Demogorgon's Clutches

Target opponent discards two cards, mills two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Eldritch Pact

Target player draws X cards and loses X life, where X is the number of cards in their graveyard.

Costly Plunder

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards.

Sign in Blood

Target player draws two cards and loses 2 life.

Damnable Pact

Target player draws X cards and loses X life.

Funeral Rites

You draw two cards, lose 2 life, then mill two cards.

Bad Deal

You draw two cards and each opponent discards two cards. Each player loses 2 life.

Clockwork Fox

When Clockwork Fox leaves the battlefield, you draw two cards and each opponent draws a card.

Ob Nixilis of the Black Oath

+2: Each opponent loses 1 life. You gain life equal to the life lost this way.
−2: Create a 5/5 black Demon creature token with flying. You lose 2 life.
−8: You get an emblem with "{1}{B}, Sacrifice a creature: You gain X life and draw X cards, where X is the sacrificed creature's power."
Ob Nixilis of the Black Oath can be your commander.

Burnished Hart

{3}, Sacrifice this creature: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Consume Spirit

Spend only black mana on X.
Consume Spirit deals X damage to any target and you gain X life.

Painful Lesson

Eldrazi Devastator

Geier Reach Sanitarium

{T}: Add {C}.
{2}, {T}: Each player draws a card, then discards a card.

Ancient Craving

You draw three cards and you lose 3 life.

Alms of the Vein

Target opponent loses 3 life and you gain 3 life.
Madness {B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Nightmarish End

Target creature gets -X/-X until end of turn, where X is the number of cards in your hand.

Davriel's Shadowfugue

Target player discards two cards and loses 2 life.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Blood Tithe

Each opponent loses 3 life. You gain life equal to the life lost this way.

Ulamog's Crusher

Annihilator 2 (Whenever this creature attacks, defending player sacrifices two permanents of their choice.)
Ulamog's Crusher attacks each combat if able.

Reckoner's Bargain

As an additional cost to cast this spell, sacrifice an artifact or creature.
You gain life equal to the sacrificed permanent's mana value. Draw two cards.

Sorin's Thirst

Sorin's Thirst deals 2 damage to target creature and you gain 2 life.

Demon's Due

Scry 2, then draw two cards. You lose 2 life.

Essence Drain

Essence Drain deals 3 damage to any target and you gain 3 life.

Murder

Desolation Twin

When you cast this spell, create a 10/10 colorless Eldrazi creature token.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Ob Nixilis Reignited

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Last Kiss

Last Kiss deals 2 damage to target creature and you gain 2 life.

Caress of Phyrexia

Target player draws three cards, loses 3 life, and gets three poison counters.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Filigree Familiar

When Filigree Familiar enters, you gain 2 life.
When Filigree Familiar dies, draw a card.

Grave Titan

Deathtouch
Whenever Grave Titan enters or attacks, create two 2/2 black Zombie creature tokens.

Foreboding Fruit

Target player draws two cards and loses 2 life.
Adamant — If at least three black mana was spent to cast this spell, create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Skeletal Scrying

As an additional cost to cast this spell, exile X cards from your graveyard.
You draw X cards and you lose X life.

Succumb to Temptation

Mirrodin Avenged

Destroy target creature that was dealt damage this turn.
Draw a card.

Drain Life

Spend only black mana on X.
Drain Life deals X damage to any target. You gain life equal to the damage dealt, but not more life than the player's life total before the damage was dealt, the planeswalker's loyalty before the damage was dealt, or the creature's toughness.

Creeping Chill

Creeping Chill deals 3 damage to each opponent and you gain 3 life.
When Creeping Chill is put into your graveyard from your library, you may exile it. If you do, Creeping Chill deals 3 damage to each opponent and you gain 3 life.

Atrocious Experiment

Target player mills two cards, draws two cards, and loses 2 life. (To mill a card, a player puts the top card of their library into their graveyard.)

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Sol Ring

Greed

Moment of Craving

Target creature gets -2/-2 until end of turn. You gain 2 life.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Ob Nixilis, the Hate-Twisted

Whenever an opponent draws a card, Ob Nixilis, the Hate-Twisted deals 1 damage to that player.
−2: Destroy target creature. Its controller draws two cards.

Pathrazer of Ulamog

Annihilator 3 (Whenever this creature attacks, defending player sacrifices three permanents of their choice.)
Pathrazer of Ulamog can't be blocked except by three or more creatures.

Thought Vessel

You have no maximum hand size.
{T}: Add {C}.

Solemn Simulacrum

When this creature enters, you may search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.
When this creature dies, you may draw a card.

Swamp

Dark Ritual

Palladium Myr

Well of Lost Dreams

Whenever you gain life, you may pay {X}, where X is less than or equal to the amount of life you gained. If you do, draw X cards.

Feed the Infection

You draw three cards and you lose 3 life.
Corrupted — Each opponent who has three or more poison counters loses 3 life.

Dreadhorde Invasion

At the beginning of your upkeep, you lose 1 life and amass Zombies 1. (Put a +1/+1 counter on an Army you control. It's also a Zombie. If you don't control an Army, create a 0/0 black Zombie Army creature token first.)
Whenever a Zombie token you control with power 6 or greater attacks, it gains lifelink until end of turn.

Underworld Dreams

Whenever an opponent draws a card, Underworld Dreams deals 1 damage to that player.

Reliquary Tower

Crushing Disappointment

Each player loses 2 life. You draw two cards.

Gray Merchant of Asphodel

When Gray Merchant of Asphodel enters, each opponent loses X life, where X is your devotion to black. You gain life equal to the life lost this way. (Each {B} in the mana costs of permanents you control counts toward your devotion to black.)

Sheoldred, the Apocalypse

Deathtouch
Whenever you draw a card, you gain 2 life.
Whenever an opponent draws a card, they lose 2 life.

Certain Death

Destroy target creature. Its controller loses 2 life and you gain 2 life.

You Are Already Dead

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Psychosis Crawler

Psychosis Crawler's power and toughness are each equal to the number of cards in your hand.
Whenever you draw a card, each opponent loses 1 life.