Contagion Engine

When Contagion Engine enters, put a -1/-1 counter on each creature target player controls.
{4}, {T}: Proliferate twice. (Choose any number of permanents and/or players, then give each another counter of each kind already there. Then do it again.)

Vandalblast

Destroy target artifact you don't control.
Overload {4}{R} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Settle the Wreckage

Exile all attacking creatures target player controls. That player may search their library for that many basic land cards, put those cards onto the battlefield tapped, then shuffle.

Make an Example

Each opponent separates the creatures they control into two piles. For each opponent, you choose one of their piles. Each opponent sacrifices the creatures in their chosen pile. (Piles can be empty.)

Nightmare Unmaking

Choose one —
• Exile each creature with power greater than the number of cards in your hand.
• Exile each creature with power less than the number of cards in your hand.

Orcus, Prince of Undeath

Flying, trample
When Orcus, Prince of Undeath enters, choose one —
• Each other creature gets -X/-X until end of turn. You lose X life.
• Return up to X target creature cards with total mana value X or less from your graveyard to the battlefield. They gain haste until end of turn.

Perplexing Test

Choose one —
• Return all creature tokens to their owners' hands.
• Return all nontoken creatures to their owners' hands.

Last One Standing

Choose a creature at random, then destroy the rest.

Ajani Vengeant

+1: Target permanent doesn't untap during its controller's next untap step.
−2: Ajani Vengeant deals 3 damage to any target and you gain 3 life.
−7: Destroy all lands target player controls.

Amalia Benavides Aguirre

Ward—Pay 3 life.
Whenever you gain life, Amalia Benavides Aguirre explores. Then destroy all other creatures if its power is exactly 20. (To have this creature explore, reveal the top card of your library. Put that card into your hand if it's a land. Otherwise, put a +1/+1 counter on this creature, then put the card back or put it into your graveyard.)

Anarchy

Angrath, Minotaur Pirate

+2: Angrath, Minotaur Pirate deals 1 damage to target opponent or planeswalker and each creature that player or that planeswalker's controller controls.
−3: Return target Pirate card from your graveyard to the battlefield.
−11: Destroy all creatures target opponent controls. Angrath, Minotaur Pirate deals damage to that player equal to their total power.

Anzrag's Rampage

Destroy all artifacts you don't control, then exile the top X cards of your library, where X is the number of artifacts that were put into graveyards from the battlefield this turn. You may put a creature card exiled this way onto the battlefield. It gains haste. Return it to your hand at the beginning of the next end step.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Blood on the Snow

Choose one —
• Destroy all creatures.
• Destroy all planeswalkers.
Then return a creature or planeswalker card with mana value X or less from your graveyard to the battlefield, where X is the amount of {S} spent to cast this spell. ({S} is mana from a snow source.)

Brotherhood's End

Choose one —
• Brotherhood's End deals 3 damage to each creature and each planeswalker.
• Destroy all artifacts with mana value 3 or less.

Cacophony Unleashed

When Cacophony Unleashed enters, if you cast it, destroy all nonenchantment creatures.
Whenever Cacophony Unleashed or another enchantment you control enters, until end of turn, Cacophony Unleashed becomes a legendary 6/6 Nightmare God creature with menace and deathtouch. It's still an enchantment.

Calming Verse

Destroy all enchantments you don't control. Then if you control an untapped land, destroy all enchantments you control.

Celestial Kirin

Flying
Whenever you cast a Spirit or Arcane spell, destroy all permanents with that spell's mana value.

Citywide Bust

Destroy all creatures with toughness 4 or greater.

Cleansing Meditation

Destroy all enchantments.
Threshold — If seven or more cards are in your graveyard, instead destroy all enchantments, then return all cards in your graveyard destroyed this way to the battlefield.

Crisis of Conscience

Choose one —
• Destroy all tokens.
• Destroy all nonland, nontoken permanents.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Damning Verdict

Destroy all creatures with no counters on them.

Deathbringer Regent

Flying
When Deathbringer Regent enters, if you cast it from your hand and there are five or more other creatures on the battlefield, destroy all other creatures.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Desolation Giant

Kicker {W}{W} (You may pay an additional {W}{W} as you cast this spell.)
When Desolation Giant enters, destroy all other creatures you control. If it was kicked, destroy all other creatures instead.

Don't Move

Destroy all tapped creatures. Until your next turn, whenever a creature becomes tapped, destroy it.

Dread Cacodemon

When Dread Cacodemon enters, if you cast it from your hand, destroy all creatures your opponents control, then tap all other creatures you control.

Dusk

Destroy all creatures with power 3 or greater.

Dawn

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Return all creature cards with power 2 or less from your graveyard to your hand.

Dusk // Dawn

Elesh Norn

Vigilance
Whenever a source an opponent controls deals damage to you or a permanent you control, that source's controller loses 2 life unless they pay {1}.
{2}{W}, Sacrifice three other creatures: Exile Elesh Norn, then return it to the battlefield transformed under its owner's control. Activate only as a sorcery.

The Argent Etchings

(As this Saga enters and after your draw step, add a lore counter.)
I — Incubate 2 five times, then transform all Incubator tokens you control.
II — Creatures you control get +1/+1 and gain double strike until end of turn.
III — Destroy all other permanents except for artifacts, lands, and Phyrexians. Exile The Argent Etchings, then return it to the battlefield (front face up).

Elesh Norn // The Argent Etchings

Elspeth, Sun's Champion

+1: Create three 1/1 white Soldier creature tokens.
−3: Destroy all creatures with power 4 or greater.
−7: You get an emblem with "Creatures you control get +2/+2 and have flying."

Elspeth Tirel

+2: You gain 1 life for each creature you control.
−2: Create three 1/1 white Soldier creature tokens.
−5: Destroy all other permanents except for lands and tokens.

Endemic Plague

As an additional cost to cast this spell, sacrifice a creature.
Destroy all creatures that share a creature type with the sacrificed creature. They can't be regenerated.

Essence Filter

Destroy all enchantments or all nonwhite enchantments.

Expel the Interlopers

Choose a number between 0 and 10. Destroy all creatures with power greater than or equal to the chosen number.

Exterminatus

Nonland permanents your opponents control lose indestructible until end of turn.
Destroy all nonland permanents.

Extinction

Destroy all creatures of the creature type of your choice.

Extinguish All Hope

Fell the Mighty

Destroy all creatures with power greater than target creature's power.

Final Showdown

Spree (Choose one or more additional costs.)
+ {1} — All creatures lose all abilities until end of turn.
+ {1} — Choose a creature you control. It gains indestructible until end of turn.
+ {3}{W}{W} — Destroy all creatures.

Forced March

Destroy all creatures with mana value X or less.

Fortunate Few

Choose a nonland permanent you don't control, then each other player chooses a nonland permanent they don't control that hasn't been chosen this way. Destroy all other nonland permanents.

Genesis of the Daleks

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after IV.)
I, II, III — Create a 3/3 black Dalek artifact creature token with menace for each lore counter on Genesis of the Daleks.
IV — Target opponent faces a villainous choice — Destroy all Dalek creatures and each of your opponents loses life equal to the total power of Daleks that died this turn, or destroy all non-Dalek creatures.

Grim Giganotosaurus

{10}{B}{G}: Monstrosity 10. This ability costs {1} less to activate for each creature with power 4 or greater your opponents control. (If this creature isn't monstrous, put ten +1/+1 counters on it and it becomes monstrous.)
When Grim Giganotosaurus becomes monstrous, destroy all artifacts and creatures other than Grim Giganotosaurus.

Guan Yu's 1,000-Li March

Hammer Mage

{X}{R}, {T}, Discard a card: Destroy all artifacts with mana value X or less.

Harsh Mercy

Each player chooses a creature type. Destroy all creatures that aren't of a type chosen this way. They can't be regenerated.

Hellfire

Destroy all nonblack creatures. Hellfire deals X plus 3 damage to you, where X is the number of creatures that died this way.

Hythonia the Cruel

Deathtouch
{6}{B}{B}: Monstrosity 3. (If this creature isn't monstrous, put three +1/+1 counters on it and it becomes monstrous.)
When Hythonia the Cruel becomes monstrous, destroy all non-Gorgon creatures.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Invasion of Fiora

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Fiora enters, choose one or both —
• Destroy all legendary creatures.
• Destroy all nonlegendary creatures.

Marchesa, Resolute Monarch

Menace, deathtouch
Whenever Marchesa, Resolute Monarch attacks, remove all counters from up to one target permanent.
At the beginning of your upkeep, if you haven't been dealt combat damage since your last turn, you draw a card and you lose 1 life.

Invasion of Fiora // Marchesa, Resolute Monarch

Kindred Dominance

Choose a creature type. Destroy all creatures that aren't of the chosen type.

Liliana, Death's Majesty

+1: Create a 2/2 black Zombie creature token. Mill two cards.
−3: Return target creature card from your graveyard to the battlefield. That creature is a black Zombie in addition to its other colors and types.
−7: Destroy all non-Zombie creatures.

Localized Destruction

You get {E} (an energy counter), then you may pay one or more {E}. If you do, each creature you control with power equal to the amount of {E} paid this way gains indestructible until end of turn.
Destroy all creatures.

Mageta the Lion

{2}{W}{W}, {T}, Discard two cards: Destroy all creatures except for Mageta the Lion. Those creatures can't be regenerated.

Magister of Worth

Flying
Will of the council — When Magister of Worth enters, starting with you, each player votes for grace or condemnation. If grace gets more votes, each player returns each creature card from their graveyard to the battlefield. If condemnation gets more votes or the vote is tied, destroy all creatures other than Magister of Worth.

Mandate of Abaddon

Choose target creature you control. Destroy all creatures with power less than that creature's power.

Martial Coup

Create X 1/1 white Soldier creature tokens. If X is 5 or more, destroy all other creatures.

Mass Calcify

Mogg Infestation

Destroy all creatures target player controls. For each creature that died this way, that player creates two 1/1 red Goblin creature tokens.

Myojin of Cleansing Fire

Myojin of Cleansing Fire enters with a divinity counter on it if you cast it from your hand.
Myojin of Cleansing Fire has indestructible as long as it has a divinity counter on it.
Remove a divinity counter from Myojin of Cleansing Fire: Destroy all other creatures.

Nature's Ruin

Necromantic Selection

Destroy all creatures, then return a creature card put into a graveyard this way to the battlefield under your control. It's a black Zombie in addition to its other colors and types. Exile Necromantic Selection.

Novablast Wurm

Whenever Novablast Wurm attacks, destroy all other creatures.

One Ring to Rule Them All

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — The Ring tempts you, then each player mills cards equal to your Ring-bearer's power.
II — Destroy all nonlegendary creatures.
III — Each opponent loses 1 life for each creature card in that player's graveyard.

Organic Extinction

Improvise (Your artifacts can help cast this spell. Each artifact you tap after you're done activating mana abilities pays for {1}.)
Destroy all nonartifact creatures.

Paraselene

Destroy all enchantments. You gain 1 life for each enchantment destroyed this way.

Path of Peril

Cleave {4}{W}{B} (You may cast this spell for its cleave cost. If you do, remove the words in square brackets.)
Destroy all creatures [with mana value 2 or less].

Perish

Destroy all green creatures. They can't be regenerated.

Pest Control

Destroy all nonland permanents with mana value 1 or less.
Cycling {2} ({2}, Discard this card: Draw a card.)

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Phyrexian Scriptures

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Put a +1/+1 counter on up to one target creature. That creature becomes an artifact in addition to its other types.
II — Destroy all nonartifact creatures.
III — Exile all opponents' graveyards.

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Primeval Light

Destroy all enchantments target player controls.

Puppet's Verdict

Flip a coin. If you win the flip, destroy all creatures with power 2 or less. If you lose the flip, destroy all creatures with power 3 or greater.

Rain of Daggers

Destroy all creatures target opponent controls. You lose 2 life for each creature destroyed this way.

Realm-Cloaked Giant

Cast Off

Destroy all non-Giant creatures. (Then exile this card. You may cast the creature later from exile.)

Realm-Cloaked Giant // Cast Off

Reign of Terror

Destroy all green creatures or all white creatures. They can't be regenerated. You lose 2 life for each creature that died this way.

Reiver Demon

Flying
When Reiver Demon enters, if you cast it from your hand, destroy all nonartifact, nonblack creatures. They can't be regenerated.

Overwhelming Forces

Destroy all creatures target opponent controls. Draw a card for each creature destroyed this way.

Remove Enchantments

Return to your hand all enchantments you both own and control, all Auras you own attached to permanents you control, and all Auras you own attached to attacking creatures your opponents control. Then destroy all other enchantments you control, all other Auras attached to permanents you control, and all other Auras attached to attacking creatures your opponents control.

Retaliate

Destroy all creatures that dealt damage to you this turn.

Retribution of the Meek

Destroy all creatures with power 4 or greater. They can't be regenerated.

Ritual of Soot

Destroy all creatures with mana value 3 or less.

Root Greevil

{2}{G}, {T}, Sacrifice Root Greevil: Destroy all enchantments of the color of your choice.

Ruination

Ruinous Ultimatum

Destroy all nonland permanents your opponents control.

Scourglass

{T}, Sacrifice Scourglass: Destroy all permanents except for artifacts and lands. Activate only during your upkeep.

Season of the Witch

At the beginning of your upkeep, sacrifice Season of the Witch unless you pay 2 life.
At the beginning of the end step, destroy all untapped creatures that didn't attack this turn, except for creatures that couldn't attack.

Selfless Glyphweaver

Exile Selfless Glyphweaver: Creatures you control gain indestructible until end of turn.

Deadly Vanity

Choose a creature or planeswalker, then destroy all other creatures and planeswalkers.

Selfless Glyphweaver // Deadly Vanity

Sivitri, Dragon Master

+1: Until your next turn, creatures can't attack you or planeswalkers you control unless their controller pays 2 life for each of those creatures.
−3: Search your library for a Dragon card, reveal it, put it into your hand, then shuffle.
−7: Destroy all non-Dragon creatures.
Sivitri, Dragon Master can be your commander.

Slash the Ranks

Destroy all creatures and planeswalkers except for commanders.

Solar Tide

Choose one —
• Destroy all creatures with power 2 or less.
• Destroy all creatures with power 3 or greater.
Entwine—Sacrifice two lands. (Choose both if you pay the entwine cost.)

Soulscour

Spreading Plague

Whenever a creature enters, destroy all other creatures that share a color with it. They can't be regenerated.

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