Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Keen Duelist

At the beginning of your upkeep, you and target opponent each reveal the top card of your library. You each lose life equal to the mana value of the card revealed by the other player. You each put the card you revealed into your hand.

Festering Newt

When Festering Newt dies, target creature an opponent controls gets -1/-1 until end of turn. That creature gets -4/-4 instead if you control a creature named Bogbrew Witch.

Rowan, Scion of War

Menace
{T}: Spells you cast this turn that are black and/or red cost {X} less to cast, where X is the amount of life you lost this turn. Activate only as a sorcery.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Shard of the Nightbringer

Flying
Drain Life — When Shard of the Nightbringer enters, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.

Caustic Bronco

Whenever Caustic Bronco attacks, reveal the top card of your library and put it into your hand. You lose life equal to that card's mana value if Caustic Bronco isn't saddled. Otherwise, each opponent loses that much life.
Saddle 3 (Tap any number of other creatures you control with total power 3 or more: This Mount becomes saddled until end of turn. Saddle only as a sorcery.)

Tormented Hero

Tormented Hero enters tapped.
Heroic — Whenever you cast a spell that targets Tormented Hero, each opponent loses 1 life. You gain life equal to the life lost this way.

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Blood Tribute

Kicker—Tap an untapped Vampire you control. (You may tap a Vampire you control in addition to any other costs as you cast this spell.)
Target opponent loses half their life, rounded up. If this spell was kicked, you gain life equal to the life lost this way.

Kokusho, the Evening Star

Flying
When Kokusho, the Evening Star dies, each opponent loses 5 life. You gain life equal to the life lost this way.

Phyrexian Delver

When Phyrexian Delver enters, return target creature card from your graveyard to the battlefield. You lose life equal to that card's mana value.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Vengeful Warchief

Whenever you lose life for the first time each turn, put a +1/+1 counter on Vengeful Warchief. (Damage causes loss of life.)

Gonti's Machinations

Whenever you lose life for the first time each turn, you get {E}. (You get an energy counter. Damage causes loss of life.)
Pay {E}{E}, Sacrifice Gonti's Machinations: Each opponent loses 3 life. You gain life equal to the life lost this way.

Pain Seer

Inspired — Whenever Pain Seer becomes untapped, reveal the top card of your library and put that card into your hand. You lose life equal to that card's mana value.

Dark Tutelage

At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Malakir Bloodwitch

Flying, protection from white
When Malakir Bloodwitch enters, each opponent loses life equal to the number of Vampires you control. You gain life equal to the life lost this way.

Reanimate

Put target creature card from a graveyard onto the battlefield under your control. You lose life equal to its mana value.

Subversion

At the beginning of your upkeep, each opponent loses 1 life. You gain life equal to the life lost this way.

Treasonous Ogre

Dethrone (Whenever this creature attacks the player with the most life or tied for most life, put a +1/+1 counter on it.)
Pay 3 life: Add {R}.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Queen's Bay Paladin

Whenever Queen's Bay Paladin enters or attacks, return up to one target Vampire card from your graveyard to the battlefield with a finality counter on it. You lose life equal to its mana value. (If a creature with a finality counter on it would die, exile it instead.)

Servant of Tymaret

Inspired — Whenever Servant of Tymaret becomes untapped, each opponent loses 1 life. You gain life equal to the life lost this way.
{2}{B}: Regenerate Servant of Tymaret.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Ghastly Death Tyrant

When Ghastly Death Tyrant enters, choose one —
• Disintegration Ray — Destroy target enchantment an opponent controls. You lose life equal to its mana value.
• Death Ray — Creatures you control gain deathtouch until end of turn.

Harmless Offering

Target opponent gains control of target permanent you control.

Gempalm Polluter

Cycling {B}{B} ({B}{B}, Discard this card: Draw a card.)
When you cycle Gempalm Polluter, you may have target player lose life equal to the number of Zombies on the battlefield.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Dark Confidant

Bubbling Cauldron

{1}, {T}, Sacrifice a creature: You gain 4 life.
{1}, {T}, Sacrifice a creature named Festering Newt: Each opponent loses 4 life. You gain life equal to the life lost this way.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent of their choice or discards a card.

Lich's Tomb

You don't lose the game for having 0 or less life.
Whenever you lose life, sacrifice a permanent for each 1 life you lost. (Damage causes loss of life.)

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Darkstar Augur

Offspring {B} (You may pay an additional {B} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Flying
At the beginning of your upkeep, reveal the top card of your library and put that card into your hand. You lose life equal to its mana value.

Greven, Predator Captain

Menace
Greven, Predator Captain gets +X/+0, where X is the amount of life you've lost this turn.
Whenever Greven attacks, you may sacrifice another creature. If you do, you draw cards equal to that creature's power and you lose life equal to that creature's toughness.

Ob Nixilis of the Black Oath

+2: Each opponent loses 1 life. You gain life equal to the life lost this way.
−2: Create a 5/5 black Demon creature token with flying. You lose 2 life.
−8: You get an emblem with "{1}{B}, Sacrifice a creature: You gain X life and draw X cards, where X is the sacrificed creature's power."
Ob Nixilis of the Black Oath can be your commander.

Chancellor of the Dross

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life equal to the life lost this way.
Flying, lifelink

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Vampire Scrivener

Flying
Whenever you gain life during your turn, put a +1/+1 counter on Vampire Scrivener.
Whenever you lose life during your turn, put a +1/+1 counter on Vampire Scrivener.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin the Mirthless deals 13 damage to any target. You gain 13 life.