Profaner of the Dead

Exploit (When this creature enters, you may sacrifice a creature.)
When Profaner of the Dead exploits a creature, return to their owners' hands all creatures your opponents control with toughness less than the exploited creature's toughness.

Hurricane

Hurricane deals X damage to each creature with flying and each player.

Blood Money

Destroy all creatures. For each nontoken creature destroyed this way, you create a tapped Treasure token.

Armageddon

Obliterate

This spell can't be countered.
Destroy all artifacts, creatures, and lands. They can't be regenerated.

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

The Meathook Massacre

When The Meathook Massacre enters, each creature gets -X/-X until end of turn.
Whenever a creature you control dies, each opponent loses 1 life.
Whenever a creature an opponent controls dies, you gain 1 life.

Whirlwind

Starstorm

Starstorm deals X damage to each creature.
Cycling {3} ({3}, Discard this card: Draw a card.)

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Akroma's Vengeance

Destroy all artifacts, creatures, and enchantments.
Cycling {3} ({3}, Discard this card: Draw a card.)

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Worldfire

Exile all permanents. Exile all cards from all hands and graveyards. Each player's life total becomes 1.

Back to Nature

Cyclone Summoner

When Cyclone Summoner enters, if you cast it from your hand, return all permanents to their owners' hands except for Giants, Wizards, and lands.

Devastation

Anger of the Gods

Anger of the Gods deals 3 damage to each creature. If a creature dealt damage this way would die this turn, exile it instead.

All Is Dust

Each player sacrifices all permanents they control that are one or more colors.

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Aetherize

Return all attacking creatures to their owner's hand.

Boompile

{T}: Flip a coin. If you win the flip, destroy all nonland permanents.

Rout

You may cast Rout as though it had flash if you pay {2} more to cast it. (You may cast it any time you could cast an instant.)
Destroy all creatures. They can't be regenerated.

Creeping Corrosion

Jokulhaups

Destroy all artifacts, creatures, and lands. They can't be regenerated.

Phyrexian Rebirth

Destroy all creatures, then create an X/X colorless Phyrexian Horror artifact creature token, where X is the number of creatures destroyed this way.

Deathbringer Regent

Flying
When Deathbringer Regent enters, if you cast it from your hand and there are five or more other creatures on the battlefield, destroy all other creatures.

Apocalypse

Exile all permanents. You discard your hand.

Wrath of God

Destroy all creatures. They can't be regenerated.

Marchesa, Resolute Monarch

Menace, deathtouch
Whenever Marchesa, Resolute Monarch attacks, remove all counters from up to one target permanent.
At the beginning of your upkeep, if you haven't been dealt combat damage since your last turn, you draw a card and you lose 1 life.

Invasion of Fiora

(As a Siege enters, choose an opponent to protect it. You and others can attack it. When it's defeated, exile it, then cast it transformed.)
When Invasion of Fiora enters, choose one or both —
• Destroy all legendary creatures.
• Destroy all nonlegendary creatures.

Invasion of Fiora // Marchesa, Resolute Monarch

Apex Altisaur

When Apex Altisaur enters, it fights up to one target creature you don't control.
Enrage — Whenever Apex Altisaur is dealt damage, it fights up to one target creature you don't control.

Whelming Wave

Return all creatures to their owners' hands except for Krakens, Leviathans, Octopuses, and Serpents.

Scourge of Fleets

When Scourge of Fleets enters, return each creature your opponents control with toughness X or less to its owner's hand, where X is the number of Islands you control.

Upheaval

Return all permanents to their owners' hands.

Whiptongue Hydra

Reach
When Whiptongue Hydra enters, destroy all creatures with flying. Put a +1/+1 counter on Whiptongue Hydra for each creature destroyed this way.

Wash Out

Return all permanents of the color of your choice to their owners' hands.

Evacuation

Return all creatures to their owners' hands.

Planar Cleansing

Dawn

Aftermath (Cast this spell only from your graveyard. Then exile it.)
Return all creature cards with power 2 or less from your graveyard to your hand.

Dusk

Destroy all creatures with power 3 or greater.

Dusk // Dawn

Nevinyrral's Disk

Nevinyrral's Disk enters tapped.
{1}, {T}: Destroy all artifacts, creatures, and enchantments.

Crux of Fate

Choose one —
• Destroy all Dragon creatures.
• Destroy all non-Dragon creatures.

The Great Aurora

Each player shuffles all cards from their hand and all permanents they own into their library, then draws that many cards. Each player may put any number of land cards from their hand onto the battlefield. Exile The Great Aurora.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Rolling Earthquake

Rolling Earthquake deals X damage to each creature without horsemanship and each player.

Crush of Tentacles

Surge {3}{U}{U} (You may cast this spell for its surge cost if you or a teammate has cast another spell this turn.)
Return all nonland permanents to their owners' hands. If this spell's surge cost was paid, create an 8/8 blue Octopus creature token.

Flood of Tears

Return all nonland permanents to their owners' hands. If you return four or more nontoken permanents you control this way, you may put a permanent card from your hand onto the battlefield.

Sunscour

You may exile two white cards from your hand rather than pay this spell's mana cost.
Destroy all creatures.

Fade from History

Each player who controls an artifact or enchantment creates a 2/2 green Bear creature token. Then destroy all artifacts and enchantments.

Ezuri's Predation

For each creature your opponents control, create a 4/4 green Phyrexian Beast creature token. Each of those tokens fights a different one of those creatures.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Inferno

Inferno deals 6 damage to each creature and each player.

Ruination

Wave of Vitriol

Each player sacrifices all artifacts, enchantments, and nonbasic lands they control. For each land sacrificed this way, its controller may search their library for a basic land card and put it onto the battlefield tapped. Then each player who searched their library this way shuffles.

Chain Reaction

Chain Reaction deals X damage to each creature, where X is the number of creatures on the battlefield.

Hour of Devastation

All creatures lose indestructible until end of turn. Hour of Devastation deals 5 damage to each creature and each non-Bolas planeswalker.

Damnation

Necromantic Selection

Destroy all creatures, then return a creature card put into a graveyard this way to the battlefield under your control. It's a black Zombie in addition to its other colors and types. Exile Necromantic Selection.

Spinning Wheel Kick

Target creature you control deals damage equal to its power to each of X target creatures and/or planeswalkers.

Vanquish the Horde

This spell costs {1} less to cast for each creature on the battlefield.
Destroy all creatures.

Decree of Annihilation

Exile all artifacts, creatures, and lands from the battlefield, all cards from all graveyards, and all cards from all hands.
Cycling {5}{R}{R} ({5}{R}{R}, Discard this card: Draw a card.)
When you cycle Decree of Annihilation, destroy all lands.

Cyclonic Rift

Return target nonland permanent you don't control to its owner's hand.
Overload {6}{U} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Plague Wind

Destroy all creatures you don't control. They can't be regenerated.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Play of the Game

Assist (Another player can pay up to {6} of this spell's cost.)
Exile all nonland permanents.

Fade Away

For each creature, its controller sacrifices a permanent unless they pay {1}.

In Garruk's Wake

Destroy all creatures you don't control and all planeswalkers you don't control.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Burn Down the House

Choose one —
• Burn Down the House deals 5 damage to each creature and each planeswalker.
• Create three 1/1 red Devil creature tokens with "When this creature dies, it deals 1 damage to any target." They gain haste until end of turn.

River's Rebuke

Return all nonland permanents target player controls to their owner's hand.

Spectral Deluge

Return each creature your opponents control with toughness X or less to its owner's hand, where X is the number of Islands you control.
Foretell {1}{U}{U} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)

Star of Extinction

Destroy target land. Star of Extinction deals 20 damage to each creature and each planeswalker.

Brotherhood's End

Choose one —
• Brotherhood's End deals 3 damage to each creature and each planeswalker.
• Destroy all artifacts with mana value 3 or less.