Descent into Madness

At the beginning of your upkeep, put a despair counter on Descent into Madness, then each player exiles X permanents they control and/or cards from their hand, where X is the number of despair counters on Descent into Madness.

Smokestack

At the beginning of your upkeep, you may put a soot counter on Smokestack.
At the beginning of each player's upkeep, that player sacrifices a permanent of their choice for each soot counter on Smokestack.

Death of a Thousand Stings

Target player loses 1 life and you gain 1 life.
At the beginning of your upkeep, if you have more cards in hand than each opponent, you may return Death of a Thousand Stings from your graveyard to your hand.

Horobi, Death's Wail

Flying
Whenever a creature becomes the target of a spell or ability, destroy that creature.

Horobi's Whisper

If you control a Swamp, destroy target nonblack creature.
Splice onto Arcane—Exile four cards from your graveyard. (As you cast an Arcane spell, you may reveal this card from your hand and pay its splice cost. If you do, add this card's effects to that spell.)

Footsteps of the Goryo

Return target creature card from your graveyard to the battlefield. Sacrifice that creature at the beginning of the next end step.

Kyoki, Sanity's Eclipse

Whenever you cast a Spirit or Arcane spell, target opponent exiles a card from their hand.

Eerie Soultender

When Eerie Soultender enters, mill three cards. (Put the top three cards of your library into your graveyard.)
{4}{B}, Exile Eerie Soultender from your graveyard: Return another target creature card from your graveyard to your hand.

Goryo's Vengeance

Return target legendary creature card from your graveyard to the battlefield. That creature gains haste. Exile it at the beginning of the next end step.
Splice onto Arcane {2}{B} (As you cast an Arcane spell, you may reveal this card from your hand and pay its splice cost. If you do, add this card's effects to that spell.)

Urborg Scavengers

Whenever Urborg Scavengers enters or attacks, exile target card from a graveyard. Put a +1/+1 counter on Urborg Scavengers.
Urborg Scavengers has flying as long as a card exiled with it has flying. The same is true for first strike, double strike, deathtouch, haste, hexproof, indestructible, lifelink, menace, reach, trample, and vigilance.

Sickening Shoal

You may exile a black card with mana value X from your hand rather than pay this spell's mana cost.
Target creature gets -X/-X until end of turn.