Bloodletter of Aclazotz

Flying
If an opponent would lose life during your turn, they lose twice that much life instead. (Damage causes loss of life.)

Magus of the Mirror

{T}, Sacrifice this creature: Exchange life totals with target opponent. Activate only during your upkeep.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Vizkopa Guildmage

{1}{W}{B}: Target creature gains lifelink until end of turn.
{1}{W}{B}: Whenever you gain life this turn, each opponent loses that much life.

Near-Death Experience

At the beginning of your upkeep, if you have exactly 1 life, you win the game.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik.

Teferi's Protection

Until your next turn, your life total can't change and you gain protection from everything. All permanents you control phase out. (While they're phased out, they're treated as though they don't exist. They phase in before you untap during your untap step.)
Exile Teferi's Protection.

Evolving Wilds

{T}, Sacrifice this land: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Oketra's Last Mercy

Your life total becomes equal to your starting life total. Lands you control don't untap during your next untap step.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Wayfarer's Bauble

{2}, {T}, Sacrifice this artifact: Search your library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Resolute Archangel

Flying
When this creature enters, if your life total is less than your starting life total, it becomes equal to your starting life total.

Vito, Thorn of the Dusk Rose

Whenever you gain life, target opponent loses that much life.
{3}{B}{B}: Creatures you control gain lifelink until end of turn.

Sudden Spoiling

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
Until end of turn, creatures target player controls lose all abilities and have base power and toughness 0/2.

Swamp

Angel's Grace

Split second (As long as this spell is on the stack, players can't cast spells or activate abilities that aren't mana abilities.)
You can't lose the game this turn and your opponents can't win the game this turn. Until end of turn, damage that would reduce your life total to less than 1 reduces it to 1 instead.

Crypt Ghast

Extort (Whenever you cast a spell, you may pay {W/B}. If you do, each opponent loses 1 life and you gain that much life.)
Whenever you tap a Swamp for mana, add an additional {B}.

Isolated Chapel

This land enters tapped unless you control a Plains or a Swamp.
{T}: Add {W} or {B}.

Bojuka Bog

This land enters tapped.
When this land enters, exile target player's graveyard.
{T}: Add {B}.

Phyrexian Arena

At the beginning of your upkeep, you draw a card and you lose 1 life.

Godless Shrine

({T}: Add {W} or {B}.)
As this land enters, you may pay 2 life. If you don't, it enters tapped.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. This artifact deals 1 damage to you.

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Lotho, Corrupt Shirriff

Whenever a player casts their second spell each turn, you lose 1 life and create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Exsanguinate

Each opponent loses X life. You gain life equal to the life lost this way.

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Silence

Your opponents can't cast spells this turn.

Night's Whisper

Grand Abolisher

During your turn, your opponents can't cast spells or activate abilities of artifacts, creatures, or enchantments.

Hatred

As an additional cost to cast this spell, pay X life.
Target creature gets +X/+0 until end of turn.

Reliquary Tower

You have no maximum hand size.
{T}: Add {C}.

Reverse the Sands

Redistribute any number of players' life totals. (Each of those players gets one life total back.)

Tainted Sigil

{T}, Sacrifice this artifact: You gain life equal to the total life lost by all players this turn. (Damage causes loss of life.)

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Necropotence

Skip your draw step.
Whenever you discard a card, exile that card from your graveyard.
Pay 1 life: Exile the top card of your library face down. Put that card into your hand at the beginning of your next end step.

Generous Gift

Destroy target permanent. Its controller creates a 3/3 green Elephant creature token.

Axis of Mortality

At the beginning of your upkeep, you may have two target players exchange life totals.

Angelic Enforcer

Flying
You have hexproof.
Angelic Enforcer's power and toughness are each equal to your life total.
Whenever this creature attacks, double your life total.

Enduring Angel

Flying, double strike
You have hexproof.
If your life total would be reduced to 0 or less, instead transform this creature and your life total becomes 3. Then if this creature didn't transform this way, you lose the game.

Enduring Angel // Angelic Enforcer

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Marsh Flats

{T}, Pay 1 life, Sacrifice this land: Search your library for a Plains or Swamp card, put it onto the battlefield, then shuffle.

Read the Bones

Scry 2, then draw two cards. You lose 2 life. (To scry 2, look at the top two cards of your library, then put any number of them on the bottom and the rest on top in any order.)

Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Exquisite Archangel

Flying
If you would lose the game, instead exile this creature and your life total becomes equal to your starting life total.

Smothering Tithe

Whenever an opponent draws a card, that player may pay {2}. If the player doesn't, you create a Treasure token. (It's an artifact with "{T}, Sacrifice this token: Add one mana of any color.")

Urborg, Tomb of Yawgmoth

Each land is a Swamp in addition to its other land types.

Selenia, Dark Angel

Flying
Pay 2 life: Return Selenia to its owner's hand.

Silent Clearing

{T}, Pay 1 life: Add {W} or {B}.
{1}, {T}, Sacrifice this land: Draw a card.

Sign in Blood

Target player draws two cards and loses 2 life.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Kambal, Consul of Allocation

Whenever an opponent casts a noncreature spell, that player loses 2 life and you gain 2 life.

Witch-Blessed Meadow

As this land enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {W}.

Witch Enchanter

When this creature enters, destroy target artifact or enchantment an opponent controls.

Witch Enchanter // Witch-Blessed Meadow

Tainted Field

{T}: Add {C}.
{T}: Add {W} or {B}. Activate only if you control a Swamp.

Weathered Wayfarer

{W}, {T}: Search your library for a land card, reveal it, put it into your hand, then shuffle. Activate only if an opponent controls more lands than you.

Plains

Font of Agonies

Whenever you pay life, put that many blood counters on this enchantment.
{1}{B}, Remove four blood counters from this enchantment: Destroy target creature.

Exquisite Blood

Whenever an opponent loses life, you gain that much life.

Enlightened Tutor

Search your library for an artifact or enchantment card, reveal it, then shuffle and put that card on top.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Sol Ring

Farewell

Choose one or more —
• Exile all artifacts.
• Exile all creatures.
• Exile all enchantments.
• Exile all graveyards.

Tainted Remedy

If an opponent would gain life, that player loses that much life instead.

Utter End

Orzhov Signet

Children of Korlis

Sacrifice this creature: You gain life equal to the life you've lost this turn. (Damage causes loss of life.)

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Anguished Unmaking

Exile target nonland permanent. You lose 3 life.

Greed

Courageous Resolve

Up to one target creature you control gains protection from each of your opponents until end of turn. Draw a card. (It can't be blocked, targeted, dealt damage, enchanted, or equipped by anything controlled by those players.)
Fateful hour — If you have 5 or less life, you can't lose life this turn, you can't lose the game this turn, and your opponents can't win the game this turn.

Debt to the Deathless

Each opponent loses two times X life. You gain life equal to the life lost this way.

Thought Vessel

Bolas's Citadel

You may look at the top card of your library any time.
You may play lands and cast spells from the top of your library. If you cast a spell this way, pay life equal to its mana value rather than pay its mana cost.
{T}, Sacrifice ten nonland permanents: Each opponent loses 10 life.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Black Market

Whenever a creature dies, put a charge counter on this enchantment.
At the beginning of your first main phase, add {B} for each charge counter on this enchantment.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Shattered Sanctum

This land enters tapped unless you control two or more other lands.
{T}: Add {W} or {B}.

Despark

Exile target permanent with mana value 4 or greater.

Diabolic Tutor

Search your library for a card, put that card into your hand, then shuffle.

Triskaidekaphobia

At the beginning of your upkeep, choose one —
• Each player with exactly 13 life loses the game, then each player gains 1 life.
• Each player with exactly 13 life loses the game, then each player loses 1 life.

Demonic Tutor

Dark Ritual

Command Tower

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Terramorphic Expanse

Caves of Koilos

{T}: Add {C}.
{T}: Add {W} or {B}. This land deals 1 damage to you.

Fellwar Stone

{T}: Add one mana of any color that a land an opponent controls could produce.

Vault of Champions

This land enters tapped unless you have two or more opponents.
{T}: Add {W} or {B}.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Expedition Map

{2}, {T}, Sacrifice this artifact: Search your library for a land card, reveal it, put it into your hand, then shuffle.

Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

Fell Mire

As this land enters, you may pay 3 life. If you don't, it enters tapped.
{T}: Add {B}.

Fell the Profane

Fell the Profane // Fell Mire

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: This creature gets +1/+1 until end of turn.