Kaervek the Merciless

Whenever an opponent casts a spell, Kaervek the Merciless deals damage equal to that spell's mana value to any target.

Aven Interrupter

Flash
Flying
When Aven Interrupter enters, exile target spell. It becomes plotted. (Its owner may cast it as a sorcery on a later turn without paying its mana cost.)
Spells your opponents cast from graveyards or from exile cost {2} more to cast.

Cindervines

Whenever an opponent casts a noncreature spell, Cindervines deals 1 damage to that player.
{1}, Sacrifice Cindervines: Destroy target artifact or enchantment. Cindervines deals 2 damage to that permanent's controller.

Managorger Hydra

Trample
Whenever a player casts a spell, put a +1/+1 counter on Managorger Hydra.

Ishai, Ojutai Dragonspeaker

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Ishai, Ojutai Dragonspeaker.
Partner (You can have two commanders if both have partner.)

Esper Sentinel

Whenever an opponent casts their first noncreature spell each turn, draw a card unless that player pays {X}, where X is Esper Sentinel's power.

Sauron, the Dark Lord

Ward—Sacrifice a legendary artifact or legendary creature.
Whenever an opponent casts a spell, amass Orcs 1.
Whenever an Army you control deals combat damage to a player, the Ring tempts you.
Whenever the Ring tempts you, you may discard your hand. If you do, draw four cards.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Thundering Mightmare

Soulbond (You may pair this creature with another unpaired creature when either enters. They remain paired for as long as you control both of them.)
As long as Thundering Mightmare is paired with another creature, each of those creatures has "Whenever an opponent casts a spell, put a +1/+1 counter on this creature."

Arasta of the Endless Web

Reach
Whenever an opponent casts an instant or sorcery spell, create a 1/2 green Spider creature token with reach.

Rhystic Study

Whenever an opponent casts a spell, you may draw a card unless that player pays {1}.

Shadow in the Warp

The first creature spell you cast each turn costs {2} less to cast.
Whenever an opponent casts their first noncreature spell each turn, Shadow in the Warp deals 2 damage to that player.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Ghostly Pilferer

Whenever Ghostly Pilferer becomes untapped, you may pay {2}. If you do, draw a card.
Whenever an opponent casts a spell from anywhere other than their hand, draw a card.
Discard a card: Ghostly Pilferer can't be blocked this turn.

Mangara, the Diplomat

Lifelink
Whenever an opponent attacks with creatures, if two or more of those creatures are attacking you and/or planeswalkers you control, draw a card.
Whenever an opponent casts their second spell each turn, draw a card.

Monologue Tax

Whenever an opponent casts their second spell each turn, you create a Treasure token.

Lurking Predators

Whenever an opponent casts a spell, reveal the top card of your library. If it's a creature card, put it onto the battlefield. Otherwise, you may put that card on the bottom of your library.

Isolation Cell

Whenever an opponent casts a creature spell, that player loses 2 life unless they pay {2}.

Explore the Vastlands

Each player looks at the top five cards of their library and may reveal a land card and/or an instant or sorcery card from among them. Each player puts the cards they revealed this way into their hand and the rest on the bottom of their library in a random order. Each player gains 3 life.

Wandering Archaic

Whenever an opponent casts an instant or sorcery spell, they may pay {2}. If they don't, you may copy that spell. You may choose new targets for the copy.

Wandering Archaic // Explore the Vastlands

Scab-Clan Berserker

Haste
Renown 1 (When this creature deals combat damage to a player, if it isn't renowned, put a +1/+1 counter on it and it becomes renowned.)
Whenever an opponent casts a noncreature spell, if Scab-Clan Berserker is renowned, Scab-Clan Berserker deals 2 damage to that player.

Howling Moon

At the beginning of combat on your turn, target Wolf or Werewolf you control gets +2/+2 until end of turn.
Whenever an opponent casts their second spell each turn, create a 2/2 green Wolf creature token.

Nezahal, Primal Tide

This spell can't be countered.
You have no maximum hand size.
Whenever an opponent casts a noncreature spell, draw a card.
Discard three cards: Exile Nezahal, Primal Tide. Return it to the battlefield tapped under its owner's control at the beginning of the next end step.

Jin-Gitaxias, Progress Tyrant

Whenever you cast an artifact, instant, or sorcery spell, copy that spell. You may choose new targets for the copy. This ability triggers only once each turn. (A copy of a permanent spell becomes a token.)
Whenever an opponent casts an artifact, instant, or sorcery spell, counter that spell. This ability triggers only once each turn.

Dragonlair Spider

Reach
Whenever an opponent casts a spell, create a 1/1 green Insect creature token.

Insight

Whenever an opponent casts a green spell, you draw a card.

Pollywog Prodigy

Evolve (Whenever a creature you control enters, if that creature has greater power or toughness than this creature, put a +1/+1 counter on this creature.)
Whenever an opponent casts a noncreature spell with mana value less than Pollywog Prodigy's power, draw a card.

Tana, the Bloodsower

Trample
Whenever Tana, the Bloodsower deals combat damage to a player, create that many 1/1 green Saproling creature tokens.
Partner (You can have two commanders if both have partner.)

Taurean Mauler

Changeling (This card is every creature type.)
Whenever an opponent casts a spell, you may put a +1/+1 counter on this creature.

Hunting Grounds

Threshold — As long as seven or more cards are in your graveyard, Hunting Grounds has "Whenever an opponent casts a spell, you may put a creature card from your hand onto the battlefield."

Trouble in Pairs

If an opponent would begin an extra turn, that player skips that turn instead.
Whenever an opponent attacks you with two or more creatures, draws their second card each turn, or casts their second spell each turn, you draw a card.

Steelburr Champion

Offspring {1}{W} (You may pay an additional {1}{W} as you cast this spell. If you do, when this creature enters, create a 1/1 token copy of it.)
Vigilance
Whenever an opponent casts a noncreature spell, put a +1/+1 counter on this creature.

Soul Partition

Exile target nonland permanent. For as long as that card remains exiled, its owner may play it. A spell cast by an opponent this way costs {2} more to cast.

Predatory Hunger

Enchant creature
Whenever an opponent casts a creature spell, put a +1/+1 counter on enchanted creature.

Steam Clean

Return target nonland permanent to its owner's hand. (Then exile this card. You may cast the creature later from exile.)

Scalding Viper

Whenever an opponent casts a spell with mana value 3 or less, Scalding Viper deals 1 damage to that player.

Scalding Viper // Steam Clean

Mind's Dilation

Whenever an opponent casts their first spell each turn, that player exiles the top card of their library. If it's a nonland card, you may cast it without paying its mana cost.

Forgotten Ancient

Whenever a player casts a spell, you may put a +1/+1 counter on Forgotten Ancient.
At the beginning of your upkeep, you may move any number of +1/+1 counters from Forgotten Ancient onto other creatures.

Aerial Extortionist

Flying
Whenever Aerial Extortionist enters or deals combat damage to a player, exile up to one target nonland permanent. For as long as that card remains exiled, its owner may cast it.
Whenever another player casts a spell from anywhere other than their hand, draw a card.