Case of the Ransacked Lab

Instant and sorcery spells you cast cost {1} less to cast.
To solve — You've cast four or more instant and sorcery spells this turn. (If unsolved, solve at the beginning of your end step.)
Solved — Whenever you cast an instant or sorcery spell, draw a card.

Dreamtide Whale

Vanishing 2 (This creature enters with two time counters on it. At the beginning of your upkeep, remove a time counter from it. When the last is removed, sacrifice it.)
Whenever a player casts their second spell each turn, proliferate. (Choose any number of permanents and/or players, then give each another counter of each kind already there.)

Inspiring Call

Draw a card for each creature you control with a +1/+1 counter on it. Those creatures gain indestructible until end of turn. (Damage and effects that say "destroy" don't destroy them.)

Master Chef

Commander creatures you own have "This creature enters with an additional +1/+1 counter on it" and "Other creatures you control enter with an additional +1/+1 counter on them."

Island

Thrumming Stone

Spells you cast have ripple 4. (Whenever you cast a spell, you may reveal the top four cards of your library. You may cast spells with the same name as that spell from among the revealed cards without paying their mana costs. Put the rest on the bottom of your library.)

Emerald Medallion

Green spells you cast cost {1} less to cast.

Forest

Archmage Emeritus

Magecraft — Whenever you cast or copy an instant or sorcery spell, draw a card.

Doc Aurlock, Grizzled Genius

Spells you cast from your graveyard or from exile cost {2} less to cast.
Plotting cards from your hand costs {2} less.

Sol Ring

Frantic Search

Draw two cards, then discard two cards. Untap up to three lands.

Adrix and Nev, Twincasters

Ward {2} (Whenever this creature becomes the target of a spell or ability an opponent controls, counter it unless that player pays {2}.)
If one or more tokens would be created under your control, twice that many of those tokens are created instead.

Gale, Waterdeep Prodigy

Whenever you cast an instant or sorcery spell from your hand, you may cast up to one target card of the other type from your graveyard. If a spell cast from your graveyard this way would be put into your graveyard, exile it instead.
Choose a Background (You can have a Background as a second commander.)

Thunderclap Drake

Flying
Instant and sorcery spells you cast cost {1} less to cast.
{2}{U}, Sacrifice Thunderclap Drake: When you next cast an instant or sorcery spell this turn, copy it for each time you've cast your commander from the command zone this game. You may choose new targets for the copies.

Sphinx of the Chimes

Flying
Discard two nonland cards with the same name: Draw four cards.

Slime Against Humanity

Create a 0/0 green Ooze creature token with trample. Put X +1/+1 counters on it, where X is two plus the total number of cards you own in exile and in your graveyard that are Oozes or are named Slime Against Humanity.
A deck can have any number of cards named Slime Against Humanity.