Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Plague Drone

Flying
Rot Fly — If an opponent would gain life, that player loses that much life instead.

Happily Ever After

When Happily Ever After enters, each player gains 5 life and draws a card.
At the beginning of your upkeep, if there are five colors among permanents you control, there are six or more card types among permanents you control and/or cards in your graveyard, and your life total is greater than or equal to your starting life total, you win the game.

Mathas, Fiend Seeker

Menace
At the beginning of your end step, put a bounty counter on target creature an opponent controls. For as long as that creature has a bounty counter on it, it has "When this creature dies, each opponent draws a card and gains 2 life."

Harmless Offering

Target opponent gains control of target permanent you control.

Angel of Destiny

Flying, double strike
Whenever a creature you control deals combat damage to a player, you and that player each gain that much life.
At the beginning of your end step, if you have at least 15 life more than your starting life total, each player Angel of Destiny attacked this turn loses the game.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Wall of Shards

Defender, flying
Cumulative upkeep—An opponent gains 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Bazaar Trader

{T}: Target player gains control of target artifact, creature, or land you control.

Healing Hands

Duelist's Heritage

Whenever one or more creatures attack, you may have target attacking creature gain double strike until end of turn.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Mirror Universe

{T}, Sacrifice Mirror Universe: Exchange life totals with target opponent. Activate only during your upkeep.

Reward the Faithful

Any number of target players each gain life equal to the highest mana value among permanents you control.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Licia, Sanguine Tribune

This spell costs {1} less to cast for each 1 life you gained this turn.
First strike, lifelink
Pay 5 life: Put three +1/+1 counters on Licia, Sanguine Tribune. Activate only during your turn and only once each turn.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Grollub

Whenever Grollub is dealt damage, each opponent gains that much life.

Alms Beast

Creatures blocking or blocked by Alms Beast have lifelink.

Truce

Each player may draw up to two cards. For each card less than two a player draws this way, that player gains 2 life.

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Luminate Primordial

Vigilance
When Luminate Primordial enters, for each opponent, exile up to one target creature that player controls and that player gains life equal to its power.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Spiritual Sanctuary

At the beginning of each player's upkeep, if that player controls a Plains, they gain 1 life.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Armistice

{3}{W}{W}: You draw a card and target opponent gains 3 life.

Baleful Mastery

You may pay {1}{B} rather than pay this spell's mana cost.
If the {1}{B} cost was paid, an opponent draws a card.
Exile target creature or planeswalker.

Aria of Flame

When Aria of Flame enters, each opponent gains 10 life.
Whenever you cast an instant or sorcery spell, put a verse counter on Aria of Flame, then it deals damage equal to the number of verse counters on it to target player or planeswalker.

Temporary Truce

Rain of Gore

If a spell or ability would cause its controller to gain life, that player loses that much life instead.

Transcendence

You don't lose the game for having 0 or less life.
When you have 20 or more life, you lose the game.
Whenever you lose life, you gain 2 life for each 1 life you lost. (Damage dealt to you causes you to lose life.)

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Howling Mine

At the beginning of each player's draw step, if Howling Mine is untapped, that player draws an additional card.

Collapsing Borders

Domain — At the beginning of each player's upkeep, that player gains 1 life for each basic land type among lands they control. Then Collapsing Borders deals 3 damage to that player.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

False Cure

Until end of turn, whenever a player gains life, that player loses 2 life for each 1 life they gained.

Benevolent Offering

Choose an opponent. You and that player each create three 1/1 white Spirit creature tokens with flying.
Choose an opponent. You gain 2 life for each creature you control and that player gains 2 life for each creature they control.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Blessed Alliance

Escalate {2} (Pay this cost for each mode chosen beyond the first.)
Choose one or more —
• Target player gains 4 life.
• Untap up to two target creatures.
• Target opponent sacrifices an attacking creature.

Laquatus's Champion

When Laquatus's Champion enters, target player loses 6 life.
When Laquatus's Champion leaves the battlefield, that player gains 6 life.
{B}: Regenerate Laquatus's Champion.

Wedding Ring

When Wedding Ring enters, if it was cast, target opponent creates a token that's a copy of it.
Whenever an opponent who controls an artifact named Wedding Ring draws a card during their turn, you draw a card.
Whenever an opponent who controls an artifact named Wedding Ring gains life during their turn, you gain that much life.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Arbiter of Knollridge

Vigilance
When Arbiter of Knollridge enters, each player's life total becomes the highest life total among all players.

Condemn

Put target attacking creature on the bottom of its owner's library. Its controller gains life equal to its toughness.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Sigarda's Splendor

As Sigarda's Splendor enters, note your life total.
At the beginning of your upkeep, draw a card if your life total is greater than or equal to the last noted life total for Sigarda's Splendor. Then note your life total.
Whenever you cast a white spell, you gain 1 life.