golgari Lich Lord gets +1/+1 for each creature card in your graveyard.
{1}{B}{G}, Sacrifice another creature: Each opponent loses life equal to the sacrificed creature's power.
Sacrifice a Swamp and a Forest: Return Jarad from your graveyard to your hand.

Seal of Removal

Sacrifice Seal of Removal: Return target creature to its owner's hand.

Defense of the Heart

At the beginning of your upkeep, if an opponent controls three or more creatures, sacrifice Defense of the Heart, search your library for up to two creature cards, put those cards onto the battlefield, then shuffle.

Sinister Concoction

{B}, Pay 1 life, Mill a card, Discard a card, Sacrifice Sinister Concoction: Destroy target creature.

Glacial Chasm

Cumulative upkeep—Pay 2 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
When Glacial Chasm enters, sacrifice a land.
Creatures you control can't attack.
Prevent all damage that would be dealt to you.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Mazirek, Kraul Death Priest

Flying
Whenever a player sacrifices another permanent, put a +1/+1 counter on each creature you control.

Wonder

Flying
As long as Wonder is in your graveyard and you control an Island, creatures you control have flying.

Vile Entomber

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
When this creature enters, search your library for a card, put that card into your graveyard, then shuffle.

Old Rutstein

When Old Rutstein enters and at the beginning of your upkeep, mill a card. If a land card is milled this way, create a Treasure token. If a creature card is milled this way, create a 1/1 green Insect creature token. If a noncreature, nonland card is milled this way, create a Blood token.

The Gitrog Monster

Deathtouch
At the beginning of your upkeep, sacrifice The Gitrog Monster unless you sacrifice a land.
You may play an additional land on each of your turns.
Whenever one or more land cards are put into your graveyard from anywhere, draw a card.

Mikaeus, the Unhallowed

Intimidate (This creature can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever a Human deals damage to you, destroy it.
Other non-Human creatures you control get +1/+1 and have undying. (When a creature with undying dies, if it had no +1/+1 counters on it, return it to the battlefield under its owner's control with a +1/+1 counter on it.)

Thassa's Oracle

When Thassa's Oracle enters, look at the top X cards of your library, where X is your devotion to blue. Put up to one of them on top of your library and the rest on the bottom of your library in a random order. If X is greater than or equal to the number of cards in your library, you win the game. (Each {U} in the mana costs of permanents you control counts toward your devotion to blue.)

Laboratory Maniac

If you would draw a card while your library has no cards in it, you win the game instead.

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature of their choice and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Jace, Wielder of Mysteries

If you would draw a card while your library has no cards in it, you win the game instead.
+1: Target player mills two cards. Draw a card.
−8: Draw seven cards. Then if your library has no cards in it, you win the game.

Back to Basics

Nonbasic lands don't untap during their controllers' untap steps.

Archfiend of Depravity

Flying
At the beginning of each opponent's end step, that player chooses up to two creatures they control, then sacrifices the rest.

The Haunt of Hightower

Flying, lifelink
Whenever The Haunt of Hightower attacks, defending player discards a card.
Whenever a card is put into an opponent's graveyard from anywhere, put a +1/+1 counter on The Haunt of Hightower.

Mesmeric Orb

Whenever a permanent becomes untapped, that permanent's controller mills a card.

Nissa of Shadowed Boughs

Landfall — Whenever a land you control enters, put a loyalty counter on Nissa of Shadowed Boughs.
+1: Untap target land you control. You may have it become a 3/3 Elemental creature with haste and menace until end of turn. It's still a land.
−5: You may put a creature card with mana value less than or equal to the number of lands you control onto the battlefield from your hand or graveyard with two +1/+1 counters on it.

Vraska, Golgari Queen

+2: You may sacrifice another permanent. If you do, you gain 1 life and draw a card.
−3: Destroy target nonland permanent with mana value 3 or less.
−9: You get an emblem with "Whenever a creature you control deals combat damage to a player, that player loses the game."

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