Serum Powder

{T}: Add {C}.
Any time you could mulligan and Serum Powder is in your hand, you may exile all the cards from your hand, then draw that many cards. (You can do this in addition to taking mulligans.)

Leyline of Abundance

If Leyline of Abundance is in your opening hand, you may begin the game with it on the battlefield.
Whenever you tap a creature for mana, add an additional {G}.
{6}{G}{G}: Put a +1/+1 counter on each creature you control.

Gandalf, Westward Voyager

Whenever you cast a spell with mana value 5 or greater, each opponent reveals the top card of their library. If any of those cards shares a card type with that spell, copy that spell, you may choose new targets for the copy, and each opponent draws a card. Otherwise, you draw a card. (A copy of a permanent spell becomes a token.)

Gilanra, Caller of Wirewood

{T}: Add {G}. When you spend this mana to cast a spell with mana value 6 or greater, draw a card.
Partner (You can have two commanders if both have partner.)

Bello, Bard of the Brambles

During your turn, each non-Equipment artifact and non-Aura enchantment you control with mana value 4 or greater is a 4/4 Elemental creature in addition to its other types and has indestructible, haste, and "Whenever this creature deals combat damage to a player, draw a card."

Leyline of the Void

If Leyline of the Void is in your opening hand, you may begin the game with it on the battlefield.
If a card would be put into an opponent's graveyard from anywhere, exile it instead.

Leyline of Combustion

If Leyline of Combustion is in your opening hand, you may begin the game with it on the battlefield.
Whenever you and/or at least one permanent you control becomes the target of a spell or ability an opponent controls, Leyline of Combustion deals 2 damage to that player.

Providence

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, your life total becomes 26.
Your life total becomes 26.

Bringer of the Black Dawn

You may pay {W}{U}{B}{R}{G} rather than pay this spell's mana cost.
Trample
At the beginning of your upkeep, you may pay 2 life. If you do, search your library for a card, then shuffle and put that card on top.

Devourer of Destiny

You may reveal this card from your opening hand. If you do, at the beginning of your first upkeep, look at the top four cards of your library. You may put one of those cards back on top of your library. Exile the rest.
When you cast this spell, exile target permanent that's one or more colors.

Leyline of Resonance

If Leyline of Resonance is in your opening hand, you may begin the game with it on the battlefield.
Whenever you cast an instant or sorcery spell that targets only a single creature you control, copy that spell. You may choose new targets for the copy.

Happily Ever After

When Happily Ever After enters, each player gains 5 life and draws a card.
At the beginning of your upkeep, if there are five colors among permanents you control, there are six or more card types among permanents you control and/or cards in your graveyard, and your life total is greater than or equal to your starting life total, you win the game.

Leyline of Lightning

If Leyline of Lightning is in your opening hand, you may begin the game with it on the battlefield.
Whenever you cast a spell, you may pay {1}. If you do, Leyline of Lightning deals 1 damage to target player or planeswalker.

Gemstone Caverns

If Gemstone Caverns is in your opening hand and you're not the starting player, you may begin the game with Gemstone Caverns on the battlefield with a luck counter on it. If you do, exile a card from your hand.
{T}: Add {C}. If Gemstone Caverns has a luck counter on it, instead add one mana of any color.

Leyline of Anticipation

If Leyline of Anticipation is in your opening hand, you may begin the game with it on the battlefield.
You may cast spells as though they had flash.

Leyline of Sanctity

If Leyline of Sanctity is in your opening hand, you may begin the game with it on the battlefield.
You have hexproof. (You can't be the target of spells or abilities your opponents control.)

Bringer of the White Dawn

You may pay {W}{U}{B}{R}{G} rather than pay this spell's mana cost.
Trample
At the beginning of your upkeep, you may return target artifact card from your graveyard to the battlefield.

Chancellor of the Dross

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent loses 3 life, then you gain life equal to the life lost this way.
Flying, lifelink

Helga, Skittish Seer

Whenever you cast a creature spell with mana value 4 or greater, you draw a card, gain 1 life, and put a +1/+1 counter on Helga, Skittish Seer.
{T}: Add X mana of any one color, where X is Helga, Skittish Seer's power. Spend this mana only to cast creature spells with mana value 4 or greater or creature spells with {X} in their mana costs.

Chancellor of the Spires

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, each opponent mills seven cards.
Flying
When Chancellor of the Spires enters, you may cast target instant or sorcery card from an opponent's graveyard without paying its mana cost.

Up the Beanstalk

When Up the Beanstalk enters and whenever you cast a spell with mana value 5 or greater, draw a card.

Leyline of Transformation

If Leyline of Transformation is in your opening hand, you may begin the game with it on the battlefield.
As Leyline of Transformation enters, choose a creature type.
Creatures you control are the chosen type in addition to their other types. The same is true for creature spells you control and creature cards you own that aren't on the battlefield.

Leyline of Mutation

If Leyline of Mutation is in your opening hand, you may begin the game with it on the battlefield.
You may pay {W}{U}{B}{R}{G} rather than pay the mana cost for spells you cast.

Leyline of Lifeforce

If Leyline of Lifeforce is in your opening hand, you may begin the game with it on the battlefield.
Creature spells can't be countered.

Chancellor of the Forge

You may reveal this card from your opening hand. If you do, at the beginning of the first upkeep, create a 1/1 red Phyrexian Goblin creature token with haste.
When Chancellor of the Forge enters, create X 1/1 red Phyrexian Goblin creature tokens with haste, where X is the number of creatures you control.

Leyline of Singularity

If Leyline of Singularity is in your opening hand, you may begin the game with it on the battlefield.
All nonland permanents are legendary.

Chancellor of the Annex

You may reveal this card from your opening hand. If you do, when each opponent casts their first spell of the game, counter that spell unless that player pays {1}.
Flying
Whenever an opponent casts a spell, counter it unless that player pays {1}.

Henzie "Toolbox" Torre

Each creature spell you cast with mana value 4 or greater has blitz. The blitz cost is equal to its mana cost. (You may choose to cast that spell for its blitz cost. If you do it gains haste and "When this creature dies, draw a card." Sacrifice it at the beginning of the next end step.)
Blitz costs you pay cost {1} less for each time you've cast your commander from the command zone this game.

Leyline of Punishment

If Leyline of Punishment is in your opening hand, you may begin the game with it on the battlefield.
Players can't gain life.
Damage can't be prevented.

Bringer of the Blue Dawn

You may pay {W}{U}{B}{R}{G} rather than pay this spell's mana cost.
Trample
At the beginning of your upkeep, you may draw two cards.

Once Upon a Time

If this spell is the first spell you've cast this game, you may cast it without paying its mana cost.
Look at the top five cards of your library. You may reveal a creature or land card from among them and put it into your hand. Put the rest on the bottom of your library in a random order.

Chancellor of the Tangle

You may reveal this card from your opening hand. If you do, at the beginning of your first main phase of the game, add {G}.
Vigilance, reach

Bringer of the Green Dawn

You may pay {W}{U}{B}{R}{G} rather than pay this spell's mana cost.
Trample
At the beginning of your upkeep, you may create a 3/3 green Beast creature token.

Sphinx of Foresight

You may reveal this card from your opening hand. If you do, scry 3 at the beginning of your first upkeep.
Flying
At the beginning of your upkeep, scry 1.

Leyline of the Guildpact

If Leyline of the Guildpact is in your opening hand, you may begin the game with it on the battlefield.
Each nonland permanent you control is all colors.
Lands you control are every basic land type in addition to their other types.

Ascendant Packleader

Ascendant Packleader enters with a +1/+1 counter on it if you control a permanent with mana value 4 or greater.
Whenever you cast a spell with mana value 4 or greater, put a +1/+1 counter on Ascendant Packleader.

Leyline Axe

If this card is in your opening hand, you may begin the game with it on the battlefield.
Equipped creature gets +1/+1 and has double strike and trample.
Equip {3} ({3}: Attach to target creature you control. Equip only as a sorcery.)

Morophon, the Boundless

Changeling (This card is every creature type.)
As Morophon, the Boundless enters, choose a creature type.
Spells of the chosen type you cast cost {W}{U}{B}{R}{G} less to cast. This effect reduces only the amount of colored mana you pay.
Other creatures you control of the chosen type get +1/+1.

Leyline of Hope

If Leyline of Hope is in your opening hand, you may begin the game with it on the battlefield.
If you would gain life, you gain that much life plus 1 instead.
As long as you have at least 7 life more than your starting life total, creatures you control get +2/+2.

Bringer of the Red Dawn

You may pay {W}{U}{B}{R}{G} rather than pay this spell's mana cost.
Trample
At the beginning of your upkeep, you may untap target creature and gain control of it until end of turn. That creature gains haste until end of turn.

Leyline of Vitality

If Leyline of Vitality is in your opening hand, you may begin the game with it on the battlefield.
Creatures you control get +0/+1.
Whenever a creature you control enters, you may gain 1 life.

Leyline of the Meek

If Leyline of the Meek is in your opening hand, you may begin the game with it on the battlefield.
Creature tokens get +1/+1.