Go for the Throat

Creeping Dread

At the beginning of your upkeep, each player discards a card. Each opponent who discarded a card that shares a card type with the card you discarded loses 3 life. (Players reveal the discarded cards simultaneously.)

Spreading Plague

Whenever a creature enters, destroy all other creatures that share a color with it. They can't be regenerated.

Ankh of Mishra

Whenever a land enters, Ankh of Mishra deals 2 damage to that land's controller.

Aether Flash

Whenever a creature enters, Aether Flash deals 2 damage to it.

Last One Standing

Choose a creature at random, then destroy the rest.

Firemind Vessel

Firemind Vessel enters tapped.
{T}: Add two mana of different colors.

Sulfuric Vortex

At the beginning of each player's upkeep, Sulfuric Vortex deals 2 damage to that player.
If a player would gain life, that player gains no life instead.

Vandalblast

Destroy target artifact you don't control.
Overload {4}{R} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Rampaging Ferocidon

Menace
Players can't gain life.
Whenever another creature enters, Rampaging Ferocidon deals 1 damage to that creature's controller.

Scrambleverse

For each nonland permanent, choose a player at random. Then each player gains control of each permanent for which they were chosen. Untap those permanents.

Archfiend of Depravity

Flying
At the beginning of each opponent's end step, that player chooses up to two creatures they control, then sacrifices the rest.

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Slagstorm

Choose one —
• Slagstorm deals 3 damage to each creature.
• Slagstorm deals 3 damage to each player.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Manabarbs

Whenever a player taps a land for mana, Manabarbs deals 1 damage to that player.

Rakdos Signet

Aurora of Emrakul

Flying, deathtouch
Whenever Aurora of Emrakul attacks, each opponent loses 3 life.

Cryptolith Fragment

Cryptolith Fragment enters tapped.
{T}: Add one mana of any color. Each player loses 1 life.
At the beginning of your upkeep, if each player has 10 or less life, transform Cryptolith Fragment.

Cryptolith Fragment // Aurora of Emrakul

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Darksteel Ingot

Indestructible (Effects that say "destroy" don't destroy this artifact.)
{T}: Add one mana of any color.

Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Lethal Vapors

Whenever a creature enters, destroy it.
{0}: Destroy Lethal Vapors. You skip your next turn. Any player may activate this ability.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters, each player loses a third of their life, rounded up.

Sol Ring

Thermo-Alchemist

Defender
{T}: Thermo-Alchemist deals 1 damage to each opponent.
Whenever you cast an instant or sorcery spell, untap Thermo-Alchemist.

Rain of Gore

If a spell or ability would cause its controller to gain life, that player loses that much life instead.

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Chromatic Lantern

Lands you control have "{T}: Add one mana of any color."
{T}: Add one mana of any color.

Angrath, the Flame-Chained

+1: Each opponent discards a card and loses 2 life.
−3: Gain control of target creature until end of turn. Untap it. It gains haste until end of turn. Sacrifice it at the beginning of the next end step if it has mana value 3 or less.
−8: Each opponent loses life equal to the number of cards in their graveyard.

Warp World

Each player shuffles all permanents they own into their library, then reveals that many cards from the top of their library. Each player puts all artifact, creature, and land cards revealed this way onto the battlefield, then does the same for enchantment cards, then puts all cards revealed this way that weren't put onto the battlefield on the bottom of their library.

Spiteful Visions

At the beginning of each player's draw step, that player draws an additional card.
Whenever a player draws a card, Spiteful Visions deals 1 damage to that player.

Furnace of Rath

If a source would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Massacre Wurm

When this creature enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Underworld Connections

Enchant land
Enchanted land has "{T}, Pay 1 life: Draw a card."

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Fanatic of Mogis

When Fanatic of Mogis enters, it deals damage to each opponent equal to your devotion to red. (Each {R} in the mana costs of permanents you control counts toward your devotion to red.)

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Rakdos Guildgate

This land enters tapped.
{T}: Add {B} or {R}.

Dictate of the Twin Gods

Flash
If a source would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Temple of Malice

This land enters tapped.
When this land enters, scry 1. (Look at the top card of your library. You may put that card on the bottom.)
{T}: Add {B} or {R}.

Grim Guardian

Constellation — Whenever Grim Guardian or another enchantment you control enters, each opponent loses 1 life.

Rakdos Charm

Choose one —
• Exile target player's graveyard.
• Destroy target artifact.
• Each creature deals 1 damage to its controller.

Tresserhorn Sinks

Tresserhorn Sinks enters tapped.
{T}: Add {B} or {R}.

Kuon's Essence

At the beginning of each player's upkeep, that player sacrifices a creature of their choice.

Kuon, Ogre Ascendant

At the beginning of the end step, if three or more creatures died this turn, flip Kuon, Ogre Ascendant.

Kuon, Ogre Ascendant // Kuon's Essence

Planar Void

Whenever another card is put into a graveyard from anywhere, exile that card.

Bedevil

Destroy target artifact, creature, or planeswalker.

Bloodfell Caves

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {B} or {R}.

Crypt Rats

{X}: Crypt Rats deals X damage to each creature and each player. Spend only black mana on X.

Spellshock

Whenever a player casts a spell, Spellshock deals 2 damage to that player.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Vicious Shadows

Whenever a creature dies, you may have Vicious Shadows deal damage to target player equal to the number of cards in that player's hand.

Painful Lesson

Target player draws two cards and loses 2 life.

Terminate

Destroy target creature. It can't be regenerated.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Revel in Riches

Whenever a creature an opponent controls dies, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")
At the beginning of your upkeep, if you control ten or more Treasures, you win the game.

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Massacre Girl

Menace
When Massacre Girl enters, each other creature gets -1/-1 until end of turn. Whenever a creature dies this turn, each creature other than Massacre Girl gets -1/-1 until end of turn.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

Mogis, God of Slaughter

Indestructible
As long as your devotion to black and red is less than seven, Mogis isn't a creature.
At the beginning of each opponent's upkeep, Mogis deals 2 damage to that player unless they sacrifice a creature of their choice.

Murder

Ribbons

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Each opponent loses X life.

Cut // Ribbons

Mountain

Swamp

Languish

All creatures get -4/-4 until end of turn.

Sunbird's Invocation

Whenever you cast a spell from your hand, reveal the top X cards of your library, where X is that spell's mana value. You may cast a spell with mana value X or less from among cards revealed this way without paying its mana cost. Put the rest on the bottom of your library in a random order.

Brimstone Trebuchet

Defender, reach
{T}: Brimstone Trebuchet deals 1 damage to each opponent.
Whenever a Knight you control enters, untap Brimstone Trebuchet.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Pyrostatic Pillar

Whenever a player casts a spell with mana value 3 or less, Pyrostatic Pillar deals 2 damage to that player.