Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Infernal Grasp

Destroy target creature. You lose 2 life.

Isolated Chapel

Isolated Chapel enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Resplendent Angel

Flying
At the beginning of each end step, if you gained 5 or more life this turn, create a 4/4 white Angel creature token with flying and vigilance.
{3}{W}{W}{W}: Until end of turn, Resplendent Angel gets +2/+2 and gains lifelink.

Pontiff of Blight

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Other creatures you control have extort. (If a creature has multiple instances of extort, each triggers separately.)

Leeching Lurker

Lifelink
Nightbound (If a player casts at least two spells during their own turn, it becomes day next turn.)

Curse of Leeches

Enchant player
As this permanent transforms into Curse of Leeches, attach it to a player.
At the beginning of enchanted player's upkeep, they lose 1 life and you gain 1 life.
Daybound (If a player casts no spells during their own turn, it becomes night next turn.)

Curse of Leeches // Leeching Lurker

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters, you may pay 2 life. If you don't, it enters tapped.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Trespasser's Curse

Enchant player
Whenever a creature enchanted player controls enters, that player loses 1 life and you gain 1 life.

Exotic Orchard

{T}: Add one mana of any color that a land an opponent controls could produce.

Guardian Idol

Guardian Idol enters tapped.
{T}: Add {C}.
{2}: Guardian Idol becomes a 2/2 Golem artifact creature until end of turn.

Vampire Nighthawk

Flying
Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Heliod, Sun-Crowned

Indestructible
As long as your devotion to white is less than five, Heliod isn't a creature.
Whenever you gain life, put a +1/+1 counter on target creature or enchantment you control.
{1}{W}: Another target creature gains lifelink until end of turn.

Star Compass

Star Compass enters tapped.
{T}: Add one mana of any color that a basic land you control could produce.

Arcane Signet

Revenge of Ravens

Whenever a creature attacks you or a planeswalker you control, that creature's controller loses 1 life and you gain 1 life.

Kunoros, Hound of Athreos

Vigilance, menace, lifelink
Creature cards in graveyards can't enter the battlefield.
Players can't cast spells from graveyards.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

Sign in Blood

Target player draws two cards and loses 2 life.

Blind Obedience

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Artifacts and creatures your opponents control enter tapped.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Sorin the Mirthless

+1: Look at the top card of your library. You may reveal that card and put it into your hand. If you do, you lose life equal to its mana value.
−2: Create a 2/3 black Vampire creature token with flying and lifelink.
−7: Sorin the Mirthless deals 13 damage to any target. You gain 13 life.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Eye of Vecna

When Eye of Vecna enters, you draw a card and you lose 2 life.
At the beginning of your upkeep, you may pay {2}. If you do, you draw a card and you lose 2 life.

Nyx-Fleece Ram

At the beginning of your upkeep, you gain 1 life.

Venser's Journal

You have no maximum hand size.
At the beginning of your upkeep, you gain 1 life for each card in your hand.

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Aerial Responder

Scoured Barrens

This land enters tapped.
When this land enters, you gain 1 life.
{T}: Add {W} or {B}.

Cosmos Elixir

At the beginning of your end step, draw a card if your life total is greater than your starting life total. Otherwise, you gain 2 life.

Great Hall of Starnheim

Great Hall of Starnheim enters tapped.
{T}: Add {B}.
{W}{W}{B}, {T}, Sacrifice Great Hall of Starnheim and a creature you control: Create a 4/4 white Angel Warrior creature token with flying and vigilance. Activate only as a sorcery.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Hive of the Eye Tyrant

If you control two or more other lands, Hive of the Eye Tyrant enters tapped.
{T}: Add {B}.
{3}{B}: Until end of turn, Hive of the Eye Tyrant becomes a 3/3 black Beholder creature with menace and "Whenever this creature attacks, exile target card from defending player's graveyard." It's still a land.

Shambling Vent

Shambling Vent enters tapped.
{T}: Add {W} or {B}.
{1}{W}{B}: Shambling Vent becomes a 2/3 white and black Elemental creature with lifelink until end of turn. It's still a land.

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Orzhov Signet

Castle Locthwain

Castle Locthwain enters tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Everflowing Chalice

Multikicker {2} (You may pay an additional {2} any number of times as you cast this spell.)
Everflowing Chalice enters with a charge counter on it for each time it was kicked.
{T}: Add {C} for each charge counter on Everflowing Chalice.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Despark

Exile target permanent with mana value 4 or greater.

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Tempt with Treats

Create a Food token. (Then exile this card. You may cast the creature later from exile.)

Gumdrop Poisoner

Lifelink
When Gumdrop Poisoner enters, up to one target creature gets -X/-X until end of turn, where X is the amount of life you gained this turn.

Gumdrop Poisoner // Tempt with Treats

Mortify

Suture Priest

Whenever another creature you control enters, you may gain 1 life.
Whenever a creature an opponent controls enters, you may have that player lose 1 life.

Plains

Noxious Gearhulk

Menace
When Noxious Gearhulk enters, you may destroy another target creature. If a creature is destroyed this way, you gain life equal to its toughness.

Gisa, Glorious Resurrector

If a creature an opponent controls would die, exile it instead.
At the beginning of your upkeep, put all creature cards exiled with Gisa, Glorious Resurrector onto the battlefield under your control. They gain decayed. (A creature with decayed can't block. When it attacks, sacrifice it at end of combat.)

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Agent of Erebos

Constellation — Whenever Agent of Erebos or another enchantment you control enters, exile target player's graveyard.

Markov Purifier

Lifelink
At the beginning of your end step, if you gained life this turn, you may pay {2}. If you do, draw a card.

Approach of the Second Sun

If this spell was cast from your hand and you've cast another spell named Approach of the Second Sun this game, you win the game. Otherwise, put Approach of the Second Sun into its owner's library seventh from the top and you gain 7 life.

Speaker of the Heavens

Vigilance, lifelink (Attacking doesn't cause this creature to tap. Damage dealt by this creature also causes you to gain that much life.)
{T}: Create a 4/4 white Angel creature token with flying. Activate only if you have at least 7 life more than your starting life total and only as a sorcery.

Angel of Vitality

Flying
If you would gain life, you gain that much life plus 1 instead.
This creature gets +2/+2 as long as you have 25 or more life.

Soul Warden

Whenever another creature enters, you gain 1 life.

Liquimetal Torque

{T}: Add {C}.
{T}: Target nonland permanent becomes an artifact in addition to its other types until end of turn.

Erebos's Intervention

Choose one —
• Target creature gets -X/-X until end of turn. You gain X life.
• Exile up to twice X target cards from graveyards.

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature of their choice and you return up to one target creature card from your graveyard to your hand.

Daxos, Blessed by the Sun

Daxos's toughness is equal to your devotion to white. (Each {W} in the mana costs of permanents you control counts toward your devotion to white.)
Whenever another creature you control enters or dies, you gain 1 life.

Authority of the Consuls

Creatures your opponents control enter tapped.
Whenever a creature an opponent controls enters, you gain 1 life.

Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Hand of Vecna

At the beginning of combat on your turn, equipped creature or a creature you control named Vecna gets +X/+X until end of turn, where X is the number of cards in your hand.
Equip—Pay 1 life for each card in your hand.
Equip {2}

Pristine Talisman

Swamp

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Temple of Aclazotz

(Transforms from Arguel's Blood Fast.)
{T}: Add {B}.
{T}, Sacrifice a creature: You gain life equal to the sacrificed creature's toughness.

Arguel's Blood Fast

{1}{B}, Pay 2 life: Draw a card.
At the beginning of your upkeep, if you have 5 or less life, you may transform Arguel's Blood Fast.

Arguel's Blood Fast // Temple of Aclazotz

Return to Dust

Exile target artifact or enchantment. If you cast this spell during your main phase, you may exile up to one other target artifact or enchantment.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice this artifact: Draw two cards.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Liesa, Forgotten Archangel

Flying, lifelink
Whenever another nontoken creature you control dies, return that card to its owner's hand at the beginning of the next end step.
If a creature an opponent controls would die, exile it instead.

The Book of Vile Darkness

At the beginning of your end step, if you lost 2 or more life this turn, create a 2/2 black Zombie creature token.
{T}, Exile The Book of Vile Darkness and artifacts you control named Eye of Vecna and Hand of Vecna: Create Vecna, a legendary 8/8 black Zombie God creature token with indestructible and all triggered abilities of the exiled cards.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Essence Pulse

You gain 2 life. Each creature gets -X/-X until end of turn, where X is the amount of life you gained this turn.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Wall of Reverence

Defender, flying
At the beginning of your end step, you may gain life equal to the power of target creature you control.

Ambition's Cost

You draw three cards and you lose 3 life.

Suffer the Past

Exile X target cards from target player's graveyard. For each card exiled this way, that player loses 1 life and you gain 1 life.

Orzhov Basilica

Orzhov Basilica enters tapped.
When Orzhov Basilica enters, return a land you control to its owner's hand.
{T}: Add {W}{B}.

Sol Ring

Veinwitch Coven

Menace
Whenever you gain life, you may pay {B}. If you do, return target creature card from your graveyard to your hand.

Restless Fortress

Restless Fortress enters tapped.
{T}: Add {W} or {B}.
{2}{W}{B}: Restless Fortress becomes a 1/4 white and black Nightmare creature until end of turn. It's still a land.
Whenever Restless Fortress attacks, defending player loses 2 life and you gain 2 life.

Concealed Courtyard

Concealed Courtyard enters tapped unless you control two or fewer other lands.
{T}: Add {W} or {B}.

Consume

Target player sacrifices a creature with the greatest power among creatures they control. You gain life equal to its power.

Consecrate

Exile target card from a graveyard.
Draw a card.

Consecrate // Consume

Alhammarret's Archive

If you would gain life, you gain twice that much life instead.
If you would draw a card except the first one you draw in each of your draw steps, draw two cards instead.

Command the Dreadhorde

Choose any number of target creature and/or planeswalker cards in graveyards. Command the Dreadhorde deals damage to you equal to the total mana value of those cards. Put them onto the battlefield under your control.

Bloodthirsty Aerialist

Flying
Whenever you gain life, put a +1/+1 counter on Bloodthirsty Aerialist.

Greed

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Angel of Destiny

Flying, double strike
Whenever a creature you control deals combat damage to a player, you and that player each gain that much life.
At the beginning of your end step, if you have at least 15 life more than your starting life total, each player Angel of Destiny attacked this turn loses the game.