Fumigate

Destroy all creatures. You gain 1 life for each creature destroyed this way.

Adamant Will

Target creature gets +2/+2 and gains indestructible until end of turn. (Damage and effects that say "destroy" don't destroy it.)

Auramancer

When Auramancer enters, you may return target enchantment card from your graveyard to your hand.

Angelic Skirmisher

Flying
At the beginning of each combat, choose first strike, vigilance, or lifelink. Creatures you control gain that ability until end of turn.

Vault 75: Middle School

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Exile all creatures with power 4 or greater.
II, III — Put a +1/+1 counter on each creature you control.

Vitality Hunter

Lifelink
{X}{W}{W}: Monstrosity X. (If this creature isn't monstrous, put X +1/+1 counters on it and it becomes monstrous.)
When Vitality Hunter becomes monstrous, put a lifelink counter on each of up to X target creatures.

Aerial Responder

Ajani Steadfast

+1: Until end of turn, up to one target creature gets +1/+1 and gains first strike, vigilance, and lifelink.
−2: Put a +1/+1 counter on each creature you control and a loyalty counter on each other planeswalker you control.
−7: You get an emblem with "If a source would deal damage to you or a planeswalker you control, prevent all but 1 of that damage."

Emeria Shepherd

Flying
Landfall — Whenever a land you control enters, you may return target nonland permanent card from your graveyard to your hand. If that land is a Plains, you may return that nonland permanent card to the battlefield instead.

Heliod's Intervention

Choose one —
• Destroy X target artifacts and/or enchantments.
• Target player gains twice X life.

Sunblast Angel

Flying
When Sunblast Angel enters, destroy all tapped creatures.

Brave the Sands

Creatures you control have vigilance.
Each creature you control can block an additional creature each combat.

Terramorphic Expanse

{T}, Sacrifice Terramorphic Expanse: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Austere Command

Choose two —
• Destroy all artifacts.
• Destroy all enchantments.
• Destroy all creatures with mana value 3 or less.
• Destroy all creatures with mana value 4 or greater.

Angelic Arbiter

Flying
Each opponent who cast a spell this turn can't attack with creatures.
Each opponent who attacked with a creature this turn can't cast spells.

Archangel of Tithes

Flying
As long as Archangel of Tithes is untapped, creatures can't attack you or planeswalkers you control unless their controller pays {1} for each of those creatures.
As long as Archangel of Tithes is attacking, creatures can't block unless their controller pays {1} for each of those creatures.

Plains

Planar Outburst

Destroy all nonland creatures.
Awaken 4—{5}{W}{W}{W} (If you cast this spell for {5}{W}{W}{W}, also put four +1/+1 counters on target land you control and it becomes a 0/0 Elemental creature with haste. It's still a land.)

Windbrisk Heights

Hideaway 4 (When this land enters, look at the top four cards of your library, exile one face down, then put the rest on the bottom in a random order.)
Windbrisk Heights enters tapped.
{T}: Add {W}.
{W}, {T}: You may play the exiled card without paying its mana cost if you attacked with three or more creatures this turn.

Basilisk Collar

Equipped creature has deathtouch and lifelink.
Equip {2}

Akroma, Angel of Wrath

Flying, first strike, vigilance, trample, haste, protection from black and from red

Linvala, the Preserver

Flying
When Linvala, the Preserver enters, if an opponent has more life than you, you gain 5 life.
When Linvala enters, if an opponent controls more creatures than you, create a 3/3 white Angel creature token with flying.

Bruna, the Fading Light

When you cast this spell, you may return target Angel or Human creature card from your graveyard to the battlefield.
Flying, vigilance
(Melds with Gisela, the Broken Blade.)

Open the Armory

Search your library for an Aura or Equipment card, reveal it, put it into your hand, then shuffle.

The Battle of Bywater

Destroy all creatures with power 3 or greater. Then create a Food token for each creature you control. (It's an artifact with "{2}, {T}, Sacrifice this artifact: You gain 3 life.")

To Arms!

Untap all creatures you control.
Draw a card.

Talisman of Hierarchy

{T}: Add {C}.
{T}: Add {W} or {B}. Talisman of Hierarchy deals 1 damage to you.

Evolving Wilds

{T}, Sacrifice Evolving Wilds: Search your library for a basic land card, put it onto the battlefield tapped, then shuffle.

Congregate

Target player gains 2 life for each creature on the battlefield.

Cleansing Nova

Choose one —
• Destroy all creatures.
• Destroy all artifacts and enchantments.

End Hostilities

Destroy all creatures and all permanents attached to creatures.

Dawn of Hope

Whenever you gain life, you may pay {2}. If you do, draw a card.
{3}{W}: Create a 1/1 white Soldier creature token with lifelink.

Hold the Line

Blocking creatures get +7/+7 until end of turn.

Soul of New Phyrexia

Trample
{5}: Permanents you control gain indestructible until end of turn.
{5}, Exile Soul of New Phyrexia from your graveyard: Permanents you control gain indestructible until end of turn.

Cataclysmic Gearhulk

Vigilance
When Cataclysmic Gearhulk enters, each player chooses an artifact, a creature, an enchantment, and a planeswalker from among the nonland permanents they control, then sacrifices the rest.

Vedalken Orrery

You may cast spells as though they had flash.

Riot Control

You gain 1 life for each creature your opponents control. Prevent all damage that would be dealt to you this turn.

Swords to Plowshares

Exile target creature. Its controller gains life equal to its power.

Commander's Plate

Equipped creature gets +3/+3 and has protection from each color that's not in your commander's color identity.
Equip commander {3}
Equip {5}

Land Tax

At the beginning of your upkeep, if an opponent controls more lands than you, you may search your library for up to three basic land cards, reveal them, put them into your hand, then shuffle.

Myriad Landscape

Myriad Landscape enters tapped.
{T}: Add {C}.
{2}, {T}, Sacrifice Myriad Landscape: Search your library for up to two basic land cards that share a land type, put them onto the battlefield tapped, then shuffle.

Sunscorch Regent

Flying
Whenever an opponent casts a spell, put a +1/+1 counter on Sunscorch Regent and you gain 1 life.

Spectra Ward

Enchant creature
Enchanted creature gets +2/+2 and has protection from each color. This effect doesn't remove Auras. (It can't be blocked, targeted, or dealt damage by anything that's white, blue, black, red, or green.)

Mangara of Corondor

{T}: Exile Mangara of Corondor and target permanent.

Sword of Once and Future

Equipped creature gets +2/+2 and has protection from blue and from black.
Whenever equipped creature deals combat damage to a player, surveil 2. Then you may cast an instant or sorcery spell with mana value 2 or less from your graveyard without paying its mana cost. If that spell would be put into your graveyard, exile it instead.
Equip {2}

Return to Dust

Exile target artifact or enchantment. If you cast this spell during your main phase, you may exile up to one other target artifact or enchantment.

The Core

(Transforms from Matzalantli.)
Fathomless descent — {T}: Add X mana of any one color, where X is the number of permanent cards in your graveyard.

Matzalantli, the Great Door

{T}: Draw a card, then discard a card.
{4}, {T}: Transform Matzalantli, the Great Door. Activate only if there are four or more permanent types among cards in your graveyard. (Artifact, battle, creature, enchantment, land, and planeswalker are permanent types.)

Matzalantli, the Great Door // The Core

Get Lost

Destroy target creature, enchantment, or planeswalker. Its controller creates two Map tokens. (They're artifacts with "{1}, {T}, Sacrifice this artifact: Target creature you control explores. Activate only as a sorcery.")

Windborn Muse

Flying
Creatures can't attack you unless their controller pays {2} for each creature they control that's attacking you.

Sol Ring

Spirit Link

Enchant creature (Target a creature as you cast this. This card enters attached to that creature.)
Whenever enchanted creature deals damage, you gain that much life.

Family Reunion

Choose one —
• Creatures you control get +1/+1 until end of turn.
• Creatures you control gain hexproof until end of turn. (They can't be the targets of spells or abilities your opponents control.)

Ash Barrens

{T}: Add {C}.
Basic landcycling {1} ({1}, Discard this card: Search your library for a basic land card, reveal it, put it into your hand, then shuffle.)

Holy Day

Prevent all combat damage that would be dealt this turn.

Gwaihir, Greatest of the Eagles

Flying
Whenever Gwaihir attacks, target attacking creature gains flying until end of turn.
At the beginning of each end step, if you gained 3 or more life this turn, create a 3/3 white Bird creature token with flying and "Whenever this creature attacks, target attacking creature gains flying until end of turn."

Subjugator Angel

Flying
When Subjugator Angel enters, tap all creatures your opponents control.

Aegis Angel

Flying (This creature can't be blocked except by creatures with flying or reach.)
When Aegis Angel enters, another target permanent gains indestructible for as long as you control Aegis Angel. (Effects that say "destroy" don't destroy it. A creature with indestructible can't be destroyed by damage.)

Obelisk of Urd

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
As Obelisk of Urd enters, choose a creature type.
Creatures you control of the chosen type get +2/+2.

Hour of Reckoning

Convoke (Your creatures can help cast this spell. Each creature you tap while casting this spell pays for {1} or one mana of that creature's color.)
Destroy all nontoken creatures.

Path to Exile

Exile target creature. Its controller may search their library for a basic land card, put that card onto the battlefield tapped, then shuffle.

Akroma, Vision of Ixidor

Flying, first strike, vigilance, trample
At the beginning of each combat, until end of turn, each other creature you control gets +1/+1 if it has flying, +1/+1 if it has first strike, and so on for double strike, deathtouch, haste, hexproof, indestructible, lifelink, menace, protection, reach, trample, vigilance, and partner.
Partner

Arcane Signet

{T}: Add one mana of any color in your commander's color identity.

Odric, Lunarch Marshal

At the beginning of each combat, creatures you control gain first strike until end of turn if a creature you control has first strike. The same is true for flying, deathtouch, double strike, haste, hexproof, indestructible, lifelink, menace, reach, skulk, trample, and vigilance.

Command Tower

Exquisite Archangel

Flying
If you would lose the game, instead exile Exquisite Archangel and your life total becomes equal to your starting life total.

Gisela, the Broken Blade

Flying, first strike, lifelink
At the beginning of your end step, if you both own and control Gisela, the Broken Blade and a creature named Bruna, the Fading Light, exile them, then meld them into Brisela, Voice of Nightmares.

Maze of Ith

{T}: Untap target attacking creature. Prevent all combat damage that would be dealt to and dealt by that creature this turn.

Improvised Armor

Enchant creature
Enchanted creature gets +2/+5.
Cycling {3} ({3}, Discard this card: Draw a card.)

Shatter the Sky

Each player who controls a creature with power 4 or greater draws a card. Then destroy all creatures.