Descent into Madness

At the beginning of your upkeep, put a despair counter on Descent into Madness, then each player exiles X permanents they control and/or cards from their hand, where X is the number of despair counters on Descent into Madness.

Asylum Visitor

At the beginning of each player's upkeep, if that player has no cards in hand, you draw a card and you lose 1 life.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Throne of Death

At the beginning of your upkeep, mill a card.
{2}{B}, {T}, Exile a creature card from your graveyard: Draw a card.

Egon, God of Death

Deathtouch
At the beginning of your upkeep, exile two cards from your graveyard. If you can't, sacrifice Egon and draw a card.

Egon, God of Death // Throne of Death

Persist

Return target nonlegendary creature card from your graveyard to the battlefield with a -1/-1 counter on it.

Oppression

Whenever a player casts a spell, that player discards a card.

Tasigur's Cruelty

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
Each opponent discards two cards.

Storage Matrix

As long as Storage Matrix is untapped, each player chooses artifact, creature, or land during their untap step. That player can untap only permanents of the chosen type this step.

Static Orb

As long as Static Orb is untapped, players can't untap more than two permanents during their untap steps.

Ripples of Undeath

At the beginning of your first main phase, mill three cards. Then you may pay {1} and 3 life. If you do, put a card from among those cards into your hand.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Sol Ring

Null Brooch

{2}, {T}, Discard your hand: Counter target noncreature spell.

Overlord of the Balemurk

Impending 5—{1}{B} (If you cast this spell for its impending cost, it enters with five time counters and isn't a creature until the last is removed. At the beginning of your end step, remove a time counter from it.)
Whenever Overlord of the Balemurk enters or attacks, mill four cards, then you may return a non-Avatar creature card or a planeswalker card from your graveyard to your hand.

Desolation

At the beginning of each end step, each player who tapped a land for mana this turn sacrifices a land of their choice. Desolation deals 2 damage to each player who sacrificed a Plains this way.

Chain of Smog

Target player discards two cards. That player may copy this spell and may choose a new target for that copy.

Tangle Wire

Fading 4 (This artifact enters with four fade counters on it. At the beginning of your upkeep, remove a fade counter from it. If you can't, sacrifice it.)
At the beginning of each player's upkeep, that player taps an untapped artifact, creature, or land they control for each fade counter on Tangle Wire.

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Unearth

Return target creature card with mana value 3 or less from your graveyard to the battlefield.
Cycling {2} ({2}, Discard this card: Draw a card.)

Smokestack

At the beginning of your upkeep, you may put a soot counter on Smokestack.
At the beginning of each player's upkeep, that player sacrifices a permanent of their choice for each soot counter on Smokestack.

Virus Beetle

When Virus Beetle enters, each opponent discards a card.

Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control of their choice, then sacrifices a third of the lands they control of their choice. Round up each time.

Victimize

Choose two target creature cards in your graveyard. Sacrifice a creature. If you do, return the chosen cards to the battlefield tapped.

Smallpox

Each player loses 1 life, discards a card, sacrifices a creature of their choice, then sacrifices a land of their choice.

Delirium Skeins

Bitterblossom

At the beginning of your upkeep, you lose 1 life and create a 1/1 black Faerie Rogue creature token with flying.

Darkstar Augur

Offspring {B} (You may pay an additional {B} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Flying
At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Winter Orb

As long as Winter Orb is untapped, players can't untap more than one land during their untap steps.

Necrogoyf

Necrogoyf's power is equal to the number of creature cards in all graveyards.
At the beginning of each player's upkeep, that player discards a card.
Madness {1}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Possessed Portal

If a player would draw a card, that player skips that draw instead.
At the beginning of each end step, each player sacrifices a permanent of their choice unless they discard a card.

Null Elemental Blast

Choose one —
• Counter target multicolored spell.
• Destroy target multicolored permanent.

Solemn Simulacrum

When this creature enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When this creature dies, you may draw a card.

Contamination

At the beginning of your upkeep, sacrifice Contamination unless you sacrifice a creature.
If a land is tapped for mana, it produces {B} instead of any other type and amount.

Bottomless Pit

At the beginning of each player's upkeep, that player discards a card at random.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.