Go for the Throat

Brotherhood Headquarters

{T}: Add {C}.
{T}: Add one mana of any color. Spend this mana only to cast an Assassin spell or a spell that has freerunning, or to activate an ability of an Assassin source.

Headsplitter

When Headsplitter enters, create a 1/1 black Assassin creature token with menace, then attach Headsplitter to it.
Equipped creature gets +1/+0.
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Brotherhood Spy

At the beginning of combat on your turn, if you control a legendary Assassin, Brotherhood Spy gets +1/+0 until end of turn and can't be blocked this turn.

Brotherhood Regalia

Equipped creature has ward {2}, is an Assassin in addition to its other types, and can't be blocked.
Equip legendary creature {1}
Equip {3} ({3}: Attach to target creature you control. Equip only as a sorcery.)

Mary Read and Anne Bonny

Haste
{T}: Draw a card, then discard a card.
Whenever you discard an Island, Pirate, or Vehicle card, create a tapped Treasure token.

Jackdaw

Whenever Jackdaw deals combat damage to a player, you may discard your hand. If you do, draw a card for each artifact you control.
Crew 3

Petty Larceny

Freerunning {1}{B} (You may cast this spell for its freerunning cost if you dealt combat damage to a player this turn with an Assassin or commander.)
Look at the top two cards of target opponent's library and exile those cards face down. You may play those cards for as long as they remain exiled, and mana of any type can be spent to cast them. Create a Treasure token.

Adrestia

Islandwalk (This creature can't be blocked as long as defending player controls an Island.)
Whenever Adrestia attacks, if an Assassin crewed it this turn, draw a card. Adrestia becomes an Assassin in addition to its other types until end of turn.
Crew 1

Auditore Ambush

Choose one or both —
• Return target creature to its owner's hand.
• Target player searches their library and/or graveyard for a card named Ezio, Blade of Vengeance, reveals it, and puts it into their hand. If they search their library this way, they shuffle.

Tranquilize

Tap target creature an opponent controls and put three stun counters on it. (If a permanent with a stun counter would become untapped, remove one from it instead.)

Assassin Den

Defender (This creature can't attack.)
{3}{U}: Put a +1/+1 counter on target creature you control. It can't be blocked this turn. Activate only as a sorcery.

Desynchronization

Return each nonland permanent that's not historic to its owner's hand. (Artifacts, legendaries, and Sagas are historic.)

Rooftop Bypass

Whenever one or more nontoken creatures you control deal combat damage to a player, create a 1/1 black Assassin creature token with menace. (It can't be blocked except by two or more creatures.)

Black Market Connections

At the beginning of your first main phase, choose one or more —
• Sell Contraband — Create a Treasure token. You lose 1 life.
• Buy Information — Draw a card. You lose 2 life.
• Hire a Mercenary — Create a 3/2 colorless Shapeshifter creature token with changeling. You lose 3 life. (It has every creature type.)

Escape Detection

Freerunning—Return a blue creature you control to its owner's hand. (You may cast this spell for its freerunning cost if you dealt combat damage to a player this turn with an Assassin or commander.)
Return target creature to its owner's hand.
Draw a card.

Adéwalé, Breaker of Chains

When Adéwalé enters, reveal the top six cards of your library. Put an Assassin, Pirate, or Vehicle card from among them into your hand and the rest on the bottom of your library in a random order.
Whenever a Vehicle you control deals combat damage to a player, you may return Adéwalé from your graveyard to your hand.

Basim Ibn Ishaq

Whenever you cast a historic spell, draw a card. Basim Ibn Ishaq can't be blocked this turn. This ability triggers only once each turn. (Artifacts, legendaries, and Sagas are historic.)
Whenever Basim Ibn Ishaq deals combat damage to a player, put a +1/+1 counter on it.

Smoke Bomb

Flash
All creatures have shroud. (They can't be the targets of spells or abilities.)
At the beginning of your upkeep, sacrifice Smoke Bomb. When you do, target creature you control can't be blocked this turn.

Apple of Eden, Isu Relic

{T}, Pay 4 life, Sacrifice Apple of Eden: Look at target opponent's hand and exile those cards face down. You may play those cards this turn, and mana of any type can be spent to cast them. Until end of turn, whenever you play a land or cast a spell this way, its owner draws a card. At the beginning of the next end step, return the exiled cards to their owner's hand. Activate only as a sorcery.

Chain Assassination

Freerunning {1}{B} (You may cast this spell for its freerunning cost if you dealt combat damage to a player this turn with an Assassin or commander.)
Destroy target creature. If another creature died this turn, draw a card.

Achilles Davenport

Freerunning {U}{B} (You may cast this spell for its freerunning cost if you dealt combat damage to a player this turn with an Assassin or commander.)
Menace (This creature can't be blocked except by two or more creatures.)
Other Assassins you control get +1/+1.

Ballad of the Black Flag

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after IV.)
I, II, III — Mill three cards. You may put a historic card from among them into your hand. (Artifacts, legendaries, and Sagas are historic.)
IV — Historic spells you cast this turn cost {2} less to cast.

Submerged Boneyard

Submerged Boneyard enters tapped.
{T}: Add {U} or {B}.

Brotherhood Ambushers

Freerunning {3}{B} (You may cast this spell for its freerunning cost if you dealt combat damage to a player this turn with an Assassin or commander.)

Hidden Blade

Flash
When Hidden Blade enters, attach it to target creature you control. If that creature is an Assassin, it gains deathtouch until end of turn.
Equipped creature gets +1/+0 and has first strike.
Equip {2}

Staff of Eden, Vault's Key

When Staff of Eden, Vault's Key enters, put target legendary permanent card not named Staff of Eden, Vault's Key from a graveyard onto the battlefield under your control.
{T}: Draw a card for each permanent you control but don't own.

Cathartic Reunion

As an additional cost to cast this spell, discard two cards.
Draw three cards.

Hidden Footblade

Flash
When Hidden Footblade enters, attach it to target creature you control. That creature gains first strike until end of turn.
Equipped creature gets +1/+0 and has haste.
Equip {2} ({2}: Attach to target creature you control. Equip only as a sorcery.)

Assassin Initiate

{1}: Assassin Initiate gains your choice of flying, deathtouch, or lifelink until end of turn.

Abstergo Entertainment

{T}: Add {C}.
{1}, {T}: Add one mana of any color.
{3}, {T}, Exile Abstergo Entertainment: Return up to one target historic card from your graveyard to your hand, then exile all graveyards. (Artifacts, legendaries, and Sagas are historic.)

Hired Blade

Flash (You may cast this spell any time you could cast an instant.)

Excalibur, Sword of Eden

This spell costs {X} less to cast, where X is the total mana value of historic permanents you control. (Artifacts, legendaries, and Sagas are historic.)
Equipped creature gets +10/+0 and has vigilance.
Equip legendary creature {2}

Cover of Darkness

As Cover of Darkness enters, choose a creature type.
Creatures of the chosen type have fear. (They can't be blocked except by artifact creatures and/or black creatures.)

Fiery Islet

{T}, Pay 1 life: Add {U} or {R}.
{1}, {T}, Sacrifice Fiery Islet: Draw a card.

Crystal Skull, Isu Spyglass

You may look at the top card of your library any time.
You may play historic lands and cast historic spells from the top of your library. (Artifacts, legendaries, and Sagas are historic.)
{T}: Add {U}.

Ezio, Blade of Vengeance

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Whenever an Assassin you control deals combat damage to a player, draw a card.

Shao Jun

Leap Strike — During your turn, Shao Jun has flying and first strike.
Rope Dart — Tap two untapped artifacts you control: Shao Jun deals 1 damage to each opponent.

Lydia Frye

Lydia Frye can't be blocked by creatures with power 3 or greater.
At the beginning of your end step, surveil X, where X is the number of tapped Assassins you control. (Look at the top X cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)

Eagle Vision

Freerunning {1}{U} (You may cast this spell for its freerunning cost if you dealt combat damage to a player this turn with an Assassin or commander.)
Draw three cards.

Desmond Miles

Menace
Desmond Miles gets +1/+0 for each other Assassin you control and each Assassin card in your graveyard.
Whenever Desmond Miles deals combat damage to a player, surveil X, where X is the amount of damage it dealt to that player.

Murder

Edward Kenway

At the beginning of your end step, create a Treasure token for each tapped Assassin, Pirate, and/or Vehicle you control.
Whenever a Vehicle you control deals combat damage to a player, look at the top card of that player's library, then exile it face down. You may play that card for as long as it remains exiled.