Mindcrank

Whenever an opponent loses life, that player mills that many cards. (Damage causes loss of life.)

Ob Nixilis, Unshackled

Flying, trample
Whenever an opponent searches their library, that player sacrifices a creature of their choice and loses 10 life.
Whenever another creature dies, put a +1/+1 counter on Ob Nixilis, Unshackled.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Have

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Grievous Wound

Enchant player
Enchanted player can't gain life.
Whenever enchanted player is dealt damage, they lose half their life, rounded up.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters, each player loses a third of their life, rounded up.

Quietus Spike

Equipped creature has deathtouch.
Whenever equipped creature deals combat damage to a player, that player loses half their life, rounded up.
Equip {3}

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Dark Ritual

Blitzwing, Adaptive Assailant

Living metal (During your turn, this Vehicle is also a creature.)
At the beginning of combat on your turn, choose flying or indestructible at random. Blitzwing gains that ability until end of turn.
Whenever Blitzwing deals combat damage to a player, convert it.

Blitzwing, Cruel Tormentor

More Than Meets the Eye {3}{B} (You may cast this card converted for {3}{B}.)
At the beginning of your end step, target opponent loses life equal to the life that player lost this turn. If no life is lost this way, convert Blitzwing.

Blitzwing, Cruel Tormentor // Blitzwing, Adaptive Assailant

Liliana of the Dark Realms

+1: Search your library for a Swamp card, reveal it, put it into your hand, then shuffle.
−3: Target creature gets +X/+X or -X/-X until end of turn, where X is the number of Swamps you control.
−6: You get an emblem with "Swamps you control have '{T}: Add {B}{B}{B}{B}.'"

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Liliana of the Dark Realms Emblem

Swamps you control have '{T}: Add {B}{B}{B}{B}.'

Witch's Cottage

({T}: Add {B}.)
Witch's Cottage enters tapped unless you control three or more other Swamps.
When Witch's Cottage enters untapped, you may put target creature card from your graveyard on top of your library.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Plague Drone

Flying
Rot Fly — If an opponent would gain life, that player loses that much life instead.

Charcoal Diamond

Charcoal Diamond enters tapped.
{T}: Add {B}.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

The One Ring

Indestructible
When The One Ring enters, if you cast it, you gain protection from everything until your next turn.
At the beginning of your upkeep, you lose 1 life for each burden counter on The One Ring.
{T}: Put a burden counter on The One Ring, then draw a card for each burden counter on The One Ring.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Enduring Tenacity

Whenever you gain life, target opponent loses that much life.
When Enduring Tenacity dies, if it was a creature, return it to the battlefield under its owner's control. It's an enchantment. (It's not a creature.)

Nyx Lotus

Nyx Lotus enters tapped.
{T}: Choose a color. Add an amount of mana of that color equal to your devotion to that color. (Your devotion to a color is the number of mana symbols of that color in the mana costs of permanents you control.)

Great Unclean One

Reverberating Summons — At the beginning of your end step, each opponent loses 2 life. Then for each opponent who has less life than you, create a 1/3 black Demon creature token named Plaguebearer of Nurgle.

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Profane Command

Choose two —
• Target player loses X life.
• Return target creature card with mana value X or less from your graveyard to the battlefield.
• Target creature gets -X/-X until end of turn.
• Up to X target creatures gain fear until end of turn. (They can't be blocked except by artifact creatures and/or black creatures.)

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Falthis, Shadowcat Familiar

Commanders you control have menace and deathtouch.
Partner (You can have two commanders if both have partner.)

Ayara, First of Locthwain

Whenever Ayara, First of Locthwain or another black creature you control enters, each opponent loses 1 life and you gain 1 life.
{T}, Sacrifice another black creature: Draw a card.

Village Rites

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

Creeping Bloodsucker

At the beginning of your upkeep, Creeping Bloodsucker deals 1 damage to each opponent. You gain life equal to the damage dealt this way.

Swamp

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Baleful Mastery

You may pay {1}{B} rather than pay this spell's mana cost.
If the {1}{B} cost was paid, an opponent draws a card.
Exile target creature or planeswalker.

Temporal Extortion

When you cast this spell, any player may pay half their life, rounded up. If a player does, counter Temporal Extortion.
Take an extra turn after this one.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Loyal Subordinate

Menace (This creature can't be blocked except by two or more creatures.)
Lieutenant — At the beginning of combat on your turn, if you control your commander, each opponent loses 3 life.

Vampiric Tutor

Search your library for a card, then shuffle and put that card on top. You lose 2 life.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Caged Sun

As Caged Sun enters, choose a color.
Creatures you control of the chosen color get +1/+1.
Whenever a land's ability causes you to add one or more mana of the chosen color, add one additional mana of that color.

Withering Torment

Destroy target creature or enchantment. You lose 2 life.

Sign in Blood

Target player draws two cards and loses 2 life.

Black Market

Whenever a creature dies, put a charge counter on Black Market.
At the beginning of your first main phase, add {B} for each charge counter on Black Market.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Sol Ring

Shard of the Nightbringer

Flying
Drain Life — When Shard of the Nightbringer enters, if you cast it, target opponent loses half their life, rounded up. You gain life equal to the life lost this way.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Vein Ripper

Flying
Ward—Sacrifice a creature.
Whenever a creature dies, target opponent loses 2 life and you gain 2 life.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control.)
Equip {1}

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Night's Whisper

Go for the Throat

Scytheclaw

Living weapon (When this Equipment enters, create a 0/0 black Phyrexian Germ creature token, then attach this to it.)
Equipped creature gets +1/+1.
Whenever equipped creature deals combat damage to a player, that player loses half their life, rounded up.
Equip {3}

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Whispersilk Cloak

Equipped creature can't be blocked and has shroud. (It can't be the target of spells or abilities.)
Equip {2}

Nirkana Revenant

Whenever you tap a Swamp for mana, add an additional {B}.
{B}: Nirkana Revenant gets +1/+1 until end of turn.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Consuming Corruption

Consuming Corruption deals X damage to target creature or planeswalker and you gain X life, where X is the number of Swamps you control.

Jet Medallion

Black spells you cast cost {1} less to cast.

Unstoppable Slasher

Deathtouch
Whenever Unstoppable Slasher deals combat damage to a player, they lose half their life, rounded up.
When Unstoppable Slasher dies, if it had no counters on it, return it to the battlefield tapped under its owner's control with two stun counters on it.

Bubbling Muck

Until end of turn, whenever a player taps a Swamp for mana, that player adds an additional {B}.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)