Izoni, Center of the Web

Menace
Whenever Izoni, Center of the Web enters or attacks, you may collect evidence 4. If you do, create two 2/1 black and green Spider creature tokens with menace and reach.
Sacrifice four tokens: Surveil 2, then draw two cards. You gain 2 life.

Twitching Doll

{T}: Add one mana of any color. Put a nest counter on Twitching Doll.
{T}, Sacrifice Twitching Doll: Create a 2/2 green Spider creature token with reach for each counter on Twitching Doll. Activate only as a sorcery.

Ishkanah, Grafwidow

Reach
Delirium — When Ishkanah, Grafwidow enters, if there are four or more card types among cards in your graveyard, create three 1/2 green Spider creature tokens with reach.
{6}{B}: Target opponent loses 1 life for each Spider you control.

Boxing Ring

Whenever a creature you control enters, it fights up to one target creature you don't control with the same mana value.
{T}: Create a Treasure token. Activate only if you control a creature that fought this turn.

Rotwidow Pack

Reach
{3}{B}{G}, Exile a creature card from your graveyard: Create a 1/2 green Spider creature token with reach, then each opponent loses 1 life for each Spider you control.

Search for Blex

Look at the top five cards of your library. You may put any number of them into your hand and the rest into your graveyard. You lose 3 life for each card you put into your hand this way.

Blex, Vexing Pest

Other Pests, Bats, Insects, Snakes, and Spiders you control get +1/+1.
When Blex, Vexing Pest dies, you gain 4 life.

Blex, Vexing Pest // Search for Blex

Spider Spawning

Create a 1/2 green Spider creature token with reach for each creature card in your graveyard.
Flashback {6}{B} (You may cast this card from your graveyard for its flashback cost. Then exile it.)

Curse of Clinging Webs

Enchant player
Whenever a nontoken creature enchanted player controls dies, exile it and you create a 1/2 green Spider creature token with reach.

Obelisk Spider

Reach
Whenever Obelisk Spider deals combat damage to a creature, put a -1/-1 counter on that creature.
Whenever you put one or more -1/-1 counters on a creature, each opponent loses 1 life and you gain 1 life.

Arasta of the Endless Web

Reach
Whenever an opponent casts an instant or sorcery spell, create a 1/2 green Spider creature token with reach.

Brood Weaver

Reach
When Brood Weaver dies, create a 1/2 green Spider creature token with reach.

Shelob, Child of Ungoliant

Deathtouch, ward {2}
Other Spiders you control have deathtouch and ward {2}.
Whenever another creature dealt damage this turn by a Spider you controlled dies, create a token that's a copy of that creature, except it's a Food artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life," and it loses all other card types.

Penumbra Spider

Reach
When Penumbra Spider dies, create a 2/4 black Spider creature token with reach.

Watcher in the Web

Reach (This creature can block creatures with flying.)
Watcher in the Web can block an additional seven creatures each combat.

Twin-Silk Spider

Reach
When Twin-Silk Spider enters, create a 1/2 green Spider creature token with reach.

Arachnogenesis

Create X 1/2 green Spider creature tokens with reach, where X is the number of creatures attacking you. Prevent all combat damage that would be dealt this turn by non-Spider creatures.

Drider

Reach
Whenever Drider deals combat damage to a player, create a 2/1 black Spider creature token with menace and reach.

Renowned Weaver

{1}{G}, Sacrifice Renowned Weaver: Create a 1/3 green Spider enchantment creature token with reach. (It can block creatures with flying.)