Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Gix, Yawgmoth Praetor

Whenever a creature deals combat damage to one of your opponents, its controller may pay 1 life. If they do, they draw a card.
{4}{B}{B}{B}, Discard X cards: Exile the top X cards of target opponent's library. You may play lands and cast spells from among cards exiled this way without paying their mana costs.

Megrim

Whenever an opponent discards a card, Megrim deals 2 damage to that player.

Oppression

Whenever a player casts a spell, that player discards a card.

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