Blood Pact

Target player draws two cards and loses 2 life.

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Dire Fleet Ravager

Menace, deathtouch
When Dire Fleet Ravager enters, each player loses a third of their life, rounded up.

Fell

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Karn Liberated

+4: Target player exiles a card from their hand.
−3: Exile target permanent.
−14: Restart the game, leaving in exile all non-Aura permanent cards exiled with Karn Liberated. Then put those cards onto the battlefield under your control.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Vraska, Betrayal's Sting

Compleated ({B/P} can be paid with {B} or 2 life. If life was paid, this planeswalker enters with two fewer loyalty counters.)
0: You draw a card and you lose 1 life. Proliferate.
−2: Target creature becomes a Treasure artifact with "{T}, Sacrifice this artifact: Add one mana of any color" and loses all other card types and abilities.
−9: If target player has fewer than nine poison counters, they get a number of poison counters equal to the difference.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Necrologia

Cast this spell only during your end step.
As an additional cost to cast this spell, pay X life.
Draw X cards.

Greed

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Doom Blade

Necrodominance

Skip your draw step.
At the beginning of your end step, you may pay any amount of life. If you do, draw that many cards.
Your maximum hand size is five.
If a card or token would be put into your graveyard from anywhere, exile it instead.

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

The War in Heaven

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — You draw three cards and you lose 3 life.
II — Mill three cards.
III — Choose up to three target creature cards with total mana value 8 or less in your graveyard. Return each of them to the battlefield with a necrodermis counter on it. They're artifacts in addition to their other types.

Orcish Bowmasters

Flash
When Orcish Bowmasters enters and whenever an opponent draws a card except the first one they draw in each of their draw steps, Orcish Bowmasters deals 1 damage to any target. Then amass Orcs 1.

Commander's Sphere

{T}: Add one mana of any color in your commander's color identity.
Sacrifice Commander's Sphere: Draw a card.

Burnished Hart

{3}, Sacrifice Burnished Hart: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Dregs of Sorrow

Destroy X target nonblack creatures. Draw X cards.

Finale of Eternity

Destroy up to three target creatures with toughness X or less. If X is 10 or more, return all creature cards from your graveyard to the battlefield.

Gemstone Caverns

If Gemstone Caverns is in your opening hand and you're not the starting player, you may begin the game with Gemstone Caverns on the battlefield with a luck counter on it. If you do, exile a card from your hand.
{T}: Add {C}. If Gemstone Caverns has a luck counter on it, instead add one mana of any color.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Chromatic Orrery

You may spend mana as though it were mana of any color.
{T}: Add {C}{C}{C}{C}{C}.
{5}, {T}: Draw a card for each color among permanents you control.

Vislor Turlough

Deal with the Black Guardian — When Vislor Turlough enters, you may have an opponent gain control of it. If you do, it's goaded for as long as they control it.
At the beginning of your end step, draw a card, then you lose life equal to the number of cards in your hand.
Doctor's companion (You can have two commanders if the other is the Doctor.)

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Promise of Power

Choose one —
• You draw five cards and you lose 5 life.
• Create an X/X black Demon creature token with flying, where X is the number of cards in your hand.
Entwine {4} (Choose both if you pay the entwine cost.)

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Deserted Temple

{T}: Add {C}.
{1}, {T}: Untap target land.

Sol Ring

Fatal Push

Destroy target creature if it has mana value 2 or less.
Revolt — Destroy that creature if it has mana value 4 or less instead if a permanent you controlled left the battlefield this turn.

Starscream, Seeker Leader

Living metal (During your turn, this Vehicle is also a creature.)
Flying, menace, haste
Whenever Starscream deals combat damage to a player, if there is no monarch, that player becomes the monarch.
Whenever you become the monarch, convert Starscream.

Starscream, Power Hungry

More Than Meets the Eye {2}{B} (You may cast this card converted for {2}{B}.)
Flying
Whenever you draw a card, if you're the monarch, target opponent loses 2 life.
Whenever one or more creatures deal combat damage to you, convert Starscream.

Starscream, Power Hungry // Starscream, Seeker Leader

Phyrexian Etchings

Cumulative upkeep {B} (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)
At the beginning of your end step, draw a card for each age counter on Phyrexian Etchings.
When Phyrexian Etchings is put into a graveyard from the battlefield, you lose 2 life for each age counter on it.

Damnable Pact

Target player draws X cards and loses X life.

Mana Vault

Mana Vault doesn't untap during your untap step.
At the beginning of your upkeep, you may pay {4}. If you do, untap Mana Vault.
At the beginning of your draw step, if Mana Vault is tapped, it deals 1 damage to you.
{T}: Add {C}{C}{C}.

Come Back Wrong

Destroy target creature. If a creature card is put into a graveyard this way, return it to the battlefield under your control. Sacrifice it at the beginning of your next end step.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Archfiend of Despair

Flying
Your opponents can't gain life.
At the beginning of each end step, each opponent loses life equal to the life that player lost this turn. (Damage causes loss of life.)

Murder

Ancient Craving

You draw three cards and you lose 3 life.

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Succumb to Temptation

Ambition's Cost

Baleful Force

At the beginning of each upkeep, you draw a card and you lose 1 life.

Swamp

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Blood Divination

As an additional cost to cast this spell, sacrifice a creature.
Draw three cards.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Anvil of Bogardan

Players have no maximum hand size.
At the beginning of each player's draw step, that player draws an additional card, then discards a card.

Basalt Monolith

Basalt Monolith doesn't untap during your untap step.
{T}: Add {C}{C}{C}.
{3}: Untap Basalt Monolith.

Armageddon Clock

At the beginning of your upkeep, put a doom counter on Armageddon Clock.
At the beginning of your draw step, Armageddon Clock deals damage equal to the number of doom counters on it to each player.
{4}: Remove a doom counter from Armageddon Clock. Any player may activate this ability but only during any upkeep step.

Grim Monolith

Grim Monolith doesn't untap during your untap step.
{T}: Add {C}{C}{C}.
{4}: Untap Grim Monolith.

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Solemn Simulacrum

When Solemn Simulacrum enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When Solemn Simulacrum dies, you may draw a card.

Tevesh Szat, Doom of Fools

+2: Create two 0/1 black Thrull creature tokens.
+1: You may sacrifice another creature or planeswalker. If you do, draw two cards, then draw another card if the sacrificed permanent was a commander.
−10: Gain control of all commanders. Put all commanders from the command zone onto the battlefield under your control.
Tevesh Szat, Doom of Fools can be your commander.
Partner

Book of Rass

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Infectious Curse

Enchant player
Spells you cast that target enchanted player cost {1} less to cast.
At the beginning of enchanted player's upkeep, that player loses 1 life and you gain 1 life.

Accursed Witch

Spells your opponents cast that target Accursed Witch cost {1} less to cast.
When Accursed Witch dies, return it to the battlefield transformed under your control attached to target opponent.

Accursed Witch // Infectious Curse

Mana Crypt

At the beginning of your upkeep, flip a coin. If you lose the flip, Mana Crypt deals 3 damage to you.
{T}: Add {C}{C}.

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Breathe Your Last

Destroy target creature or planeswalker. You gain 1 life for each of its colors.

Feed the Infection

You draw three cards and you lose 3 life.
Corrupted — Each opponent who has three or more poison counters loses 3 life.

Rings of Brighthearth

Whenever you activate an ability, if it isn't a mana ability, you may pay {2}. If you do, copy that ability. You may choose new targets for the copy.

Lich's Mastery

Hexproof
You can't lose the game.
Whenever you gain life, draw that many cards.
Whenever you lose life, for each 1 life you lost, exile a permanent you control or a card from your hand or graveyard.
When Lich's Mastery leaves the battlefield, you lose the game.

Gravestorm

At the beginning of your upkeep, target opponent may exile a card from their graveyard. If that player doesn't, you may draw a card.

Stromgald Cabal

{T}, Pay 1 life: Counter target white spell.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.