Harsh Mercy

Each player chooses a creature type. Destroy all creatures that aren't of a type chosen this way. They can't be regenerated.

Rukarumel, Biologist

As Rukarumel, Biologist enters, choose a creature type.
Slivers you control and nontoken creatures you control are the chosen type in addition to their other creature types. The same is true for creature spells you control and creature cards you own that aren't on the battlefield.
{3}, {T}: Create a 1/1 colorless Sliver creature token.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.