Search for Blex

Look at the top five cards of your library. You may put any number of them into your hand and the rest into your graveyard. You lose 3 life for each card you put into your hand this way.

Blex, Vexing Pest

Other Pests, Bats, Insects, Snakes, and Spiders you control get +1/+1.
When Blex, Vexing Pest dies, you gain 4 life.

Blex, Vexing Pest // Search for Blex

Have

Golgari Signet

Arachnus Web

Enchant creature
Enchanted creature can't attack or block, and its activated abilities can't be activated.
At the beginning of the end step, if enchanted creature's power is 4 or greater, destroy Arachnus Web.

Command Tower

{T}: Add one mana of any color in your commander's color identity.

Heroic Intervention

Permanents you control gain hexproof and indestructible until end of turn.

Arasta of the Endless Web

Reach
Whenever an opponent casts an instant or sorcery spell, create a 1/2 green Spider creature token with reach.

Talisman of Resilience

{T}: Add {C}.
{T}: Add {B} or {G}. Talisman of Resilience deals 1 damage to you.

Shelob, Child of Ungoliant

Deathtouch, ward {2}
Other Spiders you control have deathtouch and ward {2}.
Whenever another creature dealt damage this turn by a Spider you controlled dies, create a token that's a copy of that creature, except it's a Food artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life," and it loses all other card types.

Lolth, Spider Queen

Whenever a creature you control dies, put a loyalty counter on Lolth, Spider Queen.
0: You draw a card and you lose 1 life.
−3: Create two 2/1 black Spider creature tokens with menace and reach.
−8: You get an emblem with "Whenever an opponent is dealt combat damage by one or more creatures you control, if that player lost less than 8 life this turn, they lose life equal to the difference."

Curse of Clinging Webs

Enchant player
Whenever a nontoken creature enchanted player controls dies, exile it and you create a 1/2 green Spider creature token with reach.

Abundance

If you would draw a card, you may instead choose land or nonland and reveal cards from the top of your library until you reveal a card of the chosen kind. Put that card into your hand and put all other cards revealed this way on the bottom of your library in any order.

Shelob, Dread Weaver

Whenever a nontoken creature an opponent controls dies, exile it.
{2}{B}, Put a creature card exiled with Shelob, Dread Weaver into its owner's graveyard: Put two +1/+1 counters on Shelob. Draw a card.
{X}{1}{B}: Put target creature card with mana value X exiled with Shelob onto the battlefield tapped under your control.

Delighted Halfling

{T}: Add {C}.
{T}: Add one mana of any color. Spend this mana only to cast a legendary spell, and that spell can't be countered.

Sol Ring

Ishkanah, Grafwidow

Reach
Delirium — When Ishkanah, Grafwidow enters, if there are four or more card types among cards in your graveyard, create three 1/2 green Spider creature tokens with reach.
{6}{B}: Target opponent loses 1 life for each Spider you control.

Bojuka Bog

Bojuka Bog enters tapped.
When Bojuka Bog enters, exile target player's graveyard.
{T}: Add {B}.

Three Visits

Search your library for a Forest card, put it onto the battlefield, then shuffle.

Akroma's Memorial

Creatures you control have flying, first strike, vigilance, trample, haste, and protection from black and from red.

Deadly Rollick

If you control a commander, you may cast this spell without paying its mana cost.
Exile target creature.

Arcane Signet

Shelob's Ambush

Target creature gets +1/+2 and gains deathtouch until end of turn. Create a Food token. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

Tower Winder

Reach, deathtouch
When Tower Winder enters, search your library and/or graveyard for a card named Command Tower, reveal it, and put it into your hand. If you search your library this way, shuffle.

Nature's Lore

Search your library for a Forest card, put that card onto the battlefield, then shuffle.

Birds of Paradise

Arachnogenesis

Create X 1/2 green Spider creature tokens with reach, where X is the number of creatures attacking you. Prevent all combat damage that would be dealt this turn by non-Spider creatures.

Chainweb Aracnir

Reach
When Chainweb Aracnir enters, it deals damage equal to its power to target creature with flying an opponent controls.
Escape—{3}{G}{G}, Exile four other cards from your graveyard. (You may cast this card from your graveyard for its escape cost.)
Chainweb Aracnir escapes with three +1/+1 counters on it.

Arachnoform

Enchant creature
Enchanted creature gets +2/+2, has reach, and is every creature type.

Golgari Charm

Choose one —
• All creatures get -1/-1 until end of turn.
• Destroy target enchantment.
• Regenerate each creature you control.

Silklash Spider

Reach
{X}{G}{G}: Silklash Spider deals X damage to each creature with flying.

Obscuring Haze

If you control a commander, you may cast this spell without paying its mana cost.
Prevent all damage that would be dealt this turn by creatures your opponents control.

Cultivator Colossus

Trample
Cultivator Colossus's power and toughness are each equal to the number of lands you control.
When Cultivator Colossus enters, you may put a land card from your hand onto the battlefield tapped. If you do, draw a card and repeat this process.

Cultivate

Search your library for up to two basic land cards, reveal those cards, put one onto the battlefield tapped and the other into your hand, then shuffle.

Arachnus Spinner

Reach
Tap an untapped Spider you control: Search your graveyard and/or library for a card named Arachnus Web and put it onto the battlefield attached to target creature. If you search your library this way, shuffle.

Entish Restoration

Sacrifice a land. Search your library for up to two basic land cards, put them onto the battlefield tapped, then shuffle. If you control a creature with power 4 or greater, instead search your library for up to three basic land cards, put them onto the battlefield tapped, then shuffle.

Triumph of the Hordes

Until end of turn, creatures you control get +1/+1 and gain trample and infect. (Creatures with infect deal damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.)

Drider

Reach
Whenever Drider deals combat damage to a player, create a 2/1 black Spider creature token with menace and reach.

Peregrin Took

If one or more tokens would be created under your control, those tokens plus an additional Food token are created instead. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")
Sacrifice three Foods: Draw a card.

Constant Mists

Buyback—Sacrifice a land. (You may sacrifice a land in addition to any other costs as you cast this spell. If you do, put this card into your hand as it resolves.)
Prevent all combat damage that would be dealt this turn.

Rampant Growth

Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.