Founding the Third Path

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — You may cast an instant or sorcery spell with mana value 1 or 2 from your hand without paying its mana cost.
II — Target player mills four cards.
III — Exile target instant or sorcery card from your graveyard. Copy it. You may cast the copy.

Desperate Bloodseeker

Lifelink
When Desperate Bloodseeker enters, target player mills two cards. (They put the top two cards of their library into their graveyard.)

Breach the Multiverse

Each player mills ten cards. For each player, choose a creature or planeswalker card in that player's graveyard. Put those cards onto the battlefield under your control. Then each creature you control becomes a Phyrexian in addition to its other types.

Go for the Throat

Can't Wake Up

Target player mills four cards. (Then exile this card. You may cast the creature later from exile.)

Cruel Somnophage

Cruel Somnophage's power and toughness are each equal to the number of creature cards in all graveyards.

Cruel Somnophage // Can't Wake Up

Hideous Fleshwheeler

Menace (This creature can't be blocked except by two or more creatures.)
When this creature transforms into Hideous Fleshwheeler, put target permanent card with mana value 2 or less from a graveyard onto the battlefield under your control.

Nezumi Freewheeler

Menace
When Nezumi Freewheeler enters, each player mills three cards. (To mill three cards, a player puts the top three cards of their library into their graveyard.)
{5}{W/P}: Transform Nezumi Freewheeler. Activate only as a sorcery. ({W/P} can be paid with either {W} or 2 life.)

Nezumi Freewheeler // Hideous Fleshwheeler

Disturbing Conversion

Flash
Enchant creature
When Disturbing Conversion enters, each player mills two cards.
Enchanted creature gets -X/-0, where X is the number of cards in its controller's graveyard.

Tinybones Joins Up

When Tinybones Joins Up enters, any number of target players each discard a card.
Whenever a legendary creature you control enters, any number of target players each mill a card and lose 1 life.

Jetsam

Each opponent mills three cards, then you may cast a spell from each opponent's graveyard without paying its mana cost. If a spell cast this way would be put into a graveyard, exile it instead.

Flotsam

Mill three cards. Investigate. (Create a Clue token. It's an artifact with "{2}, Sacrifice this artifact: Draw a card.")

Flotsam // Jetsam

Cut Down

Destroy target creature with total power and toughness 5 or less.

Restless Reef

Restless Reef enters tapped.
{T}: Add {U} or {B}.
{2}{U}{B}: Until end of turn, Restless Reef becomes a 4/4 blue and black Shark creature with deathtouch. It's still a land.
Whenever Restless Reef attacks, target player mills four cards.

Coral Colony

Defender
{1}{U}, {T}: Target player mills X cards, where X is the number of creatures you control with defender. (To mill a card, a player puts the top card of their library into their graveyard.)

Gnawing Vermin

When Gnawing Vermin enters, target player mills two cards.
When Gnawing Vermin dies, target creature you don't control gets -1/-1 until end of turn.

Deadly Cover-Up

As an additional cost to cast this spell, you may collect evidence 6.
Destroy all creatures. If evidence was collected, exile a card from an opponent's graveyard. Then search its owner's graveyard, hand, and library for any number of cards with that name and exile them. That player shuffles, then draws a card for each card exiled from their hand this way.

The Ancient One

Descend 8 — The Ancient One can't attack or block unless there are eight or more permanent cards in your graveyard.
{2}{U}{B}: Draw a card, then discard a card. When you discard a card this way, target player mills cards equal to its mana value.

Scrabbling Skullcrab

Eerie — Whenever an enchantment you control enters and whenever you fully unlock a Room, target player mills two cards. (They put the top two cards of their library into their graveyard.)

Delney, Streetwise Lookout

Creatures you control with power 2 or less can't be blocked by creatures with power 3 or greater.
If an ability of a creature you control with power 2 or less triggers, that ability triggers an additional time.

Unable to Scream

Enchant creature
Enchanted creature loses all abilities and is a Toy artifact creature with base power and toughness 0/2 in addition to its other types.
As long as enchanted creature is face down, it can't be turned face up.

Terisian Mindbreaker

Whenever Terisian Mindbreaker attacks, defending player mills half their library, rounded up.
Unearth {1}{U}{U}{U} ({1}{U}{U}{U}: Return this card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step or if it would leave the battlefield. Unearth only as a sorcery.)

Deepmuck Desperado

Whenever you commit a crime, each opponent mills three cards. This ability triggers only once each turn. (Targeting opponents, anything they control, and/or cards in their graveyards is a crime.)

The Mindskinner

The Mindskinner can't be blocked.
If a source you control would deal damage to an opponent, prevent that damage and each opponent mills that many cards.

Jace, the Perfected Mind

Compleated ({U/P} can be paid with {U} or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
+1: Until your next turn, up to one target creature gets -3/-0.
−2: Target player mills three cards. Then if a graveyard has twenty or more cards in it, you draw three cards. Otherwise, you draw a card.
−X: Target player mills three times X cards.

Fear of Impostors

Flash
When Fear of Impostors enters, counter target spell. Its controller manifests dread. (That player looks at the top two cards of their library, then puts one onto the battlefield face down as a 2/2 creature and the other into their graveyard. If it's a creature card, it can be turned face up any time for its mana cost.)

Valgavoth's Lair

Hexproof
Valgavoth's Lair enters tapped. As it enters, choose a color.
{T}: Add one mana of the chosen color.

Consuming Aberration

Consuming Aberration's power and toughness are each equal to the number of cards in your opponents' graveyards.
Whenever you cast a spell, each opponent reveals cards from the top of their library until they reveal a land card, then puts those cards into their graveyard.

Silent Hallcreeper

Silent Hallcreeper can't be blocked.
Whenever Silent Hallcreeper deals combat damage to a player, choose one that hasn't been chosen —
• Put two +1/+1 counters on Silent Hallcreeper.
• Draw a card.
• Silent Hallcreeper becomes a copy of another target creature you control.