Phial of Galadriel

If you would draw a card while you have no cards in hand, draw two cards instead.
If you would gain life while you have 5 or less life, you gain twice that much life instead.
{T}: Add one mana of any color.

Dark Suspicions

At the beginning of each opponent's upkeep, that player loses X life, where X is the number of cards in that player's hand minus the number of cards in your hand.

Lightning Skelemental

Trample, haste
Whenever Lightning Skelemental deals combat damage to a player, that player discards two cards.
At the beginning of the end step, sacrifice Lightning Skelemental.

Crucible of Worlds

Case of the Crimson Pulse

When this Case enters, discard a card, then draw two cards.
To solve — You have no cards in hand. (If unsolved, solve at the beginning of your end step.)
Solved — At the beginning of your upkeep, discard your hand, then draw two cards.

Avatar of Fury

If an opponent controls seven or more lands, this spell costs {6} less to cast.
Flying
{R}: Avatar of Fury gets +1/+0 until end of turn.

Gibbering Descent

At the beginning of each player's upkeep, that player loses 1 life and discards a card.
Hellbent — Skip your upkeep step if you have no cards in hand.
Madness {2}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Reckless Wurm

Trample
Madness {2}{R} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Hunted Bonebrute

Menace
When Hunted Bonebrute enters, target opponent creates two 1/1 white Dog creature tokens.
When Hunted Bonebrute dies, each opponent loses 3 life.
Disguise {1}{B}

Blood Scrivener

If you would draw a card while you have no cards in hand, instead you draw two cards and you lose 1 life.

Pyromancy

{3}, Discard a card at random: Pyromancy deals damage to any target equal to the mana value of the discarded card.

Necrogoyf

Necrogoyf's power is equal to the number of creature cards in all graveyards.
At the beginning of each player's upkeep, that player discards a card.
Madness {1}{B}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Kroxa, Titan of Death's Hunger

When Kroxa enters, sacrifice it unless it escaped.
Whenever Kroxa enters or attacks, each opponent discards a card, then each opponent who didn't discard a nonland card this way loses 3 life.
Escape—{B}{B}{R}{R}, Exile five other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)

Sire of Insanity

At the beginning of each end step, each player discards their hand.

Null Brooch

{2}, {T}, Discard your hand: Counter target noncreature spell.

Asylum Visitor

At the beginning of each player's upkeep, if that player has no cards in hand, you draw a card and you lose 1 life.
Madness {1}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Chainer, Nightmare Adept

Discard a card: You may cast a creature spell from your graveyard this turn. Activate only once each turn.
Whenever a nontoken creature you control enters, if you didn't cast it from your hand, it gains haste until your next turn.

Jagged Poppet

Whenever Jagged Poppet is dealt damage, discard that many cards.
Hellbent — Whenever Jagged Poppet deals combat damage to a player, if you have no cards in hand, that player discards cards equal to the damage.

Anthem of Rakdos

Whenever a creature you control attacks, it gets +2/+0 until end of turn and Anthem of Rakdos deals 1 damage to you.
Hellbent — As long as you have no cards in hand, if a source you control would deal damage to a permanent or player, it deals double that damage to that permanent or player instead.

Rakdos Pit Dragon

{R}{R}: Rakdos Pit Dragon gains flying until end of turn.
{R}: Rakdos Pit Dragon gets +1/+0 until end of turn.
Hellbent — Rakdos Pit Dragon has double strike as long as you have no cards in hand.

Fiery Temper

Fiery Temper deals 3 damage to any target.
Madness {R} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Anje Falkenrath

Haste
{T}, Discard a card: Draw a card.
Whenever you discard a card, if it has madness, untap Anje Falkenrath.

Twinstrike

Twinstrike deals 2 damage to each of two target creatures.
Hellbent — Destroy those creatures instead if you have no cards in hand.

Sea Gate Wreckage

{T}: Add {C}. ({C} represents colorless mana.)
{2}{C}, {T}: Draw a card. Activate only if you have no cards in hand.

Mindslicer

When Mindslicer dies, each player discards their hand.

Rotting Regisaur

At the beginning of your upkeep, discard a card.

Ghirapur Orrery

Each player may play an additional land on each of their turns.
At the beginning of each player's upkeep, if that player has no cards in hand, that player draws three cards.

Cunning Lethemancer

At the beginning of your upkeep, each player discards a card.

Demonfire

Demonfire deals X damage to any target. If a creature dealt damage this way would die this turn, exile it instead.
Hellbent — If you have no cards in hand, this spell can't be countered and the damage can't be prevented.

Bloodhall Priest

Whenever Bloodhall Priest enters or attacks, if you have no cards in hand, Bloodhall Priest deals 2 damage to any target.
Madness {1}{B}{R} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Avatar of Woe

If there are ten or more creature cards total in all graveyards, this spell costs {6} less to cast.
Fear (This creature can't be blocked except by artifact creatures and/or black creatures.)
{T}: Destroy target creature. It can't be regenerated.