Tezzeret's Gambit

({U/P} can be paid with either {U} or 2 life.)
Draw two cards, then proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Aetherize

Return all attacking creatures to their owner's hand.

Moltensteel Dragon

({R/P} can be paid with either {R} or 2 life.)
Flying
{R/P}: Moltensteel Dragon gets +1/+0 until end of turn.

Worst Fears

You control target player during that player's next turn. Exile Worst Fears. (You see all cards that player could see and make all decisions for the player.)

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Scourge of the Skyclaves

Kicker {4}{B}
When you cast this spell, if it was kicked, each player loses half their life, rounded up.
Scourge of the Skyclaves's power and toughness are each equal to 20 minus the highest life total among players.

Krydle of Baldur's Gate

Whenever Krydle of Baldur's Gate deals combat damage to a player, that player loses 1 life and mills a card, then you gain 1 life and scry 1.
Whenever you attack, you may pay {2}. If you do, target creature can't be blocked this turn.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Aminatou's Augury

Exile the top eight cards of your library. You may put a land card from among them onto the battlefield. Until end of turn, for each nonland card type, you may cast a spell of that type from among the exiled cards without paying its mana cost.

Parnesse, the Subtle Brush

Whenever you or a permanent you control becomes the target of a spell or ability an opponent controls, counter that spell or ability unless that player pays 4 life.
Whenever you copy a spell, up to one target opponent may also copy that spell. They may choose new targets for that copy.

Magister Sphinx

Flying
When Magister Sphinx enters, target player's life total becomes 10.

Dimensional Breach

Exile all permanents. For as long as any of those cards remain exiled, at the beginning of each player's upkeep, that player returns one of the exiled cards they own to the battlefield.

Emergency Powers

Each player shuffles their hand and graveyard into their library, then draws seven cards. Exile Emergency Powers.
Addendum — If you cast this spell during your main phase, you may put a permanent card with mana value 7 or less from your hand onto the battlefield.

Nahiri, the Unforgiving

Compleated ({R/W/P} can be paid with {R}, {W}, or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
+1: Until your next turn, up to one target creature attacks a player each combat if able.
+1: Discard a card, then draw a card.
0: Exile target creature or Equipment card with mana value less than Nahiri's loyalty from your graveyard. Create a token that's a copy of it. That token gains haste. Exile it at the beginning of the next end step.

Mental Misstep

({U/P} can be paid with either {U} or 2 life.)
Counter target spell with mana value 1.

Angelic Enforcer

Flying
You have hexproof.
Angelic Enforcer's power and toughness are each equal to your life total.
Whenever Angelic Enforcer attacks, double your life total.

Enduring Angel

Flying, double strike
You have hexproof.
If your life total would be reduced to 0 or less, instead transform Enduring Angel and your life total becomes 3. Then if Enduring Angel didn't transform this way, you lose the game.

Enduring Angel // Angelic Enforcer

Mizzix's Mastery

Exile target card that's an instant or sorcery from your graveyard. For each card exiled this way, copy it, and you may cast the copy without paying its mana cost. Exile Mizzix's Mastery.
Overload {5}{R}{R}{R} (You may cast this spell for its overload cost. If you do, change "target" in its text to "each.")

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Marshland Bloodcaster

Flying
{1}{B}, {T}: Rather than pay the mana cost of the next spell you cast this turn, you may pay life equal to that spell's mana value.

Mite Overseer

First strike
During your turn, creature tokens you control get +1/+0 and have first strike.
{3}{W/P}: Create a 1/1 colorless Phyrexian Mite artifact creature token with toxic 1 and "This creature can't block." (Players dealt combat damage by it also get a poison counter. {W/P} can be paid with either {W} or 2 life.)

Compleated Conjurer

When this creature transforms into Compleated Conjurer, exile the top card of your library. Until the end of your next turn, you may play that card.

Captive Weird

Defender
{3}{R/P}: Transform Captive Weird. Activate only as a sorcery. ({R/P} can be paid with either {R} or 2 life.)

Captive Weird // Compleated Conjurer

Hit the Mother Lode

Discover 10. If the discovered card's mana value is less than 10, create a number of tapped Treasure tokens equal to the difference. (To discover 10, exile cards from the top of your library until you exile a nonland card with mana value 10 or less. Cast it without paying its mana cost or put it into your hand. Put the rest on the bottom in a random order.)

Sorin Markov

+2: Sorin Markov deals 2 damage to any target and you gain 2 life.
−3: Target opponent's life total becomes 10.
−7: You control target player during that player's next turn.

Exquisite Archangel

Flying
If you would lose the game, instead exile Exquisite Archangel and your life total becomes equal to your starting life total.

Defiler of Dreams

Flying
As an additional cost to cast blue permanent spells, you may pay 2 life. Those spells cost {U} less to cast if you paid life this way. This effect reduces only the amount of blue mana you pay.
Whenever you cast a blue permanent spell, draw a card.

Vraska, Betrayal's Sting

Compleated ({B/P} can be paid with {B} or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
0: You draw a card and you lose 1 life. Proliferate.
−2: Target creature becomes a Treasure artifact with "{T}, Sacrifice this artifact: Add one mana of any color" and loses all other card types and abilities.
−9: If target player has fewer than nine poison counters, they get a number of poison counters equal to the difference.

Torgaar, Famine Incarnate

As an additional cost to cast this spell, you may sacrifice any number of creatures. This spell costs {2} less to cast for each creature sacrificed this way.
When Torgaar, Famine Incarnate enters, up to one target player's life total becomes half their starting life total, rounded down.

Faithless Looting

Draw two cards, then discard two cards.
Flashback {2}{R} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Magmatic Insight

As an additional cost to cast this spell, discard a land card.
Draw two cards.

Ayara, Furnace Queen

At the beginning of combat on your turn, return up to one target artifact or creature card from your graveyard to the battlefield. It gains haste. Exile it at the beginning of the next end step.

Ayara, Widow of the Realm

{T}, Sacrifice another creature or artifact: Ayara, Widow of the Realm deals X damage to target opponent or battle and you gain X life, where X is the sacrificed permanent's mana value.
{5}{R/P}: Transform Ayara. Activate only as a sorcery. ({R/P} can be paid with either {R} or 2 life.)

Ayara, Widow of the Realm // Ayara, Furnace Queen

Captive Audience

Captive Audience enters under the control of an opponent of your choice.
At the beginning of your upkeep, choose one that hasn't been chosen —
• Your life total becomes 4.
• Discard your hand.
• Each opponent creates five 2/2 black Zombie creature tokens.

Archmage's Newt

Whenever Archmage's Newt deals combat damage to a player, target instant or sorcery card in your graveyard gains flashback until end of turn. The flashback cost is equal to its mana cost. That card gains flashback {0} until end of turn instead if Archmage's Newt is saddled. (You may cast that card from your graveyard for its flashback cost. Then exile it.)
Saddle 3

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Spellskite

{U/P}: Change a target of target spell or ability to Spellskite. ({U/P} can be paid with either {U} or 2 life.)

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Enlightened Tutor

Search your library for an artifact or enchantment card, reveal it, then shuffle and put that card on top.

Spined Thopter

({U/P} can be paid with either {U} or 2 life.)
Flying

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Case of the Ransacked Lab

Instant and sorcery spells you cast cost {1} less to cast.
To solve — You've cast four or more instant and sorcery spells this turn. (If unsolved, solve at the beginning of your end step.)
Solved — Whenever you cast an instant or sorcery spell, draw a card.

Wrath of God

Destroy all creatures. They can't be regenerated.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Death's Shadow

Death's Shadow gets -X/-X, where X is your life total.

Aeon Chronicler

Aeon Chronicler's power and toughness are each equal to the number of cards in your hand.
Suspend X—{X}{3}{U}. X can't be 0.
Whenever a time counter is removed from Aeon Chronicler while it's exiled, draw a card.

Wild Guess

As an additional cost to cast this spell, discard a card.
Draw two cards.

Providence

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, your life total becomes 26.
Your life total becomes 26.

Pith Driller

({B/P} can be paid with either {B} or 2 life.)
When Pith Driller enters, put a -1/-1 counter on target creature.

Hideous Fleshwheeler

Menace (This creature can't be blocked except by two or more creatures.)
When this creature transforms into Hideous Fleshwheeler, put target permanent card with mana value 2 or less from a graveyard onto the battlefield under your control.

Nezumi Freewheeler

Menace
When Nezumi Freewheeler enters, each player mills three cards. (To mill three cards, a player puts the top three cards of their library into their graveyard.)
{5}{W/P}: Transform Nezumi Freewheeler. Activate only as a sorcery. ({W/P} can be paid with either {W} or 2 life.)

Nezumi Freewheeler // Hideous Fleshwheeler

Vault Skirge

({B/P} can be paid with either {B} or 2 life.)
Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)

Beacon of Tomorrows

Target player takes an extra turn after this one. Shuffle Beacon of Tomorrows into its owner's library.

Night's Whisper

Worldfire

Exile all permanents. Exile all cards from all hands and graveyards. Each player's life total becomes 1.

Phyrexian Tyranny

Whenever a player draws a card, that player loses 2 life unless they pay {2}.

Blasphemous Act

This spell costs {1} less to cast for each creature on the battlefield.
Blasphemous Act deals 13 damage to each creature.

Hargilde, Kindly Runechanter

{T}: Add {C}{C}. Spend this mana only to cast artifact spells or activate abilities of artifacts.
Friends forever (You can have two commanders if both have friends forever.)

Drivnod, Carnage Dominus

If a creature dying causes a triggered ability of a permanent you control to trigger, that ability triggers an additional time.
{B/P}{B/P}, Exile three creature cards from your graveyard: Put an indestructible counter on Drivnod, Carnage Dominus. ({B/P} can be paid with either {B} or 2 life.)

Brainstorm

Draw three cards, then put two cards from your hand on top of your library in any order.

Flare of Duplication

You may sacrifice a nontoken red creature rather than pay this spell's mana cost.
Copy target instant or sorcery spell. You may choose new targets for the copy.

Eternity Vessel

Eternity Vessel enters with X charge counters on it, where X is your life total.
Landfall — Whenever a land you control enters, you may have your life total become the number of charge counters on Eternity Vessel.

Hex Parasite

{X}{B/P}: Remove up to X counters from target permanent. For each counter removed this way, Hex Parasite gets +1/+0 until end of turn. ({B/P} can be paid with either {B} or 2 life.)

Hidetsugu and Kairi

Flying
When Hidetsugu and Kairi enters, draw three cards, then put two cards from your hand on top of your library in any order.
When Hidetsugu and Kairi dies, exile the top card of your library. Target opponent loses life equal to its mana value. If it's an instant or sorcery card, you may cast it without paying its mana cost.

Apostle's Blessing

({W/P} can be paid with either {W} or 2 life.)
Target artifact or creature you control gains protection from artifacts or from the color of your choice until end of turn.

Cloud Key

As Cloud Key enters, choose artifact, creature, enchantment, instant, or sorcery.
Spells you cast of the chosen type cost {1} less to cast.

Kylox, Visionary Inventor

Menace, ward {2}, haste
Whenever Kylox, Visionary Inventor attacks, sacrifice any number of other creatures, then exile the top X cards of your library, where X is their total power. You may cast any number of instant and/or sorcery spells from among the exiled cards without paying their mana costs.

Highway Robbery

You may discard a card or sacrifice a land. If you do, draw two cards.
Plot {1}{R} (You may pay {1}{R} and exile this card from your hand. Cast it as a sorcery on a later turn without paying its mana cost. Plot only as a sorcery.)

Sokrates, Athenian Teacher

Defender
Sokrates, Athenian Teacher has hexproof as long as it's untapped.
Sokratic Dialogue — {T}: Until end of turn, target creature gains "If this creature would deal combat damage to a player, prevent that damage. This creature's controller and that player each draw half that many cards, rounded down."

Tormenting Voice

Angel of Grace

Flash
Flying
When Angel of Grace enters, until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.
{4}{W}{W}, Exile Angel of Grace from your graveyard: Your life total becomes 10.

Gut Shot

({R/P} can be paid with either {R} or 2 life.)
Gut Shot deals 1 damage to any target.

Spectacle Mage

Flying
Instant and sorcery spells you cast with mana value 5 or greater cost {1} less to cast.

Tree of Perdition

Defender
{T}: Exchange target opponent's life total with Tree of Perdition's toughness.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Forsaken Thresher

At the beginning of your first main phase, add one mana of any color.

Foreboding Statue

{T}: Add one mana of any color. Put an omen counter on Foreboding Statue.
At the beginning of your end step, if there are three or more omen counters on Foreboding Statue, untap it, then transform it.

Foreboding Statue // Forsaken Thresher

Defiler of Faith

Vigilance
As an additional cost to cast white permanent spells, you may pay 2 life. Those spells cost {W} less to cast if you paid life this way. This effect reduces only the amount of white mana you pay.
Whenever you cast a white permanent spell, create a 1/1 white Soldier creature token.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Lightning Greaves

Equipped creature has haste and shroud. (It can't be the target of spells or abilities.)
Equip {0}

Eternal Dominion

Search target opponent's library for an artifact, creature, enchantment, or land card. Put that card onto the battlefield under your control. Then that player shuffles.
Epic (For the rest of the game, you can't cast spells. At the beginning of each of your upkeeps, copy this spell except for its epic ability. You may choose a new target for the copy.)

Unexpected Windfall

As an additional cost to cast this spell, discard a card.
Draw two cards and create two Treasure tokens. (They're artifacts with "{T}, Sacrifice this artifact: Add one mana of any color.")

Invincible Hymn

Count the number of cards in your library. Your life total becomes that number.

Dig Through Time

Delve (Each card you exile from your graveyard while casting this spell pays for {1}.)
Look at the top seven cards of your library. Put two of them into your hand and the rest on the bottom of your library in any order.

Collision of Realms

Each player shuffles all creatures they own into their library. Each player who shuffled a nontoken creature into their library this way reveals cards from the top of their library until they reveal a creature card, then puts that card onto the battlefield and the rest on the bottom of their library in a random order.

Shadow of Mortality

If your life total is less than your starting life total, this spell costs {X} less to cast, where X is the difference.

Skrelv, Defector Mite

Toxic 1 (Players dealt combat damage by this creature also get a poison counter.)
Skrelv, Defector Mite can't block.
{W/P}, {T}: Choose a color. Another target creature you control gains toxic 1 and hexproof from that color until end of turn. It can't be blocked by creatures of that color this turn. ({W/P} can be paid with either {W} or 2 life.)

Volcano Hellion

Volcano Hellion has echo {X}, where X is your life total. (At the beginning of your upkeep, if this came under your control since the beginning of your last upkeep, sacrifice it unless you pay its echo cost.)
When Volcano Hellion enters, it deals an amount of damage of your choice to you and target creature. The damage can't be prevented.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Hoarding Dragon

Flying
When this creature enters, you may search your library for an artifact card, exile it, then shuffle.
When this creature dies, you may put the exiled card into its owner's hand.

Behold the Beyond

Discard your hand. Search your library for three cards, put them into your hand, then shuffle.

Cruel Entertainment

Choose target player and another target player. The first player controls the second player during the second player's next turn, and the second player controls the first player during the first player's next turn.

Sorin's Vengeance

Sorin's Vengeance deals 10 damage to target player or planeswalker and you gain 10 life.

Master of Cruelties

First strike, deathtouch
Master of Cruelties can only attack alone.
Whenever Master of Cruelties attacks a player and isn't blocked, that player's life total becomes 1. Master of Cruelties assigns no combat damage this combat.

Cathartic Reunion

As an additional cost to cast this spell, discard two cards.
Draw three cards.

Rona, Tolarian Obliterator

Trample
Whenever a source deals damage to Rona, Tolarian Obliterator, that source's controller exiles a card from their hand at random. If it's a land card, you may put it onto the battlefield under your control. Otherwise, you may cast it without paying its mana cost.