Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Shizo, Death's Storehouse

{T}: Add {B}.
{B}, {T}: Target legendary creature gains fear until end of turn. (It can't be blocked except by artifact creatures and/or black creatures.)

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Syphon Mind

Each other player discards a card. You draw a card for each card discarded this way.

Noxious Gearhulk

Menace
When Noxious Gearhulk enters the battlefield, you may destroy another target creature. If a creature is destroyed this way, you gain life equal to its toughness.

Nightshade Harvester

Whenever a land enters the battlefield under an opponent's control, that player loses 1 life. Put a +1/+1 counter on Nightshade Harvester.

Emeria, Shattered Skyclave

As Emeria, Shattered Skyclave enters the battlefield, you may pay 3 life. If you don't, it enters the battlefield tapped.
{T}: Add {W}.

Emeria's Call

Create two 4/4 white Angel Warrior creature tokens with flying. Non-Angel creatures you control gain indestructible until your next turn.

Emeria's Call // Emeria, Shattered Skyclave

Read the Bones

Scry 2, then draw two cards. You lose 2 life.

Everflowing Chalice

Multikicker {2} (You may pay an additional {2} any number of times as you cast this spell.)
Everflowing Chalice enters the battlefield with a charge counter on it for each time it was kicked.
{T}: Add {C} for each charge counter on Everflowing Chalice.

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Hall of Heliod's Generosity

{T}: Add {C}.
{1}{W}, {T}: Put target enchantment card from your graveyard on top of your library.

Liesa, Shroud of Dusk

Rather than pay {2} for each previous time you've cast this spell from the command zone this game, pay 2 life that many times.
Flying, lifelink
Whenever a player casts a spell, they lose 2 life.

Erebos, God of the Dead

Indestructible
As long as your devotion to black is less than five, Erebos isn't a creature. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)
Your opponents can't gain life.
{1}{B}, Pay 2 life: Draw a card.

Fabled Passage

{T}, Sacrifice Fabled Passage: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle. Then if you control four or more lands, untap that land.

Fetid Heath

{T}: Add {C}.
{W/B}, {T}: Add {W}{W}, {W}{B}, or {B}{B}.

Kaya's Wrath

Destroy all creatures. You gain life equal to the number of creatures you controlled that were destroyed this way.

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Athreos, God of Passage

Indestructible
As long as your devotion to white and black is less than seven, Athreos isn't a creature.
Whenever another creature you own dies, return it to your hand unless target opponent pays 3 life.

Strip Mine

{T}: Add {C}.
{T}, Sacrifice Strip Mine: Destroy target land.

Day of Judgment

Marsh Flats

{T}, Pay 1 life, Sacrifice Marsh Flats: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters the battlefield, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Sun Titan

Vigilance
Whenever Sun Titan enters the battlefield or attacks, you may return target permanent card with mana value 3 or less from your graveyard to the battlefield.

Polluted Bonds

Whenever a land enters the battlefield under an opponent's control, that player loses 2 life and you gain 2 life.

Orzhov Signet

Hagra Broodpit

Hagra Broodpit enters the battlefield tapped.
{T}: Add {B}.

Hagra Mauling

This spell costs {1} less to cast if an opponent controls no basic lands.
Destroy target creature.

Hagra Mauling // Hagra Broodpit

Wrath of God

Destroy all creatures. They can't be regenerated.

Archangel of Thune

Flying
Lifelink (Damage dealt by this creature also causes you to gain that much life.)
Whenever you gain life, put a +1/+1 counter on each creature you control.

Wayfarer's Bauble

{2}, {T}, Sacrifice Wayfarer's Bauble: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Phyrexian Tower

{T}: Add {C}.
{T}, Sacrifice a creature: Add {B}{B}.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Torment of Hailfire

Repeat the following process X times. Each opponent loses 3 life unless that player sacrifices a nonland permanent or discards a card.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Divinity of Pride

Flying, lifelink
Divinity of Pride gets +4/+4 as long as you have 25 or more life.

Kokusho, the Evening Star

Flying
When Kokusho, the Evening Star dies, each opponent loses 5 life. You gain life equal to the life lost this way.

Ondu Skyruins

Ondu Skyruins enters the battlefield tapped.
{T}: Add {W}.

Ondu Inversion

Ondu Inversion // Ondu Skyruins

Witch of the Moors

Deathtouch
At the beginning of your end step, if you gained life this turn, each opponent sacrifices a creature and you return up to one target creature card from your graveyard to your hand.

Scrubland

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Weathered Wayfarer

{W}, {T}: Search your library for a land card, reveal it, put it into your hand, then shuffle. Activate only if an opponent controls more lands than you.

Wurmcoil Engine

Deathtouch, lifelink
When Wurmcoil Engine dies, create a 3/3 colorless Phyrexian Wurm artifact creature token with deathtouch and a 3/3 colorless Phyrexian Wurm artifact creature token with lifelink.

Godless Shrine

({T}: Add {W} or {B}.)
As Godless Shrine enters the battlefield, you may pay 2 life. If you don't, it enters the battlefield tapped.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Decree of Pain

Destroy all creatures. They can't be regenerated. Draw a card for each creature destroyed this way.
Cycling {3}{B}{B} ({3}{B}{B}, Discard this card: Draw a card.)
When you cycle Decree of Pain, all creatures get -2/-2 until end of turn.

Prismatic Vista

{T}, Pay 1 life, Sacrifice Prismatic Vista: Search your library for a basic land card, put it onto the battlefield, then shuffle.

Tragic Arrogance

For each player, you choose from among the permanents that player controls an artifact, a creature, an enchantment, and a planeswalker. Then each player sacrifices all other nonland permanents they control.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

High Market

{T}: Add {C}.
{T}, Sacrifice a creature: You gain 1 life.

Agadeem, the Undercrypt

As Agadeem, the Undercrypt enters the battlefield, you may pay 3 life. If you don't, it enters the battlefield tapped.
{T}: Add {B}.

Agadeem's Awakening

Return from your graveyard to the battlefield any number of target creature cards that each have a different mana value X or less.

Agadeem's Awakening // Agadeem, the Undercrypt

Plains

Gilded Lotus

Revenge

Double your life total. Target opponent loses half their life, rounded up.

Revival

Return target creature card with mana value 3 or less from your graveyard to the battlefield.

Revival // Revenge

Hour of Revelation

This spell costs {3} less to cast if there are ten or more nonland permanents on the battlefield.
Destroy all nonland permanents.

Swamp

Ancient Tomb

{T}: Add {C}{C}. Ancient Tomb deals 2 damage to you.

Volrath's Stronghold

{T}: Add {C}.
{1}{B}, {T}: Put target creature card from your graveyard on top of your library.

Night's Whisper

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Vault of the Archangel

{T}: Add {C}.
{2}{W}{B}, {T}: Creatures you control gain deathtouch and lifelink until end of turn.

Sign in Blood

Target player draws two cards and loses 2 life.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Sol Ring

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Bojuka Bog

Bojuka Bog enters the battlefield tapped.
When Bojuka Bog enters the battlefield, exile target player's graveyard.
{T}: Add {B}.

Mana Crypt

At the beginning of your upkeep, flip a coin. If you lose the flip, Mana Crypt deals 3 damage to you.
{T}: Add {C}{C}.

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. Caves of Koilos deals 1 damage to you.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Land Tax

At the beginning of your upkeep, if an opponent controls more lands than you, you may search your library for up to three basic land cards, reveal them, put them into your hand, then shuffle.

Twilight Prophet

Flying
Ascend (If you control ten or more permanents, you get the city's blessing for the rest of the game.)
At the beginning of your upkeep, if you have the city's blessing, reveal the top card of your library and put it into your hand. Each opponent loses X life and you gain X life, where X is that card's mana value.

Knight of the White Orchid

First strike
When Knight of the White Orchid enters the battlefield, if an opponent controls more lands than you, you may search your library for a Plains card, put it onto the battlefield, then shuffle.

Spires of Orazca

(Transforms from Thaumatic Compass.)
{T}: Add {C}.
{T}: Untap target attacking creature an opponent controls and remove it from combat.

Thaumatic Compass

{3}, {T}: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.
At the beginning of your end step, if you control seven or more lands, transform Thaumatic Compass.

Thaumatic Compass // Spires of Orazca

Bloodchief Ascension

At the beginning of each end step, if an opponent lost 2 or more life this turn, you may put a quest counter on Bloodchief Ascension. (Damage causes loss of life.)
Whenever a card is put into an opponent's graveyard from anywhere, if Bloodchief Ascension has three or more quest counters on it, you may have that player lose 2 life. If you do, you gain 2 life.

Serra Ascendant

Lifelink (Damage dealt by this creature also causes you to gain that much life.)
As long as you have 30 or more life, Serra Ascendant gets +5/+5 and has flying.

Skyclave Relic

Kicker {3}
Indestructible
When Skyclave Relic enters the battlefield, if it was kicked, create two tapped tokens that are copies of Skyclave Relic.
{T}: Add one mana of any color.

Castle Locthwain

Castle Locthwain enters the battlefield tapped unless you control a Swamp.
{T}: Add {B}.
{1}{B}{B}, {T}: Draw a card, then you lose life equal to the number of cards in your hand.

Nihil Spellbomb

{T}, Sacrifice Nihil Spellbomb: Exile target player's graveyard.
When Nihil Spellbomb is put into a graveyard from the battlefield, you may pay {B}. If you do, draw a card.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Despark

Exile target permanent with mana value 4 or greater.

Demonic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Umezawa's Jitte

Whenever equipped creature deals combat damage, put two charge counters on Umezawa's Jitte.
Remove a charge counter from Umezawa's Jitte: Choose one —
• Equipped creature gets +2/+2 until end of turn.
• Target creature gets -1/-1 until end of turn.
• You gain 2 life.
Equip {2}

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice Silent Clearing: Draw a card.

Doom Whisperer

Flying, trample
Pay 2 life: Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)