Sire of Insanity

At the beginning of each end step, each player discards their hand.

Orcus, Prince of Undeath

Flying, trample
When Orcus, Prince of Undeath enters, choose one —
• Each other creature gets -X/-X until end of turn. You lose X life.
• Return up to X target creature cards with total mana value X or less from your graveyard to the battlefield. They gain haste until end of turn.

Knollspine Dragon

Flying
When Knollspine Dragon enters, you may discard your hand and draw cards equal to the damage dealt to target opponent this turn.

Sower of Discord

Flying
As Sower of Discord enters, choose two players.
Whenever damage is dealt to one of the chosen players, the other chosen player also loses that much life.

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature of their choice and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Rune-Scarred Demon

Flying
When this creature enters, search your library for a card, put it into your hand, then shuffle.

Meteor Golem

When this creature enters, destroy target nonland permanent an opponent controls.

Harvester of Souls

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Whenever another nontoken creature dies, you may draw a card.

Rakdos, the Showstopper

Flying, trample
When Rakdos, the Showstopper enters, flip a coin for each creature that isn't a Demon, Devil, or Imp. Destroy each creature whose coin comes up tails.

Indulgent Tormentor

Flying
At the beginning of your upkeep, draw a card unless target opponent sacrifices a creature of their choice or pays 3 life.

Bloodthirster

Flying, trample
Whenever Bloodthirster deals combat damage to a player, untap it. After this phase, there is an additional combat phase.
Bloodthirster can't attack a player it has already attacked this turn.

Rakdos Joins Up

When Rakdos Joins Up enters, return target creature card from your graveyard to the battlefield with two additional +1/+1 counters on it.
Whenever a legendary creature you control dies, Rakdos Joins Up deals damage equal to that creature's power to target opponent.

Kozilek, the Great Distortion

When you cast this spell, if you have fewer than seven cards in hand, draw cards equal to the difference.
Menace
Discard a card with mana value X: Counter target spell with mana value X.

Sandstone Oracle

Flying
When Sandstone Oracle enters, choose an opponent. If that player has more cards in hand than you, draw cards equal to the difference.

It That Betrays

Annihilator 2 (Whenever this creature attacks, defending player sacrifices two permanents of their choice.)
Whenever an opponent sacrifices a nontoken permanent, put that card onto the battlefield under your control.

Herald of Slaanesh

Locus of Slaanesh — Demon spells you cast cost {2} less to cast.
Other Demons you control have haste.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Spear Spewer

Defender
{T}: Spear Spewer deals 1 damage to each player.

Walking Ballista

Walking Ballista enters with X +1/+1 counters on it.
{4}: Put a +1/+1 counter on Walking Ballista.
Remove a +1/+1 counter from Walking Ballista: It deals 1 damage to any target.

Dread Cacodemon

When Dread Cacodemon enters, if you cast it from your hand, destroy all creatures your opponents control, then tap all other creatures you control.

Ulamog's Crusher

Annihilator 2 (Whenever this creature attacks, defending player sacrifices two permanents of their choice.)
Ulamog's Crusher attacks each combat if able.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Raphael, Fiendish Savior

Flying
Other Demons, Devils, Imps, and Tieflings you control get +1/+1 and have lifelink.
At the beginning of each end step, if a creature card was put into your graveyard from anywhere this turn, create a 1/1 red Devil creature token with "When this creature dies, it deals 1 damage to any target."

Ancient Cellarspawn

Each spell you cast that's a Demon, Horror, or Nightmare costs {1} less to cast.
Whenever you cast a spell, if the amount of mana spent to cast it was less than its mana value, target opponent loses life equal to the difference.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Unlicensed Disintegration

Destroy target creature. If you control an artifact, Unlicensed Disintegration deals 3 damage to that creature's controller.

Anger

Haste
As long as Anger is in your graveyard and you control a Mountain, creatures you control have haste.

Infernal Sovereign

Flying, trample
Skip your draw step.
Whenever you play a land or cast a spell, you draw a card and you lose 1 life.

Rakdos, Lord of Riots

You can't cast Rakdos, Lord of Riots unless an opponent lost life this turn.
Flying, trample
Creature spells you cast cost {1} less to cast for each 1 life your opponents have lost this turn.

Burning-Rune Demon

Flying
When Burning-Rune Demon enters, you may search your library for exactly two cards not named Burning-Rune Demon that have different names. If you do, reveal those cards. An opponent chooses one of them. Put the chosen card into your hand and the other into your graveyard, then shuffle.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Pathrazer of Ulamog

Annihilator 3 (Whenever this creature attacks, defending player sacrifices three permanents of their choice.)
Pathrazer of Ulamog can't be blocked except by three or more creatures.

Heartless Hidetsugu

{T}: Heartless Hidetsugu deals damage to each player equal to half that player's life total, rounded down.

Lightning Bolt

Lightning Bolt deals 3 damage to any target.

Thermo-Alchemist

Defender
{T}: Thermo-Alchemist deals 1 damage to each opponent.
Whenever you cast an instant or sorcery spell, untap Thermo-Alchemist.

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Havoc Festival

Players can't gain life.
At the beginning of each player's upkeep, that player loses half their life, rounded up.

Sanctum of Stone Fangs

At the beginning of your first main phase, each opponent loses X life and you gain X life, where X is the number of Shrines you control.

Valgavoth, Terror Eater

Flying, lifelink
Ward—Sacrifice three nonland permanents.
If a card you didn't control would be put into an opponent's graveyard from anywhere, exile it instead.
During your turn, you may play cards exiled with Valgavoth. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.

Desolation Twin

When you cast this spell, create a 10/10 colorless Eldrazi creature token.

Plague Spitter

At the beginning of your upkeep, Plague Spitter deals 1 damage to each creature and each player.
When Plague Spitter dies, it deals 1 damage to each creature and each player.

Combustible Gearhulk

First strike
When Combustible Gearhulk enters, target opponent may have you draw three cards. If the player doesn't, you mill three cards, then Combustible Gearhulk deals damage to that player equal to the total mana value of those cards.

Bane of Bala Ged

Whenever Bane of Bala Ged attacks, defending player exiles two permanents they control.

Florian, Voldaren Scion

First strike
At the beginning of each of your postcombat main phases, look at the top X cards of your library, where X is the total amount of life your opponents lost this turn. Exile one of those cards and put the rest on the bottom of your library in a random order. You may play the exiled card this turn.

Neheb, the Eternal

Afflict 3 (Whenever this creature becomes blocked, defending player loses 3 life.)
At the beginning of each of your postcombat main phases, add {R} for each 1 life your opponents have lost this turn.