Hero's Downfall

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Praetor's Grasp

Search target opponent's library for a card and exile it face down. Then that player shuffles. You may play that card for as long as it remains exiled.

Bontu's Monument

Black creature spells you cast cost {1} less to cast.
Whenever you cast a creature spell, each opponent loses 1 life and you gain 1 life.

Master of the Feast

Flying
At the beginning of your upkeep, each opponent draws a card.

Teferi's Puzzle Box

At the beginning of each player's draw step, that player puts the cards in their hand on the bottom of their library in any order, then draws that many cards.

Offer Immortality

Target creature gains deathtouch and indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Gix, Yawgmoth Praetor

Whenever a creature deals combat damage to one of your opponents, its controller may pay 1 life. If they do, they draw a card.
{4}{B}{B}{B}, Discard X cards: Exile the top X cards of target opponent's library. You may play lands and cast spells from among cards exiled this way without paying their mana costs.

Marauding Blight-Priest

Whenever you gain life, each opponent loses 1 life.

Vraska's Fall

Each opponent sacrifices a creature or planeswalker of their choice and gets a poison counter.

Sol Ring

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.

Hedron Archive

{T}: Add {C}{C}.
{2}, {T}, Sacrifice this artifact: Draw two cards.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Murder

Painful Quandary

Whenever an opponent casts a spell, that player loses 5 life unless they discard a card.

Sheoldred's Edict

Choose one —
• Each opponent sacrifices a nontoken creature of their choice.
• Each opponent sacrifices a creature token of their choice.
• Each opponent sacrifices a planeswalker of their choice.

Bloodgift Demon

Flying
At the beginning of your upkeep, target player draws a card and loses 1 life.

The Cruelty of Gix

Read ahead (Choose a chapter and start with that many lore counters. Add one after your draw step. Skipped chapters don't trigger. Sacrifice after III.)
I — Target opponent reveals their hand. You choose a creature or planeswalker card from it. That player discards that card.
II — Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.
III — Put target creature card from a graveyard onto the battlefield under your control.

Go for the Throat

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Zenith Chronicler

Whenever a player casts their first multicolored spell each turn, each other player draws a card.

Insatiable Avarice

Spree (Choose one or more additional costs.)
+ {2} — Search your library for a card, then shuffle and put that card on top.
+ {B}{B} — Target player draws three cards and loses 3 life.

No Mercy

Whenever a creature deals damage to you, destroy it.

Fate Unraveler

Whenever an opponent draws a card, this creature deals 1 damage to that player.

Rankle, Master of Pranks

Flying, haste
Whenever Rankle deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature of their choice.

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Swamp

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Burnished Hart

{3}, Sacrifice this creature: Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle.

Painful Lesson

Target player draws two cards and loses 2 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Swiftfoot Boots

Equipped creature has hexproof and haste. (It can't be the target of spells or abilities your opponents control. It can attack and {T} no matter when it came under your control.)
Equip {1} ({1}: Attach to target creature you control. Equip only as a sorcery.)

Deadly Dispute

As an additional cost to cast this spell, sacrifice an artifact or creature.
Draw two cards and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Baleful Mastery

You may pay {1}{B} rather than pay this spell's mana cost.
If the {1}{B} cost was paid, an opponent draws a card.
Exile target creature or planeswalker.

Profane Tutor

Suspend 2—{1}{B} (Rather than cast this card from your hand, pay {1}{B} and exile it with two time counters on it. At the beginning of your upkeep, remove a time counter. When the last is removed, you may cast it without paying its mana cost.)
Search your library for a card, put that card into your hand, then shuffle.

Howling Golem

Whenever this creature attacks or blocks, each player draws a card.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Sign in Blood

Jet Medallion

Black spells you cast cost {1} less to cast.

Horn of Greed

Whenever a player plays a land, that player draws a card.

Diabolic Intent

As an additional cost to cast this spell, sacrifice a creature.
Search your library for a card, put that card into your hand, then shuffle.

Dread Presence

Whenever a Swamp you control enters, choose one —
• You draw a card and you lose 1 life.
• This creature deals 2 damage to any target and you gain 2 life.

Sudden Spoiling

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Until end of turn, creatures target player controls lose all abilities and have base power and toughness 0/2.