Shadow of Mortality

If your life total is less than your starting life total, this spell costs {X} less to cast, where X is the difference.

Pain's Reward

Each player may bid life. You start the bidding with a bid of any number. In turn order, each player may top the high bid. The bidding ends if the high bid stands. The high bidder loses life equal to the high bid and draws four cards.

Cabal Stronghold

{T}: Add {C}.
{3}, {T}: Add {B} for each basic Swamp you control.

Griselbrand

Flying, lifelink
Pay 7 life: Draw seven cards.

Mind Stone

{T}: Add {C}.
{1}, {T}, Sacrifice Mind Stone: Draw a card.

Withering Boon

As an additional cost to cast this spell, pay 3 life.
Counter target creature spell.

Treacherous Blessing

When Treacherous Blessing enters the battlefield, draw three cards.
Whenever you cast a spell, you lose 1 life.
When Treacherous Blessing becomes the target of a spell or ability, sacrifice it.

Vilis, Broker of Blood

Flying
{B}, Pay 2 life: Target creature gets -1/-1 until end of turn.
Whenever you lose life, draw that many cards. (Damage causes loss of life.)

Tomb Fortress

Tomb Fortress enters the battlefield tapped.
{T}: Add {B}.
{2}{B}{B}{B}, {T}, Exile Tomb Fortress: Mill four cards, then return a creature card from your graveyard to the battlefield. Activate only as a sorcery.

Ebon Drake

Flying
Whenever a player casts a spell, you lose 1 life.

Leechridden Swamp

({T}: Add {B}.)
Leechridden Swamp enters the battlefield tapped.
{B}, {T}: Each opponent loses 1 life. Activate only if you control two or more black permanents.

Vampire Scrivener

Flying
Whenever you gain life during your turn, put a +1/+1 counter on Vampire Scrivener.
Whenever you lose life during your turn, put a +1/+1 counter on Vampire Scrivener.

Carnophage

At the beginning of your upkeep, tap Carnophage unless you pay 1 life.

Toxic Deluge

As an additional cost to cast this spell, pay X life.
All creatures get -X/-X until end of turn.

Imp's Mischief

Change the target of target spell with a single target. You lose life equal to that spell's mana value.

Pact Weapon

As long as Pact Weapon is attached to a creature, you don't lose the game for having 0 or less life.
Whenever equipped creature attacks, draw a card and reveal it. The creature gets +X/+X until end of turn and you lose X life, where X is that card's mana value.
Equip—Discard a card.

Doom Whisperer

Flying, trample
Pay 2 life: Surveil 2. (Look at the top two cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Curse of Fool's Wisdom

Enchant player
Whenever enchanted player draws a card, they lose 2 life and you gain 2 life.
Madness {3}{B} (If you discard this card, discard it into exile. When you do, cast it for its madness cost or put it into your graveyard.)

Gallowbraid

Trample
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Sol Ring

Skirge Familiar

Wound Reflection

At the beginning of each end step, each opponent loses life equal to the life they lost this turn. (Damage causes loss of life.)

Profane Transfusion

Two target players exchange life totals. You create an X/X colorless Horror artifact creature token, where X is the difference between those players' life totals.

Cabal Pit

{T}: Add {B}. Cabal Pit deals 1 damage to you.
Threshold — {B}, {T}, Sacrifice Cabal Pit: Target creature gets -2/-2 until end of turn. Activate only if seven or more cards are in your graveyard.

Reckless Spite

Destroy two target nonblack creatures. You lose 5 life.

Bubbling Muck

Until end of turn, whenever a player taps a Swamp for mana, that player adds an additional {B}.

Dregs of Sorrow

Destroy X target nonblack creatures. Draw X cards.

Death's Shadow

Death's Shadow gets -X/-X, where X is your life total.

Magus of the Mirror

{T}, Sacrifice Magus of the Mirror: Exchange life totals with target opponent. Activate only during your upkeep.

Marshland Bloodcaster

Flying
{1}{B}, {T}: Rather than pay the mana cost of the next spell you cast this turn, you may pay life equal to that spell's mana value.

Wretched Anurid

Whenever another creature enters the battlefield, you lose 1 life.

Dismember

({B/P} can be paid with either {B} or 2 life.)
Target creature gets -5/-5 until end of turn.

Mortarion, Daemon Primarch

Flying
Primarch of the Death Guard — At the beginning of your end step, you may pay {X}. If you do, create X 2/2 black Astartes Warrior creature tokens with menace. X can't be greater than the amount of life you lost this turn.

K'rrik, Son of Yawgmoth

({B/P} can be paid with either {B} or 2 life.)
Lifelink
For each {B} in a cost, you may pay 2 life rather than pay that mana.
Whenever you cast a black spell, put a +1/+1 counter on K'rrik, Son of Yawgmoth.

Wicked Pact

Cruel Bargain

Draw four cards. You lose half your life, rounded up.

Zhentarim Bandit

Whenever Zhentarim Bandit attacks, you may pay 1 life. If you do, create a Treasure token. (It's an artifact with "{T}, Sacrifice this artifact: Add one mana of any color.")

Deadly Tempest

Destroy all creatures. Each player loses life equal to the number of creatures they controlled that were destroyed this way.

Platinum Angel

Flying
You can't lose the game and your opponents can't win the game.

Morinfen

Flying
Cumulative upkeep—Pay 1 life. (At the beginning of your upkeep, put an age counter on this permanent, then sacrifice it unless you pay its upkeep cost for each age counter on it.)

Carnival of Souls

Whenever a creature enters the battlefield, you lose 1 life and add {B}.

Lich

As Lich enters the battlefield, you lose life equal to your life total.
You don't lose the game for having 0 or less life.
If you would gain life, draw that many cards instead.
Whenever you're dealt damage, sacrifice that many nontoken permanents. If you can't, you lose the game.
When Lich is put into a graveyard from the battlefield, you lose the game.

Caustic Bronco

Whenever Caustic Bronco attacks, reveal the top card of your library and put it into your hand. You lose life equal to that card's mana value if Caustic Bronco isn't saddled. Otherwise, each opponent loses that much life.
Saddle 3 (Tap any number of other creatures you control with total power 3 or more: This Mount becomes saddled until end of turn. Saddle only as a sorcery.)

Font of Agonies

Whenever you pay life, put that many blood counters on Font of Agonies.
{1}{B}, Remove four blood counters from Font of Agonies: Destroy target creature.

Cabal Coffers

{2}, {T}: Add {B} for each Swamp you control.

Seizan, Perverter of Truth

At the beginning of each player's upkeep, that player loses 2 life and draws two cards.

Hex Parasite

{X}{B/P}: Remove up to X counters from target permanent. For each counter removed this way, Hex Parasite gets +1/+0 until end of turn. ({B/P} can be paid with either {B} or 2 life.)

Mischievous Poltergeist

Flying
Pay 1 life: Regenerate Mischievous Poltergeist.

Bojuka Bog

Bojuka Bog enters the battlefield tapped.
When Bojuka Bog enters the battlefield, exile target player's graveyard.
{T}: Add {B}.

The Golden Throne

Arcane Life-support — If you would lose the game, instead exile The Golden Throne and your life total becomes 1.
A Thousand Souls Die Every Day — {T}, Sacrifice a creature: Add three mana in any combination of colors.

Sangrophage

At the beginning of your upkeep, tap Sangrophage unless you pay 2 life.

Death Wish

You may put a card you own from outside the game into your hand. You lose half your life, rounded up. Exile Death Wish.

Swamp

Damnable Pact

Target player draws X cards and loses X life.

Blood Celebrant

{B}, Pay 1 life: Add one mana of any color.

Devour in Shadow

Destroy target creature. It can't be regenerated. You lose life equal to that creature's toughness.

Repay in Kind

Each player's life total becomes the lowest life total among all players.

Ad Nauseam

Reveal the top card of your library and put that card into your hand. You lose life equal to its mana value. You may repeat this process any number of times.

Curse of Vengeance

Enchant player
Whenever enchanted player casts a spell, put a spite counter on Curse of Vengeance.
When enchanted player loses the game, you gain X life and draw X cards, where X is the number of spite counters on Curse of Vengeance.

Soul Conduit

{6}, {T}: Two target players exchange life totals.

Cut of the Profits

Casualty 3 (As you cast this spell, you may sacrifice a creature with power 3 or greater. When you do, copy this spell.)
You draw X cards and you lose X life.

Extraplanar Lens

Imprint — When Extraplanar Lens enters the battlefield, you may exile target land you control.
Whenever a land with the same name as the exiled card is tapped for mana, its controller adds one mana of any type that land produced.

Peer into the Abyss

Target player draws cards equal to half the number of cards in their library and loses half their life. Round up each time.

Stinging Study

You draw X cards and you lose X life, where X is the mana value of a commander you own on the battlefield or in the command zone.

Mirror Universe

{T}, Sacrifice Mirror Universe: Exchange life totals with target opponent. Activate only during your upkeep.

Defiler of Flesh

Menace
As an additional cost to cast black permanent spells, you may pay 2 life. Those spells cost {B} less to cast if you paid life this way. This effect reduces only the amount of black mana you pay.
Whenever you cast a black permanent spell, target creature you control gets +1/+1 and gains menace until end of turn.

Slaughter Pact

Destroy target nonblack creature.
At the beginning of your next upkeep, pay {2}{B}. If you don't, you lose the game.

Stunning Reversal

The next time you would lose the game this turn, instead draw seven cards and your life total becomes 1.
Exile Stunning Reversal.

Grim Tutor

Search your library for a card, put that card into your hand, then shuffle. You lose 3 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Vendetta

Destroy target nonblack creature. It can't be regenerated. You lose life equal to that creature's toughness.

Wall of Blood

Defender (This creature can't attack.)
Pay 1 life: Wall of Blood gets +1/+1 until end of turn.

Infernal Contract

Nefarious Lich

If damage would be dealt to you, exile that many cards from your graveyard instead. If you can't, you lose the game.
If you would gain life, draw that many cards instead.
When Nefarious Lich leaves the battlefield, you lose the game.