Ambition's Cost

You draw three cards and you lose 3 life.

Invoke Despair

Target opponent sacrifices a creature of their choice. If they can't, they lose 2 life and you draw a card. Then repeat this process for an enchantment and a planeswalker.

Ancient Craving

Drivnod, Carnage Dominus

If a creature dying causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
{B/P}{B/P}, Exile three creature cards from your graveyard: Put an indestructible counter on Drivnod, Carnage Dominus. ({B/P} can be paid with either {B} or 2 life.)

Dark Deal

Each player discards all the cards in their hand, then draws that many cards minus one.

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Swamp

Howling Golem

Whenever Howling Golem attacks or blocks, each player draws a card.

Doom Blade

Fell Stinger

Deathtouch
Exploit (When this creature enters, you may sacrifice a creature.)
When Fell Stinger exploits a creature, target player draws two cards and loses 2 life.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Polluted Bonds

Whenever a land an opponent controls enters, that player loses 2 life and you gain 2 life.

Murder

Defile

Target creature gets -1/-1 until end of turn for each Swamp you control.

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Black Sun's Twilight

Up to one target creature gets -X/-X until end of turn. If X is 5 or more, return a creature card with mana value X or less from your graveyard to the battlefield tapped.

Massacre Wurm

When this creature enters, creatures your opponents control get -2/-2 until end of turn.
Whenever a creature an opponent controls dies, that player loses 2 life.

Unscrupulous Agent

When Unscrupulous Agent enters, target opponent exiles a card from their hand.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Fate Unraveler

Whenever an opponent draws a card, Fate Unraveler deals 1 damage to that player.

Sign in Blood

Target player draws two cards and loses 2 life.

Zenith Chronicler

Whenever a player casts their first multicolored spell each turn, each other player draws a card.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature of their choice.
• Each opponent sacrifices a creature token of their choice.
• Each opponent sacrifices a planeswalker of their choice.

Gixian Puppeteer

Whenever you draw your second card each turn, each opponent loses 2 life and you gain 2 life.
When Gixian Puppeteer dies, return another target creature card with mana value 3 or less from your graveyard to the battlefield.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• Dread Presence deals 2 damage to any target and you gain 2 life.

Gruesome Realization

Choose one —
• You draw two cards and you lose 2 life.
• Creatures your opponents control get -1/-1 until end of turn.

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Offer Immortality

Target creature gains deathtouch and indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Clockwork Fox

When Clockwork Fox leaves the battlefield, you draw two cards and each opponent draws a card.

Demolition Field

{T}: Add {C}.
{2}, {T}, Sacrifice this land: Destroy target nonbasic land an opponent controls. That land's controller may search their library for a basic land card, put it onto the battlefield, then shuffle. You may search your library for a basic land card, put it onto the battlefield, then shuffle.

Go for the Throat

Promise of Power

Choose one —
• You draw five cards and you lose 5 life.
• Create an X/X black Demon creature token with flying, where X is the number of cards in your hand.
Entwine {4} (Choose both if you pay the entwine cost.)

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Village Rites

As an additional cost to cast this spell, sacrifice a creature.
Draw two cards.

The Dross Pits

The Dross Pits enters tapped.
{T}: Add {B}.
{1}{B}, {T}, Sacrifice The Dross Pits: Draw a card.

The Mycosynth Gardens

{T}: Add {C}.
{1}, {T}: Add one mana of any color.
{X}, {T}: The Mycosynth Gardens becomes a copy of target nontoken artifact you control with mana value X.

Braids, Arisen Nightmare

At the beginning of your end step, you may sacrifice an artifact, creature, enchantment, land, or planeswalker. If you do, each opponent may sacrifice a permanent of their choice that shares a card type with it. For each opponent who doesn't, that player loses 2 life and you draw a card.

Damnable Pact

Target player draws X cards and loses X life.

Caress of Phyrexia

Target player draws three cards, loses 3 life, and gets three poison counters.

Gnat Miser

Each opponent's maximum hand size is reduced by one.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Vein Ripper

Flying
Ward—Sacrifice a creature.
Whenever a creature dies, target opponent loses 2 life and you gain 2 life.

Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Tyrite Sanctum

{T}: Add {C}.
{2}, {T}: Target legendary creature becomes a God in addition to its other types. Put a +1/+1 counter on it.
{4}, {T}, Sacrifice Tyrite Sanctum: Put an indestructible counter on target God.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Howling Mine

At the beginning of each player's draw step, if Howling Mine is untapped, that player draws an additional card.

Vraska, Betrayal's Sting

Compleated ({B/P} can be paid with {B} or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
0: You draw a card and you lose 1 life. Proliferate.
−2: Target creature becomes a Treasure artifact with "{T}, Sacrifice this artifact: Add one mana of any color" and loses all other card types and abilities.
−9: If target player has fewer than nine poison counters, they get a number of poison counters equal to the difference.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Infectious Inquiry

You draw two cards and you lose 2 life. Each opponent gets a poison counter.

Succumb to Temptation

Knight of Dusk's Shadow

Menace (This creature can't be blocked except by two or more creatures.)
Your opponents can't gain life.
{1}{B}: Knight of Dusk's Shadow gets +1/+1 until end of turn.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Long Goodbye

This spell can't be countered. (This includes by the ward ability.)
Destroy target creature or planeswalker with mana value 3 or less.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Cut Down

Destroy target creature with total power and toughness 5 or less.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Marauding Blight-Priest

Painful Lesson

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Blood Pact

Kothophed, Soul Hoarder

Flying
Whenever a permanent owned by another player is put into a graveyard from the battlefield, you draw a card and you lose 1 life.

Phyrexian Obliterator

Trample
Whenever a source deals damage to Phyrexian Obliterator, that source's controller sacrifices that many permanents of their choice.