The Mindskinner

The Mindskinner can't be blocked.
If a source you control would deal damage to an opponent, prevent that damage and each opponent mills that many cards.

Thieving Magpie

Flying (This creature can't be blocked except by creatures with flying or reach.)
Whenever Thieving Magpie deals damage to an opponent, draw a card.

Stormtide Leviathan

Islandwalk (This creature can't be blocked as long as defending player controls an Island.)
All lands are Islands in addition to their other types.
Creatures without flying or islandwalk can't attack.

The Flood of Mars

Islandwalk (This creature can't be blocked as long as defending player controls an Island.)
Water Always Wins — Whenever The Flood of Mars attacks, put a flood counter on another target creature or land. If it's a creature, it becomes a copy of The Flood of Mars. If it's a land, it becomes an Island in addition to its other types.

Cybermat

Skulk (This creature can't be blocked by creatures with greater power.)
Whenever Cybermat attacks and isn't blocked, it gets +X/+0 until end of turn, where X is the number of attacking artifact creatures.

Ingenious Prodigy

Skulk (This creature can't be blocked by creatures with greater power.)
Ingenious Prodigy enters with X +1/+1 counters on it.
At the beginning of your upkeep, if Ingenious Prodigy has one or more +1/+1 counters on it, you may remove a +1/+1 counter from it. If you do, draw a card.

Silent Hallcreeper

Silent Hallcreeper can't be blocked.
Whenever Silent Hallcreeper deals combat damage to a player, choose one that hasn't been chosen —
• Put two +1/+1 counters on Silent Hallcreeper.
• Draw a card.
• Silent Hallcreeper becomes a copy of another target creature you control.

Mercurial Spelldancer

Mercurial Spelldancer can't be blocked.
Whenever you cast a noncreature spell, put an oil counter on Mercurial Spelldancer.
Whenever Mercurial Spelldancer deals combat damage to a player, you may remove two oil counters from it. If you do, when you next cast an instant or sorcery spell this turn, copy that spell. You may choose new targets for the copy.

Smoke Bomb

Flash
All creatures have shroud. (They can't be the targets of spells or abilities.)
At the beginning of your upkeep, sacrifice Smoke Bomb. When you do, target creature you control can't be blocked this turn.

Silver Shroud Costume

Flash
When Silver Shroud Costume enters, attach it to target creature you control. That creature gains shroud until end of turn. (It can't be the target of spells or abilities.)
Equipped creature can't be blocked.
Equip {3}

Blighted Agent

Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)
Blighted Agent can't be blocked.

Thada Adel, Acquisitor

Islandwalk (This creature can't be blocked as long as defending player controls an Island.)
Whenever Thada Adel, Acquisitor deals combat damage to a player, search that player's library for an artifact card and exile it. Then that player shuffles. Until end of turn, you may play that card.

The Hive

{5}, {T}: Create a 1/1 colorless Insect artifact creature token with flying named Wasp. (It can't be blocked except by creatures with flying or reach.)

Graaz, Unstoppable Juggernaut

Juggernauts you control attack each combat if able.
Juggernauts you control can't be blocked by Walls.
Other creatures you control have base power and toughness 5/3 and are Juggernauts in addition to their other creature types.

Reservoir Kraken

Trample, ward {2}
At the beginning of each combat, if Reservoir Kraken is untapped, any opponent may tap an untapped creature they control. If they do, tap Reservoir Kraken and create a 1/1 blue Fish creature token with "This creature can't be blocked."

Piracy Charm

Choose one —
• Target creature gains islandwalk until end of turn. (It can't be blocked as long as defending player controls an Island.)
• Target creature gets +2/-1 until end of turn.
• Target player discards a card.

Canoptek Wraith

Wraith Form — Canoptek Wraith can't be blocked.
Transdimensional Scout — When Canoptek Wraith deals combat damage to a player, you may pay {3} and sacrifice it. If you do, choose a land you control. Then search your library for up to two basic land cards which have the same name as the chosen land, put them onto the battlefield tapped, then shuffle.

Nuka-Nuke Launcher

Equipped creature gets +3/+0 and has intimidate. (It can't be blocked except by artifact creatures and/or creatures that share a color with it.)
Whenever equipped creature attacks, until the end of defending player's next turn, that player gets two rad counters whenever they cast a spell.
Equip {3}

Sleep with the Fishes

Enchant creature
When Sleep with the Fishes enters, tap enchanted creature and you create a 1/1 blue Fish creature token with "This creature can't be blocked."
Enchanted creature doesn't untap during its controller's untap step.

Enter the Enigma

Target creature can't be blocked this turn.
Draw a card.

Brotherhood Regalia

Equipped creature has ward {2}, is an Assassin in addition to its other types, and can't be blocked.
Equip legendary creature {1}
Equip {3} ({3}: Attach to target creature you control. Equip only as a sorcery.)

Ghostly Pilferer

Whenever Ghostly Pilferer becomes untapped, you may pay {2}. If you do, draw a card.
Whenever an opponent casts a spell from anywhere other than their hand, draw a card.
Discard a card: Ghostly Pilferer can't be blocked this turn.

Aqueous Form

Enchant creature
Enchanted creature can't be blocked.
Whenever enchanted creature attacks, scry 1. (Look at the top card of your library. You may put that card on the bottom.)

Nimble Brigand

Nimble Brigand can't be blocked if you've committed a crime this turn. (Targeting opponents, anything they control, and/or cards in their graveyards is a crime.)
Whenever Nimble Brigand deals combat damage to a player, draw a card.

Signal Pest

Battle cry (Whenever this creature attacks, each other attacking creature gets +1/+0 until end of turn.)
Signal Pest can't be blocked except by creatures with flying or reach.

Capsizing Wave

Return target creature to its owner's hand. (Then exile this card. You may cast the creature later from exile.)

Sword Coast Serpent

Sword Coast Serpent can't be blocked as long as you've cast a noncreature spell this turn.

Sword Coast Serpent // Capsizing Wave

Thassa, God of the Sea

Indestructible
As long as your devotion to blue is less than five, Thassa isn't a creature. (Each {U} in the mana costs of permanents you control counts toward your devotion to blue.)
At the beginning of your upkeep, scry 1.
{1}{U}: Target creature you control can't be blocked this turn.

Expedition Lookout

Defender
As long as an opponent has eight or more cards in their graveyard, Expedition Lookout can attack as though it didn't have defender and it can't be blocked.

Tromokratis

Tromokratis has hexproof unless it's attacking or blocking.
Tromokratis can't be blocked unless all creatures defending player controls block it. (If any creature that player controls doesn't block this creature, it can't be blocked.)

Open into Wonder

X target creatures can't be blocked this turn. Until end of turn, those creatures gain "Whenever this creature deals combat damage to a player, draw a card."

Cephalid Facetaker

Cephalid Facetaker can't be blocked.
At the beginning of combat on your turn, you may have Cephalid Facetaker become a copy of another target creature until end of turn, except it's 1/4 and has "This creature can't be blocked."

Slip Through Space

Devoid (This card has no color.)
Target creature can't be blocked this turn.
Draw a card.

Triton Shorestalker

Chasm Skulker

Whenever you draw a card, put a +1/+1 counter on Chasm Skulker.
When Chasm Skulker dies, create X 1/1 blue Squid creature tokens with islandwalk, where X is the number of +1/+1 counters on Chasm Skulker. (They can't be blocked as long as defending player controls an Island.)

Slither Blade

Ferropede

Ferropede can't be blocked.
Whenever Ferropede deals combat damage to a player, you may remove a counter from target permanent.

Tetsuko Umezawa, Fugitive

Creatures you control with power or toughness 1 or less can't be blocked.

Surge Engine

Defender
{U}: Surge Engine loses defender and gains "This creature can't be blocked."
{2}{U}: Surge Engine becomes blue and has base power and toughness 5/4. Activate only if Surge Engine doesn't have defender.
{4}{U}{U}: Draw three cards. Activate only if Surge Engine is blue and only once.

Trailblazer's Boots

Equipped creature has nonbasic landwalk. (It can't be blocked as long as defending player controls a nonbasic land.)
Equip {2}

Reverse the Polarity

Choose one —
• Counter all other spells.
• Switch each creature's power and toughness until end of turn.
• Creatures can't be blocked this turn.

You Come to a River

Choose one —
• Fight the Current — Return target nonland permanent to its owner's hand.
• Find a Crossing — Target creature gets +1/+0 until end of turn and can't be blocked this turn.

Rogue's Passage

{T}: Add {C}.
{4}, {T}: Target creature can't be blocked this turn.

Jailbreak Scheme

Spree (Choose one or more additional costs.)
+ {3} — Put a +1/+1 counter on target creature. It can't be blocked this turn.
+ {2} — Target artifact or creature's owner puts it on the top or bottom of their library.