Laboratory Maniac

If you would draw a card while your library has no cards in it, you win the game instead.

Sands of Delirium

Toxrill, the Corrosive

At the beginning of each end step, put a slime counter on each creature you don't control.
Creatures you don't control get -1/-1 for each slime counter on them.
Whenever a creature you don't control with a slime counter on it dies, create a 1/1 black Slug creature token.
{U}{B}, Sacrifice a Slug: Draw a card.

Sheoldred, Whispering One

Swampwalk (This creature can't be blocked as long as defending player controls a Swamp.)
At the beginning of your upkeep, return target creature card from your graveyard to the battlefield.
At the beginning of each opponent's upkeep, that player sacrifices a creature of their choice.

Phyrexian Obliterator

Trample
Whenever a source deals damage to this creature, that source's controller sacrifices that many permanents of their choice.

Doomsday Confluence

Choose X. You may choose the same mode more than once.
• Each player sacrifices a nonartifact creature of their choice.
• Create a 3/3 black Dalek artifact creature token with menace.
• Each opponent discards a card.

Appetite for Brains

Target opponent reveals their hand. You choose a card from it with mana value 4 or greater and exile that card.

Priest of Forgotten Gods

{T}, Sacrifice two other creatures: Any number of target players each lose 2 life and sacrifice a creature of their choice. You add {B}{B} and draw a card.

Innocent Blood

Each player sacrifices a creature of their choice.

Fleshbag Marauder

When this creature enters, each player sacrifices a creature of their choice.

Szat's Will

Choose one. If you control a commander as you cast this spell, you may choose both instead.
• Each opponent sacrifices a creature they control with the greatest power.
• Exile all opponents' graveyards, then create X 0/1 black Thrull creature tokens, where X is the greatest power among creature cards exiled this way.

Plaguecrafter

When this creature enters, each player sacrifices a creature or planeswalker of their choice. Each player who can't discards a card.

Damnation

Destroy all creatures. They can't be regenerated.

Sadistic Sacrament

Kicker {7} (You may pay an additional {7} as you cast this spell.)
Search target player's library for up to three cards, exile them, then that player shuffles. If this spell was kicked, instead search that player's library for up to fifteen cards, exile them, then that player shuffles.

Cryptbreaker

{1}{B}, {T}, Discard a card: Create a 2/2 black Zombie creature token.
Tap three untapped Zombies you control: You draw a card and you lose 1 life.

Gate to Phyrexia

Sacrifice a creature: Destroy target artifact. Activate only during your upkeep and only once each turn.

Zombie Infestation

Discard two cards: Create a 2/2 black Zombie creature token.

Severed Strands

As an additional cost to cast this spell, sacrifice a creature.
You gain life equal to the sacrificed creature's toughness. Destroy target creature an opponent controls.