Izoni, Center of the Web

Menace
Whenever Izoni, Center of the Web enters or attacks, you may collect evidence 4. If you do, create two 2/1 black and green Spider creature tokens with menace and reach.
Sacrifice four tokens: Surveil 2, then draw two cards. You gain 2 life.

Brood Weaver

Reach
When Brood Weaver dies, create a 1/2 green Spider creature token with reach.

Drider

Reach
Whenever Drider deals combat damage to a player, create a 2/1 black Spider creature token with menace and reach.

Twin-Silk Spider

Reach
When Twin-Silk Spider enters, create a 1/2 green Spider creature token with reach.

Copper Longlegs

Reach
{1}{G}, Sacrifice Copper Longlegs: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Fynn, the Fangbearer

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Whenever a creature you control with deathtouch deals combat damage to a player, that player gets two poison counters. (A player with ten or more poison counters loses the game.)

Arachnus Web

Enchant creature
Enchanted creature can't attack or block, and its activated abilities can't be activated.
At the beginning of the end step, if enchanted creature's power is 4 or greater, destroy Arachnus Web.

Ishkanah, Grafwidow

Reach
Delirium — When Ishkanah, Grafwidow enters, if there are four or more card types among cards in your graveyard, create three 1/2 green Spider creature tokens with reach.
{6}{B}: Target opponent loses 1 life for each Spider you control.

Chainweb Aracnir

Reach
When Chainweb Aracnir enters, it deals damage equal to its power to target creature with flying an opponent controls.
Escape—{3}{G}{G}, Exile four other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)
Chainweb Aracnir escapes with three +1/+1 counters on it.

Drown in Ichor

Target creature gets -4/-4 until end of turn. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Arachnogenesis

Create X 1/2 green Spider creature tokens with reach, where X is the number of creatures attacking you. Prevent all combat damage that would be dealt this turn by non-Spider creatures.

Deadly Recluse

Reach (This creature can block creatures with flying.)
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)

Thirsting Roots

Choose one —
• Search your library for a basic land card, reveal it, put it into your hand, then shuffle.
• Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Curse of Clinging Webs

Enchant player
Whenever a nontoken creature enchanted player controls dies, exile it and you create a 1/2 green Spider creature token with reach.

Venerated Rotpriest

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Whenever a creature you control becomes the target of a spell, target opponent gets a poison counter.

Cankerbloom

{1}, Sacrifice Cankerbloom: Choose one —
• Destroy target artifact.
• Destroy target enchantment.
• Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Infectious Bite

Target creature you control deals damage equal to its power to target creature you don't control. Each opponent gets a poison counter.

Ruins Recluse

Reach, deathtouch
{3}{G}: Put a +1/+1 counter on Ruins Recluse.

Vraska's Fall

Each opponent sacrifices a creature or planeswalker of their choice and gets a poison counter.

Lolth, Spider Queen

Whenever a creature you control dies, put a loyalty counter on Lolth, Spider Queen.
0: You draw a card and you lose 1 life.
−3: Create two 2/1 black Spider creature tokens with menace and reach.
−8: You get an emblem with "Whenever an opponent is dealt combat damage by one or more creatures you control, if that player lost less than 8 life this turn, they lose life equal to the difference."

Mirkwood Spider

Deathtouch
Whenever Mirkwood Spider attacks, target legendary creature you control gains deathtouch until end of turn.

Shelob, Dread Weaver

Whenever a nontoken creature an opponent controls dies, exile it.
{2}{B}, Put a creature card exiled with Shelob, Dread Weaver into its owner's graveyard: Put two +1/+1 counters on Shelob. Draw a card.
{X}{1}{B}: Put target creature card with mana value X exiled with Shelob onto the battlefield tapped under your control.

Broodspinner

Reach
When Broodspinner enters, surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)
{4}{B}{G}, {T}, Sacrifice Broodspinner: Create a number of 1/1 black and green Insect creature tokens with flying equal to the number of card types among cards in your graveyard.

Grafted Exoskeleton

Equipped creature gets +2/+2 and has infect. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Whenever Grafted Exoskeleton becomes unattached from a permanent, sacrifice that permanent.
Equip {2}

The Swarmweaver

When The Swarmweaver enters, create two 1/1 black and green Insect creature tokens with flying.
Delirium — As long as there are four or more card types among cards in your graveyard, Insects and Spiders you control get +1/+1 and have deathtouch.

Relic Putrescence

Enchant artifact
Whenever enchanted artifact becomes tapped, its controller gets a poison counter.

Aveline de Grandpré

Deathtouch
Whenever a creature you control with deathtouch deals combat damage to a player, put that many +1/+1 counters on that creature.
Disguise {B}{G} (You may cast this card face down for {3} as a 2/2 creature with ward {2}. Turn it face up any time for its disguise cost.)

Phyresis

Enchant creature
Enchanted creature has infect. (It deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Atomize

Destroy target nonland permanent. Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Sweet-Gum Recluse

Flash
Cascade
Reach
When Sweet-Gum Recluse enters, put three +1/+1 counters on each of any number of target creatures that entered this turn.

Watcher in the Web

Reach (This creature can block creatures with flying.)
Watcher in the Web can block an additional seven creatures each combat.

Penumbra Spider

Reach
When Penumbra Spider dies, create a 2/4 black Spider creature token with reach.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature of their choice.
• Each opponent sacrifices a creature token of their choice.
• Each opponent sacrifices a planeswalker of their choice.

Obelisk Spider

Reach
Whenever Obelisk Spider deals combat damage to a creature, put a -1/-1 counter on that creature.
Whenever you put one or more -1/-1 counters on a creature, each opponent loses 1 life and you gain 1 life.

Cultivate

Search your library for up to two basic land cards, reveal those cards, put one onto the battlefield tapped and the other into your hand, then shuffle.

Shelob, Child of Ungoliant

Deathtouch, ward {2}
Other Spiders you control have deathtouch and ward {2}.
Whenever another creature dealt damage this turn by a Spider you controlled dies, create a token that's a copy of that creature, except it's a Food artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life," and it loses all other card types.

Twitching Doll

{T}: Add one mana of any color. Put a nest counter on Twitching Doll.
{T}, Sacrifice Twitching Doll: Create a 2/2 green Spider creature token with reach for each counter on Twitching Doll. Activate only as a sorcery.

Prosthetic Injector

Equipped creature gets +0/+2 and has toxic 1. (Players dealt combat damage by equipped creature also get a poison counter.)
Equip {1}

Blightwidow

Reach (This creature can block creatures with flying.)
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Silklash Spider

Reach
{X}{G}{G}: Silklash Spider deals X damage to each creature with flying.

Roar of Challenge

All creatures able to block target creature this turn do so.
Ferocious — That creature gains indestructible until end of turn if you control a creature with power 4 or greater.

Glint Weaver

Reach
When Glint Weaver enters, distribute three +1/+1 counters among one, two, or three target creatures, then you gain life equal to the greatest toughness among creatures you control.

Noxious Assault

Creatures you control get +2/+2 until end of turn. Whenever a creature blocks this turn, its controller gets a poison counter.

Skyfisher Spider

Reach
When Skyfisher Spider enters, you may sacrifice another creature. When you do, destroy target nonland permanent.
When Skyfisher Spider dies, you may gain 1 life for each creature card in your graveyard. If you do, exile Skyfisher Spider from your graveyard.

Rotwidow Pack

Reach
{3}{B}{G}, Exile a creature card from your graveyard: Create a 1/2 green Spider creature token with reach, then each opponent loses 1 life for each Spider you control.

Arasta of the Endless Web

Reach
Whenever an opponent casts an instant or sorcery spell, create a 1/2 green Spider creature token with reach.

Infectious Inquiry

You draw two cards and you lose 2 life. Each opponent gets a poison counter.

Spider Spawning

Create a 1/2 green Spider creature token with reach for each creature card in your graveyard.
Flashback {6}{B} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Throne of Geth

{T}, Sacrifice an artifact: Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Arachnus Spinner

Reach
Tap an untapped Spider you control: Search your graveyard and/or library for a card named Arachnus Web and put it onto the battlefield attached to target creature. If you search your library this way, shuffle.

Decimator Web

{4}, {T}: Target opponent loses 2 life, gets a poison counter, then mills six cards.

Smell Fear

Proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)
Target creature you control fights up to one target creature you don't control.

Doom Weaver

Reach
Soulbond (You may pair this creature with another unpaired creature when either enters. They remain paired for as long as you control both of them.)
As long as Doom Weaver is paired with another creature, each of those creatures has "When this creature dies, draw cards equal to its power."